Virbac Cortavance 0.584 mg/ml spray (Kortavans) Sprey from an itch for dogs the Dosage form and packing: Preparat is presented in the form of flying mix and does not demand rubbing in, is packed into the plastic white bottles with the twisting cap equipped with the pulevizator of 76 ml in cardboard boxes of Sostav: acting substance: a hydrocortisone atseponat - 0.05842 gr an auxiliary component: propylene glycol methyl air - up to 76 ml. A hydrocortisone ansponat slows down reactions of hypersensitivity, proliferative and exudative processes in connecting fabric, in the inflammation center. Reduces local giperemnyu and a skin hyperthermia. Action is mediated through specific intracellular receptors. Prevents activation of a phospholipase of A2, stimulating formation of its inhibitor — a lipomodulin and owing to direct impact on cellular membranes, breaks synthesis of PG and allocation of a makrofagalny hemotaksichesky factor, inhibits activation of fabric kini. To Umenshayetmigratsy of macrophages and lymphocytes in the inflammation center. Blocks Fc-receptors on a surface of macrophages for IgG and C3 of a component of a complement. Stabilizes membranes of lysosomes, preventing release of lizosomalny enzymes. Suppresses alteration, an ekssudation and proliferation. In high doses slows down development of lymphoid and connecting fabric, the activity of a gialuronidaza oppresses, reduces permeability of capillaries. Brakes products of a collagenase and activates synthesis of inhibitors of proteases. Blocks synthesis and release from sensibilized corpulent cages and basophiles of a histamine and other biologically active agents, suppresses various stages of immunogenesis, without having mitostatichesky effect. Order of application and dosage: Kortavans appoint for symptomatic treatment of the inflammatory and itching dermatosis at dogs. Ne to allow hits of medicine on mucous membranes and in eyes of an animal. Kortavans apply outwardly, aerozolno. Medicine is applied once within 7 days, at the rate of 1.52 mg. a hydrocortisone of the atseponat for 1 cm of skin (that corresponds to two pressing of a head of a bottle, on a surface equivalent on the area of 10 x 10 cm). Sleduyet to consult with the veterinarian in case more long-term treatment is required. Preparat is presented in the form of flying mix and does not demand rubbing in. By-effects and complications at Kortavanss application according to the instruction it is not established. Kortavanss application does not exclude use of medicines of epiotropny and pathogenetic therapy. Medicine use is forbidden to cats. To the pregnant and feeding dogs, and also to puppies more young than 7-month age use the veterinarian according to purpose. It is forbidden to apply medicine on skin ulcers. Method of application and dosage: Preparat spray on the struck surface of skin from distance 10 cm. Medicine is applied within 7 days continuously at the rate of 1.52 mg of a hydrocortisone of the atseponat for 1 cm2 of skin once a day (that corresponds to two pressing of a raspylitelny head of a bottle a surface equivalent on plopad 10 h10 cm). Sleduyet to consult with the veterinarian in case more long-term treatment is required. By-effects it is not established. Preduprezhdeniye: It is forbidden to apply medicine on leather ulcers. Ne to allow hits of medicine on mucous membranes and in eyes of an animal. Glucocorticosteroids slow down growth, their application for young animals (up to 7 months) has to be based on risk advantage ratio assessment on condition of regular veterinary survey. Storage conditions: To store in the dry, started from direct sunshine place, separately from foodstuff and forages. A period of storage 24 months from the moment of production. A period of storage of 6 months after the first use. Producer: Virbac, France Product code: - Virbac Cortavance spray Sprey from an itch for dogs (76 ml) date editing the description: 19.08.2021