Pharmacological properties

The complex of three active ingredients provides both antibiotic and antifungal effects, as well as an action to relieve the filling and itching that accompany otitis media, thanks to gentamicin (as a sulfur form), miconazole (as a nitrogen form) and hydrocortisone MPA, respectively.

Hydrocortisone has a powerful anti-inflammatory effect. It inhibits the activity of various tissue-destroying enzymes - proteases and nucleases, matrix metalloproteinases, hyaluronidase, phospholipase, etc., inhibits the synthesis of prostaglandins, kinins, leukotrienes and other mediators of inflammation from arachidonic acid. It also reduces the permeability of tissue barriers and vascular walls, inhibits exudation of fluid and protein into the focus of inflammation, migration of leukocytes to the focus (chemotaxis) and proliferation of connective tissue in the focus, stabilizes cell membranes, inhibits lipid peroxidation, the formation of free radicals in the focus of inflammation, and many other processes that play a role in causing inflammation. Also has a powerful anti-allergic effect.

Gentamicin actively penetrates the bacterial cell membrane, suppresses the protein synthesis of the pathogen. Has a high activity against aerobic gram-negative bacteria: Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Serratia spp., Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp. It is also active against aerobic cocci: Staphylococcus spp. (Including those resistant to penicillin and other antibiotics), some strains of Streptococcus spp. The fungicidal effect of miconazole is associated with a violation of the synthesis of ergosterol, a component of the fungal cell membrane. Miconazole binds to individual links in the ergosterol biosynthesis chain, causing the fungistatic effect of the drug. The products of the disrupted biosynthetic chain are incorporated into the cell membrane of fungi, damaging its integrity.

testimony

Isotic is prescribed for the treatment of otitis externa in dogs caused by mixed infections (bacterial and fungal), including Malassezia pachydermatis, Staphylococcus pseudointermedius.

Doses and method of administration

Pre-clean the pets auricle from sulfur, mechanical impurities and crusts. This can be done with a cotton swab dipped in a little ear cleaner.

Before the first use, press the pump 2 times to fill the cannula with the full dose of the drug. Insert the cannula into the external auditory canal of the damaged ear and add 1 ml of the suspension. The suspension is applied to the ear once a day for 5 days.

Due to the presence of gentamicin Isotic in the composition of the product, it brings relief to the pet in the shortest possible time, eliminating pain and itching, as well as reducing the swelling of the affected area.

SIDE EFFECTS

With proper use and dosage, side effects are usually not observed.

Contraindications

Do not use in dogs with a perforated eardrum. Do not use in dogs with hypersensitivity to active ingredients of the drug.

SPECIAL INSTRUCTIONS

Simultaneous use with potentially ototoxic drugs should be avoided. Use with caution in dogs with impaired liver and kidney function.

STORAGE CONDITIONS

Store in a dry place, protected from direct sunlight, out of reach of children and animals, separately from food and feed at temperatures from 0 to 30 ° C. Shelf life in unopened manufacturers packaging is 24 months from the date of manufacture. The shelf life of an opened package is 10 days after the first use.