Capsules Utrozhestan are used at violations, connected with deficiency of progesterone.

Structure

Acting substance: progesterone;

1 capsule contains

progesterone micronized 100 mg or 200 mg;

Excipients: sunflower oil, lecithin soy, gelatin, glycerin, the titan dioxide (E 171), the water purified.

Contraindication

• hypersensitivity to medicine components;
• heavy violations of functions of a liver;
suspect or is confirmed to
• a neoplasia of a breast or genitals;
• not diagnosed vaginal bleedings;
• unsuccessful or incomplete abortion;
• thrombophlebitis;
• thromboembolic violations;
• cerebral hemorrhage;
• porphyria.

Route of administration

Duration of treatment depends on the nature of a disease.

In most cases the average daily dose makes 200-300 mg in 1 or 2 receptions (200 mg in the evening, before going to bed, and 100 mg in the morning if there is such need).

At insufficiency of a lyuteinovy phase (a premenstrual syndrome, violations of a menstrual cycle, a premenopause, fibrous and cystous mastopathy): accept within 10 days (usually from the 17th to the twenty sixth day of a cycle inclusive).

Use of progesterone after 36 weeks of pregnancy is not recommended to

.

Feature of application

Pregnant

medicine Use Utrozhestan not contraindicated at pregnancy, including in the first weeks. During use of medicine any case of adverse effect of medicine on a fruit was not observed. At use of medicine in the second and third trimesters of pregnancy the control of function of a liver is necessary.

Intake of progesterone in breast milk in detail was not studied by

. Therefore, its appointment should be avoided during feeding by a breast.

Children

Clinical data on use of medicine to children are absent.

Drivers

to Drivers of transport and operators of cars: the drowsiness and dizziness connected with administration of medicament internally are possible. Use of capsules before going to bed allows to avoid these unpleasant consequences. Cases of drowsiness and dizziness were observed only at oral administration of medicine.

Overdose

Symptoms of overdose can be shown by symptomatology of side reactions, including drowsiness, dizziness, euphoria, a dysmenorrhea, reduction of duration of a cycle, a metrorrhagia.

usual dose can be

At some persons excessive because of the existing or secondary emergence of unstable endogenous secretion of progesterone, hypersensitivity to medicament or very low accompanying oestradiol level in blood.

is enough

In such cases:

• to reduce a dose of progesterone or to appoint intake of progesterone in the evening before going to bed within 10 days for a cycle in case of drowsiness or fleeting dizziness;
• to transfer an initiation of treatment to later term in a cycle in case of its reduction or blood discharges;
to check
• whether oestradiol level at the patient who receives the substituted hormonal therapy in a premenopauza is sufficient.

Side effects

Frequent (> 1/100; <1/10) by-effects which were observed at oral administration:

• frustration of a reproductive system and mammary glands: change of periods, amenorrheas, the alternating bleedings;
• violation of the central nervous system: headaches.

At vaginal use of medicine reactions of hypersensitivity, including burning, an itch, hyperaemia and also emergence of oily discharges are possible

.

Interaction estrogen is strongly recommended

At hormonal therapy of a menopause by

prescribing of progesterone not later than for the twelfth day of a cycle.

If at treatment of threat of premature births Utrozhestan kombinuyetsya with beta адреномiметикамы, doses of the last it is possible to lower.

Simultaneous use of other medicines can change

progesterone metabolism, causing increase or decrease in concentration of progesterone in plasma and, respectively, to lead to change of effect of medicine.

Storage conditions

to Store

at a temperature not above 25 °C, out of children's reach.

Expiration date - 3 years.