Valmisar And 160/5 tab. of p/o 160mg/5mg No. 30

Valmisar A - the combined medicament of inhibitors of angiotensin II, for treatment of essential hypertensia at adult patients whose arterial blood pressure is not regulated by monotherapy amlodipiny or valsartany.

Structure

• 1 tablet on 160 mg / 5 contains mg:
• active ingredients: valsartan 160 mg; an amlodipina of the besilat it is equivalent to an amlodipin of 5 mg; other components: microcrystalline cellulose, krospovidon, silicon dioxide colloidal anhydrous, magnesium stearate;
• covering of Instacoat Universal Yellow A05G11327: gipromeloza, polyethyleneglycol, talc, titan dioxide (E 171), ferrous oxide yellow (E 172).

Contraindication

• Hypersensitivity to active substance, derivatives of dihydropyridine or any of medicament excipients.
• Heavy abnormal liver functions, biliary cirrhosis or cholestasia.
• Accompanying use of the antagonists of receptors of angiotensin (ARA), including valsartan, or APF inhibitors with aliskireny to patients with diabetes or with renal failures (SKF <60 mg/min. / 1.73 sq.m).
• Pregnancy and planning of pregnancy.
• Heavy hypotension.
• Shock (including cardiogenic shock).
• Obstruction of an output path of a left ventricle (for example, hypertrophic subaortic stenosis and stenosis of an aorta of heavy degree).
• Hemodynamically unstable heart failure after an acute myocardial infarction.

Side reactions

Side reactions which were observed most often or were considerable or heavy: nasopharyngitis, flu, hypersensitivity, headache, faint, orthostatic hypotension, hypostases, hypostases of soft tissues, face edemas, peripheral hypostases, increased fatigue, reddening.

Patients at whom the ABP is inadequately regulated by monomedicaments of an amlodipin or valsartan can be transferred to

to combination therapy by medicament Valmisar A. The recommended dose - 1 tablet a day. Tablets Valmisar A can be taken irrespective of food. Valmisar is recommended to accept And, washing down him with a small amount of water.

Patients, applying valsartan and amlodipin separately, it is possible to translate on Valmisar And, containing the same doses of components.

to

Before transition to a combination of the fixed doses recommends individual selection of a dose with components (i.e. amlodipiny and valsartany). At clinical need it is possible to consider the possibility of direct replacement of monotherapy by a combination with the fixed doses.

Maximum daily dose – 1 tablet Valmisara A of 5 mg / 80 mg or 1 tablet Valmisara A of 5 mg / 160 mg or 1 tablet Valmisara A of 10 mg / 160 mg (the maximum allowed doses of components of medicament – 10 mg on the maintenance of an amlodipin, 320 mg behind the maintenance of a valsartan).

Use during pregnancy or feeding by a breast

Medicine it is contraindicated to pregnant women or women who are going to become pregnant to apply

Feature of use

As information on use of medicament Valmisar A during feeding by a breast is absent, medicament is not recommended to be used during feeding by a breast; it is desirable to use alternative medicaments with the studied safety profile, especially when feeding by a breast of newborn or premature children.

Children

treatment Research was not conducted by this medicament of children (up to 18 years). Therefore to obtaining fuller information Valmisar But is not recommended to apply to treatment of children.

Ability to influence speed of response at control of motor transport or other mechanisms

At the patients applying Valmisar And, can arise dizziness or weakness after administration of medicament therefore they have to consider it at control of motor transport and work with potentially dangerous mechanisms.

Amlodipin can have weak or moderate impact on ability to run motor transport or to work with other mechanisms. If patients during use of an amlodipin feel dizzy, headaches, fatigue or nausea, their reaction can be broken.

Overdose

Symptoms

Still is absent experience of overdose to A. Valmisar. The profound arterial hypotension with dizziness is the main symptom of overdose valsartan probably. The overdose of an amlodipin can lead to the accruing peripheral vazodilatation and probably reflex tachycardia. It was reported about the considerable and potentially prolonged system hypotension, up to shock and a lethal outcome.

recently, it is necessary to cause vomiting or to wash out a stomach. Absorption of an amlodipin considerably decreases at use of activated carbon at once or within two hours after reception of an amlodipin.

Clinically significant arterial hypotension caused by overdose to Valmisar And, demands active support of a condition of a cardiovascular system, including frequent control of warm and respiratory functions, raising of extremities, attention to OCK and urination. For restoration of a vascular tone and the ABP it is possible to use vasoconstrictive medicament in the absence of contraindications for its use. At permanent decrease in the ABP which is a consequence of blockade of calcium channels, can be reasonable intravenous administration of a gluconate of calcium.

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to Store

at a temperature not over 30C in original packing.

to Store

out of children's reach.