Zoletil 100 1 bottle + 1 bottle of solvent in the package

"Sold by prescription of a veterinarian"

Compound:

The drug in the form of a lyophilized powder for injection of white or light yellow color, complete with a solvent (water for injection), is available in glass vials sealed with chlorobutanol stoppers and rolled up with aluminum caps.

Each vial contains as an active substance: 125 mg of tiletamine hydrochloride and 125 mg of zolazepam hydrochloride Zoletil 50, or 250 mg of tiletamine hydrochloride and 250 mg of zolazepam hydrochloride Zoletil 100. Excipients - sodium sulfate and lactose.

Pharmacological properties:

Tiletamine is a general anesthetic of dissociative action, causing a pronounced analgesic effect, but insufficient muscle relaxation. Tiletamine does not suppress the pharyngeal, laryngeal, cough reflexes, does not depress the respiratory system.

Zolazepam inhibits the subcortical areas of the brain, causing anxiolytic and sedative effects, and relaxes the striated muscles. Zolazepam enhances the anesthetic effect of tiletamine. It also prevents cramps caused by tiletamine, improves muscle relaxation and speeds up recovery from anesthesia.

The time of onset of anesthesia after intramuscular injection is individual, therefore, after the injection of the drug, careful monitoring of the animal should be established.

In cats, the onset of action of the drug after intramuscular administration is noted after 1-7 minutes. The duration of anesthesia depends on the dose, but the maximum effect is usually observed after 20-60 minutes. The recovery period after anesthesia varies from 1 to 5.5 hours.

In dogs, the onset of action of the drug after intramuscular administration is noted on average within 7.5 minutes. The average duration of anesthesia is about 30 minutes, the recovery period is up to 4 hours.

In case of an overdose, as well as in very young and old animals, the recovery period is longer. The active ingredients of Zoletil are metabolized in the liver and excreted in the urine.

Indications for use:

General anesthesia for diagnostic and surgical procedures in cats and dogs.

Dose and method of application:

24 hours before anesthesia, the anti-parasitic collar should be removed from the animal and a 12-hour starvation diet should be maintained.

15 minutes before the administration of the drug, it is recommended to administer atropine sulfate subcutaneously at a dose of 0.1 mg/kg of animal weight for dogs and 0.05 mg/kg of animal weight for cats.

Dilute the contents of the powder vial with the supplied solvent. With intramuscular injection, the loss of rectifying reflexes occurs after 3-6 minutes, with intravenous administration - after 1 minute.

Intramuscular administration:

Dogs: clinical examination - 7-10mg/kg; short-term general anesthesia

with minor surgical interventions - 10-15 mg / kg; long-term general anesthesia for extensive and painful surgical interventions - 15-25 mg / kg.

Cats: clinical examination - 10 mg / kg; long-term general anesthesia for extensive and painful surgical interventions - 15 mg / kg.

Intravenous administration:

Dogs: clinical examination, 5mg/kg; short-term general anesthesia

for minor surgical interventions - 7.5 mg / kg; long-term general anesthesia for extensive and painful surgical interventions - 10 mg / kg.

Cats: clinical examination - 5 mg / kg; prolonged general anesthesia for extensive and painful surgical interventions - 7.5 mg / kg.

If necessary, Zoletil can be re-introduced at a dose not exceeding 1/3-1/2 of the original dose.

Zoletil does not have a cumulative effect and can be injected repeatedly, in doses not exceeding 1/3-1/2 of the initial dose. In this case, the total dose of the drug should not exceed the safety threshold: 30 mg / kg for dogs and 72 mg / kg for cats; in both animal species, the minimum lethal dose is 100 mg/kg. The duration of anesthesia is from 20 to 60 minutes.

Recovery from anesthesia: The analgesic effect of Zoletil is longer than that caused by surgical anesthesia. Recovery from anesthesia is gradual (2-6 hours) and calm, provided there is no noise and bright light. In cases of overdose, as well as in very young and old animals, the recovery period is longer.

Animal species:

dogs, cats.

Special instructions:

The simultaneous use of Zoletil and chloramphenicol prolongs anesthesia in cats by an average of 30 minutes.

Simultaneous use of Zoletil with phenothiazine (acepromazine) causes respiratory and cardiac depression. With the simultaneous use of Zoletil with barbiturates or inhalation anesthetics, the dose of the latter should be reduced.

Storage conditions:

List B. 2 years from the date of manufacture at a temperature of +5 to +20°C. The solution is stored for 8 days in a dark place at a temperature of +4°C, at room temperature - 24 hours.

Manufacturer:

Virbas, France.