Pharmacological properties

Pharmacodynamics. oxymetazoline is sympathomimetic amine of direct action. it affects α-adrenoceptors of blood vessels of a mucous membrane of a nose, causing vasoconstriction and eliminating hypostasis of a mucous membrane. oxymetazoline narrows vessels in the place of application, reduces a rhinedema and the upper airways. elimination of a rhinedema promotes restoration of aeration of adnexal bosoms, a tympanic cavity that prevents development of bacterial complications.

antiviral, anti-inflammatory, immunomodulatory and antioxidant action. Thanks to this combined mechanism of action faster and effective elimination of the rhinedema caused by sharp rhinitis is proved. Duration of effect of medicine — up to 12 h

Pharmacokinetics. At topical nasal administration in therapeutic concentration does not irritate a mucous membrane of a nose, does not cause hyperaemia. The t _½ makes about 35 h after use of medicine. 2.1% are allocated with kidneys, about 1.1% — are removed with a stake.

Indication

Acute respiratory diseases which are followed by congestion of a nose. allergic rhinitis. vasomotorial rhinitis. for restoration of a drainage and nasal breath at diseases of adnexal bosoms of a nasal cavity, an eustachitis. for elimination of hypostasis before diagnostic manipulations in the nasal courses.

Use

1 inhalation dose (50 mkl) contains about 25 mkg of oxymetazoline of a hydrochloride.

Adults and children aged from 6 years: on 1 injection in each nasal course 2–3 times a day.

should not use Drug longer than 5-7 days. Doses are higher recommended to apply only under observation of the doctor.

can use Drug repeatedly only in several days.

Contraindication

Hypersensitivity to active ingredient or to any of excipients; atrophic rhinitis; inflammation or injury of a mucous membrane of a nose or skin around nostrils; simultaneous use of inhibitors of Mao and during 2 weeks after the treatment termination by Mao's inhibitors and also use of other medicines promoting increase hell; the increased intraocular pressure, especially closed-angle glaucoma; severe forms of cardiovascular diseases (for example ibs, ag); cardiac asthma; pheochromocytoma; metabolic violations (hyperthyroidism, diabetes, porphyria); patients after transsphenoidal hypophysectomy; the complicated urination at increase in a prostate (prostatauxe).

Side effects

from the immune system: allergic reactions, including rash, itch, Quincke's disease.

from a respiratory system: discomfort in a nose, burning or xeromycteria, dryness and irritation in a mouth and a throat, sneezing, nasal bleeding. After the effect of use of medicine ends, there can be a feeling of strong congestion of a nose (reactive hyperemia). An apnoea at newborns and children of younger age (especially in case of overdose).

from an organ of sight: irritation of eyes, reddening or sensation of discomfort.

from nervous system: a headache, insomnia, uneasiness, drowsiness, concern, a tremor, sedative action, irritability, spasms, hallucinations (especially at children), increased fatigue.

from a cardiovascular system: tachycardia, the strengthened heartbeat, AG.

General violations: reactive hyperemia, headache, nausea, dieback and disorders of vision.

Special instructions

Should avoid prolonged use and overdose of medicine. prolonged use of antiedematous for a nose can lead to weakening of effect of medicine. abuse of this means can cause atrophic rhinitis, a mucosal atrophy of a nose and a reactive hyperemia with medicamentous rhinitis.

After use of medicine needs special health surveillance of patients with chronic rhinitis. Doses are higher recommended it is possible to apply only under observation of the doctor.

If symptoms amplify or improvement is absent within 3 days, it is necessary to see a doctor.

chloride which is a part of medicine can cause a rhinedema, especially on condition of prolonged use. If there is a suspicion on similar reaction (constant congestion of a nose), it is necessary to use the medicament which is not containing preservatives. At impossibility of use of medicine without preservatives it is necessary to consider the possibility of application of other dosage form.

Use during pregnancy and feeding by a breast. During pregnancy and feeding by a breast medicament is used with care. It is not necessary to exceed the recommended doses.

Children. Drug should not be used at children under 6 years.

Ability to influence speed of response at control of vehicles or work with other mechanisms. After prolonged use of medicine in the doses exceeding recommended it is impossible to exclude the general influence on cardiovascular and nervous system. In such cases the ability to steer the vehicle can worsen.

Interaction

not to apply Mao's inhibitors and other medicines with hypertensive action because of risk of increase hell.

Combined use of other vasoconstrictive medicines increases risk of development of side effects.

Knows that this medicine interacts with tricyclic antidepressants that can be shown in increase in risk of development of AG and arrhythmia.

Should be applied with care at patients who apply Bromocriptinum as development of violations from a cardiovascular system is possible.

.

Overdose

After considerable overdose or accidental intake such symptoms can arise: a mydriasis, nausea, vomiting, cyanosis, fervescence, spasms, tachycardia, palpitation, arrhythmia, cardiovascular insufficiency, cardiac arrest, the increased sweating, agitation, spasms, ag, a fluid lungs, respiratory violations, pallor, a miosis, a hyposmia, mental disorders.

besides, oppression of the central nervous system functions can arise that is shown by drowsiness, decrease in body temperature, bradycardia, arterial hypotension, an apnoea and possible development of a coma.

Treatment: gastric lavage, intake of activated carbon, IVL. At decrease in the ABP apply phentolamine. It is not necessary to accept angiotonic means. If necessary anticonvulsant therapy is shown.

Storage conditions

At a temperature not above 25 °C.

Information on medicine for experts of health care.