Medicine is intended for carrying out hypodermic chipping of adult and mature males of such representatives as dogs, cats, polecats. After holding a procedure, the male is not capable to a reproduction since sixth week and for not less than six months. Implantation is carried out to not dependences on the animal size. It is necessary to remember that the qualified specialist only after full inspection of the pet has to perform this operation.

Advantage:

Perfectly is suitable

• for nurseries.
• Applied to achievement of temporary infertility of males.
• For keeping of heterosexual representatives of a look in one room.
• After chipping the oppression of the hormones which are responsible for reproduction happens.
When validity periods will end with
• If needs to stop influence of an implant, it is deleted surgically.
can act as
• For polecats as treatment of a disease of adrenal glands.

Before use of medicine consult with the veterinarian and study the INSTRUCTION *, given below!!!

Instruction for application

Structure
Nonsteroid contraceptive contains 4.7 mg of deslorelin (acetate) in quality of active ingredient. Excipients: the hydrogenated palm oil, lecithin, waterless acetate natr_yu.
Medicine represents a white or pale yellow cylindrical implant, is entered by the expert of veterinary medicine under skin.
Implant is delivered in previously loaded needles for an implanter. Each needle is packed into tight sterile packing. The box of cardboard contains two sterile individual needles for implantation and also the device (drive), will not sterilize. The drive fastens to a needle by means of the threaded connection.

Pharmacological properties
Pharmacotherapeutic group gonadotrophin-rileasing hormone (LG).
Suprelorin is nonsteroid contraceptive.

Antagonist of GnRH deslorelin works due to suppression of function of a hypophysis, gametes, at application in low, continuous doses. It leads to suppression of ability of experimental animals to synthesize and/or release the follikulostimuliruyushchy hormone (FSG) and the lyuteiniziruyushchy hormone (LH) responsible for maintenance of fertility. Continuous allocation from an implant of low doses of deslorelin reduces functionality of male genitals, a libido and a spermatogenesis. Decrease in level of testosterone in plasma happens in 4-6 weeks after implantation. Short-term there (takes place) increase in testosterone in plasma of blood can be right after implantation. Measurement of concentration of testosterone in plasma showed steady pharmacological effect of constant presence of deslorelin, at least within six months after introduction to medicine. To Bulo it is shown that in plasma the peak deslorelin levels were observed from 7 to 35 days after introduction of an implant. Medicine can be measured in plasma approximately up to 2.5 months after implantation. deslorelin quickly is metabolized.

Indication Apply

• induction of temporary infertility at healthy, mature males of dogs, cats and polecats. Temporary sterilization is irreplaceable when viscous animals it is undesirable time at present (for example, owners of nurseries) or just owners of animals do not want to carry out castration of the pet by a surgical way.
• Introduction of an implant allows to suppress sexual function, approximately for 6 months.
• Besides, Suprelorin is applied to treatment of diseases of adrenal glands (a problem at polecats).

Dose and a method of application
Way of introduction - hypodermic. Similar to the procedure chipping of animals. The recommended dose makes one implant on a dog, irrespective of the size. At introduction of medicine it is necessary to observe measures of an asepsis and antiseptics. If hair long, the small site it is necessary to be obstrigta if it is necessary. Remove a protective cap at the heart of a needle. Attach a needle to an implanter by means of the threaded connection.

Suprelorin can be implanted under a skin on a back between a neck and lumbar area. Avoid introduction of an implant to fat as release of active agent can be excited in area from a low vaskulyarization. Lift the site of skin between shovels. Insert all length of a needle hypodermically. Completely press the piston and slowly extend a needle. Press skin in an installation site while the needle is removed, and support pressure within 30 seconds. Check the syringe and a needle to make sure that the implant did not remain in a needle. Can be possible to probe an implant on the place of introduction.

Repeat the procedure each six months for maintenance of efficiency. Biocompatible implants do not demand removal. However, in case of need to stop treatment, the implant can be removed in the surgical way. It is possible to reveal it by means of ultrasound.

Special preventions: Infertility is reached in 6 weeks after introduction of medicine and not less than 6 months after an injection last. The processed males should be held still far away from a bough within the first six weeks after introduction of an implant. Any pairing if occurs more than in six months after introduction of medicine can lead to pregnancy. If the product is appointed each 6 months, the bough and dogs can be held together. Ability of dogs to generate posterity after their return to the normal level of testosterone in plasma after medicine introduction, were not investigated. As for testosterone level (substitute marker of fertility), during clinical trials more than 80% of dogs after maintaining one or several implants, returned to the normal level of testosterone in plasma (= 0.4 ng/ml) within 12 months.

However, the data confirming full of turnover of clinical effect (reduction of the sizes of testicles, decrease in volume of an ejaculation, decrease in quantity of spermatozoa and decrease in a libido) including fertility after six months, or repeated implantations, are limited. During clinical trials, the majority of dogs of the smaller size (less than 10 kg) supported the low level of testosterone of more than 12 months after implantation. For very big dogs (> 40 kg), data are limited, but duration of suppression of testosterone was comparable with that as in average and large dogs.

Suprelorins Use at dogs weighing less than 10 kg or 40 kg of weight, has to be estimated by the veterinarian.

Overdose was not observed by
Collateral reactions after simultaneous introduction hypodermically up to 10 implants.

Side effects Moderate hypostasis in the place of implantation can be observed by
within 14 days.

In some dogs histologically appeared local reaction with chronic inflammation of connecting fabric and formation of the capsule from collagen in 3 months after introduction. Considerable reduction of the sizes of testicles will be visible during the entire period of treatment. Seldom or never the small egg can rise above an external abdominal ring.

Contraindication inadmissible
use during pregnancy, feedings by a breast.

Special instructions
Interaction with other medicines: it is not known.

Special precautionary measures: Use of a product at teenage age of dogs were not investigated by
. Therefore it is recommended that dogs have to be completely ripened prior to Suprelorins application. Data show that use of medicine allows to lower a libido of a dog, but other changes in behavior (for example, connected with aggression) were investigated.

Special precautionary measures for destruction of veterinary medicines: Any the unused veterinary medicine and waste received from such veterinary medicines have to be utilized according to local requirements.
Means can be reused.

Measure of personal security
Special precautionary measures have to be taken by the persons which are carrying out work with this veterinary medicine.
Beremeny women should not work with medicine.
Special researches to estimate effect of deslorelin at inclusion in time of pregnancy were carried out.
Though contact of skin with a product is hardly possible if it occurs, wash out the struck place at once as analogs of GnRH can be soaked up through skin. Pras
work with Suprelorin, be careful to avoid an accidental independent injection. The animal has to keep as appropriate, and the needle of medicine has to be protected until implantation. In case of an accidental independent injection immediately to see a doctor.

Storage conditions
Store medicine in the closed packing of the producer, in protected from light, the place, inaccessible for children and animals, separately from foodstuff and forages at a temperature from 2 ° up to 8 °C. not of a zamorozhuvata. Not to apply a product if packing is broken by

Use the instruction which is posted on the website for acquaintance with indications and a dosage of medicine. The instruction is provided ​​ in a short form. The full instruction contains in medicine packing.
Packing : 2х4.7 ml
Producer : Virbac, Virbac Corporation, France Species of an animalDogs
Cats
RodentsSpecies of rodentsPolecatsCategory of veterinary medicineHormonal medicinesArea of application of veterinary medicineOther types of diseases
Regulation of sexual activityMedicinesChemotherapeutic medicinesFormSolutions for injections