Pharmacological properties

Vitamin E — oil-soluble vitamin which has significant antioxidant and radio tire-tread effect takes part in biosynthesis of a gem and proteins, proliferation of cells and other major processes of cellular metabolism.

Vitamin E improves consumption by oxygen fabrics. Has angioprotektorny effect, influencing a tone and permeability of vessels, stimulating formation of new capillaries.

Immunomodulatory effect of vitamin E is caused by stimulation of T-cellular and antibody-mediated immunity.

for normal reproductive processes: fertilisations, fetations, formations and functioning of a reproductive system.

At deficiency of vitamin E the hypotonia and dystrophy of skeletal muscles, a myocardium develop, the permeability and fragility of capillaries increase, the degeneration of photoreceptors causing a disorder of vision develops. Decrease in sexual function at men and disturbance of a menstrual cycle, tendency to abortions at women develops.

Deficiency of vitamin E can cause development of hemolytic jaundice in newborns and also a sprue, a steatorrhea.

After absorption in intestines the most part of tocopherol comes to a lymph and blood, is quickly distributed in body tissues with primary accumulation in a liver, muscles, fatty tissue. The highest concentration is defined in adrenal glands, a hypophysis, gonads, a myocardium. The most part of medicament is brought out of an organism with urine, partially — with bile.

Indication

Hypovitaminosis and avitaminosis of vitamin E. in complex antioxidant therapy, in the period of a convalescence after injuries, heavy somatopathies, at physical overworks, unbalanced food.

as a part of complex therapy:

• for prevention of pathology of embryonic development, congenital anomalies (malformations) of a fruit;
• threat of termination of pregnancy;
• disturbances of a menstrual cycle, krauroz of a vulva, climacteric disorders;
• perceptual disorders of hearing;
• atrophic processes in a mucous membrane of airways;
• degenerative and proliferative changes in joints and fibrous tissue of a backbone and large joints; muscle weakness owing to discogenic blockade in diseases of an intervertebral disk, a scleroderma, a lupus erythematosus, a pseudorheumatism, other general diseases of connective tissue;
• a neurasthenia with exhaustion, mainly dystrophies of muscles and an atrophy of muscles, secondary muscle weakness and a myopathy in chronic arthritis;
• vegetative disorders;
• some endocrine disorders;
• some cardiovascular diseases;
• atrophic processes in a mucous membrane of digestive system, disorders of food, a sprue, alimentary anemia, chronic hepatitis;
• some periodontopathies;
• diseases of eyes;
• skin diseases: dermatitis, trophic ulcers, psoriasis, eczema;
• at a plastic induration of a penis, a balanitis, disturbance of a libido, disturbance of functions of gonads at men, disorder of a spermatogenesis and potency at men, infertility (in combination with vitamin A).

Hypervitaminosis of A and D.

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inside after a meal, to select a dose individually, depending on a look, courses of the disease, conditions of the patient. whole should swallow of the capsule, washing down with enough water.

dosing Mode for adults:

• in complex antioxidant therapy: on 0.2-0.4 g 1–2 times a day;
• in pathology of embryonic development, congenital anomalies (malformations) of a fruit: on 0.1 - 0.2 g of 1 times a day in І a pregnancy trimester;
• at threat of termination of pregnancy: on 0.1 g 1–2 times a day for 14 days;
• at disturbances of a menstrual cycle in complex treatment: 0.3 - 0.4 g every other day since 17th day of a cycle (to repeat 5 cycles);
• at disturbances of a menstrual cycle in case of use of medicament prior to hormonal therapy: on 0.1 g 1–2 times a day for 2–3 months;
• in a pseudorheumatism: on 0.1 - 0.3 g daily for several weeks;
• in muscular dystrophies, diseases of the neuromuscular and tendinous and articulate device: on 0.1 g 1–2 times a day for 30–60 days, a repeated course — in 2–3 months;
• at a neurasthenia with exhaustion: to take the medicament in a dose 0.1 g of 1 times a day for 30–60 days;
• at some endocrine disturbances: on 0.3 - 0.5 g/days;
• in some cardiovascular diseases: on 0.1 g/days;
• in alimentary anemia: on 0.3 g/days within 10 days;
• in chronic hepatitis: for a long time on 0.3 g/days;
• in some periodontopathies: on 0.2 - 0.3 g/days;
• in diseases of eyes: on 0.1 - 0.2 g 1–2 times a day for 1–3 weeks in a combination with vitamin A;
• in skin diseases: on 0.1 - 0.2 g 1–2 times a day for 20–40 days;
• at a plastic induration of a penis: on 0.3 - 0.4 g/days within several weeks, then on doctor's orders;
• at disturbances of a spermatogenesis and potency at men: on 0.1 - 0.3 g/days in combination with hormonal therapy for 30 days.

