Pharmacological properties

Pharmacodynamics. active ingredient of medicament — tsitikolin — stimulates biosynthesis of structural phospholipids in a membrane of neurons, promotes improvement of functions of membranes, including functioning of ion-exchange pumps and neuroceptors. thanks to the stabilizing action on a membrane shows antiedematous properties therefore reduces wet brain. results of researches showed what tsitikolin suppresses activity of some phospholipases, interferes with residual emergence of free radicals, prevents damage of membrane systems and provides preservation of a protective antioxidant system. also reduces the volume of the damaged fabric, preventing death of cells by means of action on apoptosis mechanisms, and improves cholinergic transfer.

Thanks to the properties tsitikolin:

• has preventive neurotyre-tread effect in focal strokes of a brain;
• promotes fast functional rehabilitation of patients in acute disorders of cerebral circulation, reducing ischemic damage of tissues of brain that is confirmed by results of X-ray inspections;
• is reduced by duration of the recovery period and reduces intensity of a posttraumatic syndrome in craniocereberal injuries;
• promotes increase in level of brain activity, reduces amnesia level, improves a state in the cognitive, sensitive and motor disorders observed in brain ischemia.

Pharmacokinetics. After administration of medicament note substantial increase of level of sincaline in blood plasma. Drug is metabolized in intestines and a liver with formation of sincaline and cytidine. After introduction tsitikolin it is acquired by brain tissues, at the same time sincalines affect phospholipids, cytidine — on cytidine nucleoids and nucleic acids. Tsitikolin quickly reaches tissues of a brain and is actively built in cell membranes, cytoplasm and mitochondrions, activating activity of phospholipids.

with urine and a stake (3%) and about 12% — through airways. Removal of medicament with urine and through airways has two phases: the first phase — fast removal (with urine — during the first 36 h, through airways — during the first 15 h), the second phase — slow removal. The main part of a tsitikolin is involved in metabolism processes.

Indication

Sharp phase of disturbances of cerebral circulation and treatment of their consequences. craniocereberal injury and its consequences. the neurologic disorders (cognitive, sensitive, motor) caused by cerebral pathology of degenerative and vascular origin.

Use

Drug is used in/in or in oil. in a case in/in introductions medicament should be used in the form of slow in/in an injection (within 3–5 min. depending on the entered dose) or drop in/in injections (40–60 drops a minute).

Recommended dose for adults makes 500–2000 mg/days. The maximum daily dose — 2000 mg.

B the first 2 weeks use medicament in a dose 500–1000 mg 2 times a day in/in, further — 500–1000 mg 2 times in day in oil.

At acute and medical emergencies when prescribing medicament in the first 24 h

Recommended treatment duration with which the maximum therapeutic effect is observed — 12 weeks. In case of need to continue therapy tsitikoliny in a dosage form for oral administration. to Patients of advanced age of dose adjustment it is not required by

to p.

Dose of medicament and duration of treatment depend on weight of damages of a brain and are established individually.

Contraindication

Hypersensitivity to active ingredient or other components of drug. the raised tone of parasympathetic nervous system.

Side effects

from a cardiovascular system: ag, arterial hypotension, tachycardia.

from nervous system and mentality: profound headache, dizziness, hallucinations.

from a respiratory system: dispnoe.

from a digestive tract: nausea, vomiting, diarrhea.

from the immune system, skin and hypodermic cellulose: reactions of hypersensitivity, including rash, purpura, itching, Quincke's disease, acute anaphylaxis.

General disorders: a fever, hypostasis, fervescence, the increased sweating, changes in the injection site.

Special instructions

Drug should be used right after opening of an ampoule. the ampoule is intended only for single use. residues of medicament should be destroyed.

in case of steady intracraneal hemorrhage should not exceed a dose of a tsitikolin of 1000 mg/days and speed in/in injections of 30 drops in a minute.

Use during pregnancy and feeding by a breast. There are no sufficient data concerning use of a tsitikolin for pregnant women. It is unknown whether gets tsitikolin into breast milk. During pregnancy and feeding by a breast to use medicament in case the expected advantage for mother exceeds potential risk for a fruit.

Children. There are no sufficient data concerning use of a tsitikolin for children. To use medicament in case of need when the expected advantage of use exceeds potential risk.

Ability to influence speed of response at control of vehicles or other mechanisms. In some cases some side reactions from central nervous system can affect ability to run vehicles and other mechanisms.

Interaction

At simultaneous use of a tsitikolin and levodopa the effect of the last amplifies. it is not necessary to appoint medicament along with the medicines containing Meclofenoxatum.

Incompatibility. Drug should not be mixed with other medicines in one capacity.

Overdose

Is not present data relatively sluchav medicament overdose.

Storage conditions

In original packing at a temperature not above 25 °C. not to freeze.