Turning grays apply solution for injections to dogs and cats in cases of vomiting and emetic spasms. It can be caused as a motion sickness during transportation, and also because of poisoning or a disease, or at other pathologies which are followed by vomiting.

Advantage:

• According to clinical trials, solution of Turning gray differs in high bioavailability (90%) therefore it is soaked up very quickly, reaching peak concentration in 45 minutes after introduction.
Responses of owners and veterinarians also tell
• about efficiency of injections Turning gray from ukachivaniye, at poisonings and viruses: the favourite is quickly restored to former active life without nausea and vomiting.
• Usually animals well transfer medicine, side effects at its application do not arise.
• Entered vetpreparat exclusively hypodermically at the rate of 1 ml on 10 kg of body weight of an animal.
• According to the instruction it is inadmissible its use at puppies up to 8 weeks, kittens 16 weeks are younger, than females during pregnancy and feeding and also a productive animal.
Hozyaevs
• which give injections to pets independently have to watch own hygiene and safety.

it is strongly recommended to Use medicine after consultation with the veterinarian.

Structure and form of release:
Turning gray citrate – 10 mg, and as excipients – metacresol – 3.3 mg contains in 1 ml as active ingredient of the maropitant, sulfobutyl air of a β-tsiklodeksitrin of sodium – 63 mg and water for injections – to 1 ml. On appearance medicine represents transparent liquid of light yellow color. Medicine is packaged on 20 ml in the bottles from dark glass corked by the rubber traffic jams strengthened by aluminum caps. Bottles are packed into individual cardboard boxes. Put the instruction for its application in each box with medicine.

Pharmacological properties:
Turning gray treats to group of antiemetics.
Active ingredient Turning gray – the maropitant citrate – is an antagonist of neurokininovy receptors (NK1) and inhibits binding of substance P, a neytropeptid of takhikininovy group in central nervous system. Maropitanta citrate is effective at vomiting of both the central, and peripheral genesis. The Maropitant is quickly soaked up from the place of an injection and reaches the maximum concentration in blood plasma in 45 minutes after introduction. The Maropitant more than for 99% contacts proteins of plasma of blood. The bioavailability Turning gray is 90%. The Maropitant is metabolized in a liver by P450 cytochrome, allocated mainly with excrements.
On extent of impact on a maropitant organism citrate belongs to moderately dangerous substances (the 3rd hazard class in accordance with GOST 12.1.007-76).

Indication:
Appointed to dogs and cats for prevention of the vomiting caused by movement of an animal (motion sickness syndrome) and also at other pathologies which are followed by vomiting.

Dose and method of application:
Turning gray solution for injections are entered only hypodermically in a dose by 1 mg of the maropitant of citrate for 1 kg of weight of an animal that corresponds to 1 ml of medicine on 10 kg of mass of an animal, within no more than 5 days once a day. Symptoms of overdose are not established. Features of action at the beginning of introduction and cancellation of medicine are not revealed. It is necessary to avoid admissions at introduction of the next dose of medicine as it can lead to decrease in efficiency. In case of the admission of one dose it is necessary to renew a course of treatment in the dosages provided by the instruction and the scheme of application.

Side effects:
At application Turning gray according to the instruction of by-effects and complications, as a rule, it is not noted strong. At hyper sensitive animals allergic reactions are possible. In some cases note salivation, slackness, lack of appetite and a diarrhea. In case of allergic reactions use of medicine is stopped and appoint antihistamines and symptomatic treatment.

Contraindication:
Increased individual sensitivity to medicine components. It is forbidden to apply the pregnant and lactating animal. It is not recommended to puppies to appoint younger than 16 weeks age.

Special instructions:
recommended to be Used to Turning gray after consultation with the veterinarian. With care to appoint an animal with diseases of a liver and predisposition to diseases of a cardiovascular system. Data on interaction Turning gray with other medicines are absent.
Medicine is not intended for application to productive animals.

Measure of personal prevention:

1. During the work with Sereniya should follow the general rules of personal hygiene and safety measures provided during the work with medicines.
2. After work with medicine should wash up hands with soap.
3. At accidental contact of medicine with skin or mucous membranes of eyes them needs to be washed out a large amount of water.
4. People with hypersensitivity to components Turning gray should avoid direct contact with medicine.
5. in case of allergic reactions or accidental hit of medicine in a human body should address to medical institution (at itself to have the instruction for use of medicine or the label) immediately.
6. Empty bottles from under medicine is forbidden to be used for the household purposes, they are subject to utilization with household waste.

Storage conditions:
In the closed packing of the producer, in dry, protected from the sun, the place, inaccessible for children. Separately from food and forages at a temperature from 3ºС to 25ºС. A medicine expiration date at observance of storage conditions – 36 months from the date of production. After selection from a bottle of a part of medicine, on condition of observance of rules of an asepsis and the specified storage conditions, it can be reused, within 90 days. It is forbidden to apply Turning gray medicine after expiry date.
utilize Unused medicine according to requirements of the legislation.

Packing: 20 ml

Producer: Zoetis, Zoetis Inc., USA Species of an animalDogs
CatsCategory of veterinary medicineMedicines of other groupsArea of application of veterinary medicineOther types of diseases
Gastrointestinal diseasesMedicinesChemotherapeutic medicinesFormLiquid consistence