In other cases of a dose and duration of treatment is defined by the doctor.

For adults the single average dose makes 0.1 g, a single highest dose — 0.4 g; the daily average dose makes 0.2 g, the highest daily dose — 1.0 g

Vitamin E in a dose of 0.1 g children can appoint

from 12 years.

Contraindication

Increased individual sensitivity to active ingredient or any components of drug, the expressed cardiosclerosis, an acute myocardial infarction, a thyrotoxicosis, a hypervitaminosis e, children's age up to 12 years.

Usually medicament is transferred by

well, however at prolonged use of high doses within 0.4-0.8 g/days strengthening of a gipotrombinemiya, visual disturbances, dizziness, nausea, development of gastrointestinal bleedings, diarrhea, a stomach ache, increase in a liver, a creatinuria, a digestive disturbance, increased fatigue, the general weakness, a headache are possible. allergic reactions, including skin rash, an itching, a dermahemia and fervescence are possible.

Special instructions

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With care in atherosclerosis, the increased risk of developing a thrombembolia.

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Seldom note a creatinuria, increase in activity of a creatine kinase, increase in concentration of XC, thrombophlebitis, a pulmonary embolism and thrombosis at the patients inclined to it. At a bullous epidermolysis hair of white color can begin to grow in the places struck with an alopecia.

At use of medicament needs to adhere to the mode of dosing and duration of a course of treatment appointed by the doctor for prevention of overdose and developing of a hypervitaminosis of vitamin E.

At long use of high doses of medicament needs to control a blood clotting time.

Use during pregnancy and feeding by a breast. Drug can be used under control of the doctor in the recommended doses during pregnancy or feeding by a breast.

Drug partially gets through a placental barrier; vitamin E comes to a fruit organism where its quantity is 20–30% of concentration of vitamin E in blood plasma of mother.

Vitamin E also gets into breast milk.

Children. Drug is contraindicated to children aged up to 12 years.

Ability to influence speed of response at control of vehicles or other mechanisms. When developing dizziness, mistings sight it is necessary to refrain from control of vehicles or work with other mechanisms.

Interaction

Vitamin E cannot be applied combined with preparations of iron, silver, the means having the alkaline environment (Natrii hydrocarbonas, Trisaminum), anticoagulants of indirect action (Dicumarinum, neodicoumarin).

Vitamin E strengthens action steroid and non-steroidal anti-inflammatory medicaments (sodium diclofenac, an ibuprofen, Prednisolonum); reduces toxic effect of cardiac glycosides (digitoxin, digoxin), vitamins A and D. Prescribing of vitamin E in high doses can cause vitamin A deficiency in an organism.

Vitamin E and its metabolites have antagonistic effect concerning vitamin K.

Vitamin E increases efficiency of antiepileptic medicines at patients with epilepsy.

Colestyraminum, kolestipol, mineral oils reduce vitamin E absorption.

Overdose

Symptoms. at reception of the recommended doses the undesirable reactions are not shown. reception of high doses of vitamin E (0.4-0.8 g/days for a long time) can cause visual disturbances, diarrhea, dizziness, a headache, nausea or spasms in a stomach, very strong fatigue or weakness.

to increase in risk of developing bleedings at patients with deficiency of vitamin K; to disturbance of metabolism of hormones of a thyroid gland and increase in risk of developing of thrombophlebitis and thrombembolia at sensitive patients, to increase in activity of a creatine kinase, concentration of XC, TG in blood plasma, to increase in content of estrogen and androgens in urine.

Treatment. Drug withdrawal, symptomatic therapy.

Storage conditions

In original packing at a temperature not above 25 °C.