Solution "A pyridoxine hydrokhlorid-Zdorovye" is applied to injections at the following indications:

• hypo - and B6 vitamin avitaminosis;
• complex treatment of toxicosis of pregnant women, atherosclerosis, anemias (including sideroblastny), leukopenias, diseases of nervous system (sciaticas, neuritis, neuralgia, parkinsonism, Littl's disease), depressions of involutional age, seboreepodobny and not seborrheal dermatitis, shingles, neurodermatitis, psoriasis, exudative diathesis, at a conclusion from hard drinking and a hangover syndrome;
to appoint
• also in air and sea diseases, Menyer's disease;
• a pyridoxine the hydrochloride warns or reduces toxic effects (especially polyneurites) at treatment by antitubercular drugs;
• treatment of piridoksinzavisimy spasms.

Structure

Active ingredient - pyridoxine (1 ml of solution contains a pyridoxine of a hydrochloride 50 mg).

Excipient - water for injections.

Contraindication

• hypersensitivity to a hydrochloride pyridoxine;
• a peptic ulcer of a stomach and duodenum (in connection with possible increase in acidity of gastric juice);
• a disease of a liver, proceeding with heavy functional insufficiency;
• coronary heart disease.

by

intramusculary, intravenously or subcutaneously in cases when oral administration is impossible. The course of treatment is individual and is defined by type and disease severity. To prepare solution just before use: to part a single dose of medicament in 1-2 ml of water for injections or 0.9% chloride sodium solution.

B6 Hypovitaminosis. To appoint in a daily dose 50-100 mg (1-2 ml) for 1-2 introductions; a course of treatment - 3-4 weeks.

Anemia sideroblastny. To appoint intramusculary in a dose 100 mg (2 ml) 2 times a week. It is reasonable to appoint at the same time folic acid, B12 vitamin, Riboflavinum.

Parkinsonism. To appoint intramusculary in a dose 100 mg (2 ml). A course of treatment - 20-25 injections in 2-3 months to carry out repeated therapy. According to other scheme of treatment to begin 50-100 mg (1-2 ml) with a daily dose, then daily to increase a dose by 50 mg (1 ml) and to bring it to a daily dose of 300-400 mg (6-8 ml) in the form of a single injection within 12-15 days.

Depression of involutional age. To appoint intramusculary in a dose 200 mg (4 ml); a course of treatment - 20-25 injections.

Use of medicaments of group of an isoniazid. To preventively appoint in a daily dose 5-10 mg (0.1-0.2 ml) during all course of treatment an isoniazid.

Overdose of medicaments of group of an isoniazid. On each 1 g of the overdosed medicament to enter 1 g (20 ml) of a pyridoxine with a speed of 0.5 g/minute. At overdose of an isoniazid more than 10 g a pyridoxine to enter in a dose 4 g (80 ml), then intramusculary - on one (20 ml) of a pyridoxine each 30 minutes. The general daily dose - 70-350 mg/kg.

Toxicosis of pregnant women. To appoint in a daily dose 50 mg (1 ml) intramusculary; a course of treatment - 10-20 injections.

Piridoksinzalezhn's

anemia (gland, macrocytic, hypochromia with increase in level, in plasma). Appoint in a dose 50-200 mg (1-4 ml) within 1-2 months. In case of lack of effect to pass to other type of therapy.

Piridoksinzavisimy syndrome, including piridoksinzavisimy spasms. To appoint intravenously (to enter with a speed of 50 mg/min.) or intramusculary in a daily dose of 50-500 mg (1-10 ml); a course of treatment - 3-4 weeks.

Other indications. It is usually appointed in a daily dose of 50-100 mg (1-2 ml) for 1-2 introductions.

For children in B6 hypovitaminosis a dose is appointed by a vra individually at the rate of 1-2 mg/kg of body weight a day; a course of treatment - two weeks. In piridoksinzavisimy spasms to enter in a daily dose 50-100 mg (1-2 ml) intravenously struyno with a speed of 50 mg/minute or intramusculary; the maximum doses for children are not established. At overdose of medicaments of group of an isoniazid on each 1 g of the overdosed medicament to enter 1 g (20 ml) of a pyridoxine. If the dose of an isoniazid is unknown, to enter a pyridoxine at the rate of 70 mg/kg of body weight; the maximum dose - 5 g (100 ml).

Pregnant

Drug to appoint

Feature of use by

Drivers

Drug usually does not affect ability to drive the car or to work with mechanisms, however it is necessary to consider a possibility of development of side reactions from central nervous system.

Overdose

Symptoms: strengthening of side effects; disturbance of exchange of proteins, carbohydrates and lipids; degenerative changes in central nervous system (peripheral neuropathy) and parenchymatous bodies (the disturbances of processes of exchange connected with considerable decrease of the activity of nikotinamidny coenzymes of NAD and NADF and deficiency of niacin). Symptoms of peripheral neuropathy include hyper paresthesia, paresthesia, muscle weakness. Partial baldness, decrease in resilience to infections, decrease of the activity of the anticurtailed system of blood are possible touch neuropathy with the progressing disturbance of gait, feeling of numbness and pricking in legs and hands. At long introduction in high doses B6 hypervitaminosis which is characterized by sharp decrease in protein content in muscle tissue and internals develops. At early stages of a hypervitaminosis of B6 the enanthesis, dizziness, spasms can develop. At medicament withdrawal these signs the return.

Treatment: medicament withdrawal, symptomatic therapy.

Side effects

from a cardiovascular system: tachycardia, pain in heart.

from nervous system: a headache, dizziness, weakness, drowsiness, excitement, a lack of coordination, paresthesias, numbness in extremities, a symptom "stockings and gloves" (feeling of compression in extremities), a loss of consciousness and development of spasms at fast introduction.

from a respiratory system: the complicated breath.

from a digestive tract: nausea, gastralgia, heartburn, increase in gastric secretion.

from a metabolism, metabolism: decrease in level of folic acid.

from the immune system, skin and hypodermic cellulose: reactions of hypersensitivity, including an acute anaphylaxis, urticaria, rash, an itching, a dermahemia, fever, dermatitis, a Quincke's disease, a photosensitization.

Disturbance in the injection site, including hyperaemia, an itching, burning.

Interaction

Cannot mix pyridoxine solution in one syringe with thiamine solution (B1 vitamin), cyanocobalamine solution (B12 vitamin), alkaline solutions, salts of iron and solutions of oxidizers. It is not recommended to mix in one infusional system or in one syringe with such medicines: adrenomimetik, ampicillin sodium salt, Amphotericinum B, ascorbic acid, phytomenadionum, Dipiridamolum, oksiferiskorbon sodium, derivatives of a fenotiazin (Chlorpromazinum), furosemide, etamsylate, Euphyllinum.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 3 years.