Pharmacological properties

Pharmacodynamics. the peptide modulator tserebrokurin has positive impact on higher nervous activity by activation of the power producing and beloksinteziruyushchy function of neurons, increases in activity of the synoptic device of neurons.

Tserebrokurin promotes increase in diameter of mitochondrions, their area in unit of volume and to restoration of myelin covers in brain neurocytes which mosaic destruction happens at hypoxemic damage of neurocytes. Drug has nootropic and vasoactive effect, showing the regulating influence on bioelectric activity of a brain.

Tserebrokurin improves arterial and venous cerebral circulation. Nootropic, hypolipidemic, hepatoprotective, anabolitichesky action promotes a restitution of the broken central nervous system functions caused by both a functional, and organic lesion of a brain, normalization of emotional and mnestic functions expands the range of adaptation reactions that promotes physical, mental and social rehabilitation of patients with nervous and mental diseases.

stabilizing nootropic effect.

Pharmacokinetics. Studying pharmacokinetics is impossible as the active neuropeptids which are a part of medicament contain in an organism in the form of high-molecular proteins predecessors which biosynthesis happens during the post-natal period.

Indication

Disease, various forms of neurocirculatory dystonia, chronic ischemic distsirkulyatorny and posttraumatic encephalopathies, the residual phenomena of an acute disorder of cerebral circulation which are characterized by dysfunction of central nervous system, in particular.

as supportive application — after the undergone neurosurgical reconstructive operations on the main vessels of the head, in Alzheimer's disease, Binswanger's syndrome (ischemic periventrikulyarny ariolizm), at a syndrome of chronic fatigue and senile dementia of vascular genesis; dementias of the mixed forms, intellectual dynamic disturbances, a psychoorganic syndrome with intellectual insufficiency; encephalitis consequences; a Down syndrome, Rhett and Martin's syndromes — Bella.

In ophthalmologic practice — a senile makulodistrofiya (dry and damp forms), high degree of the complicated short-sightedness, states after amotio of a retina; partial atrophy of an optic nerve, posttraumatic makulodistrofiya; the central serous horioretinopatiya, not proliferative diabetic retinopathy without the profound hypostasis of macular area, glaucoma with the compensated intraocular pressure.

In pediatric practice — at a delay of mental development and the speech, a congenital alalia and dyslexia, stroke consequences with aphasia, a cerebral palsy with a psychospeech delay (not heavy degree), an apallichesky (dekortikatsionny) syndrome — during the subacute period and its consequences without frequent epileptic attacks, consequences of encephalitis or craniocereberal injury with disorders of intellectual functions and steady cephalalgias, sluggish paralyzes. During the neonatal period — in moderate and heavy asphyxia, consequences of a heavy chronic hypoxia.

Use

Tserebrokurin are entered by in oil.

on 2 ml daily. The minimum course of treatment — 10 injections. Patients with crushing organic lesions of a brain, Alzheimer's disease demand more long-term treatment; the course can be increased up to 40 injections, 2–3 times a year are recommended to carry out repeated courses.

In pediatric practice from the first days of life to 6-month age — on 0.5 ml every other day, on a course of treatment — 3–5 injections; aged from 6 months till 1 year — on 0.5 ml every other day, on a course of treatment — 10 injections; to children at the age of 1–3 years — on 1–2 ml every other day, a course — 10 injections; 3 years — 2 ml every other day, 10–20 injections are aged more senior. Repeated courses (2-4) in 1–3 months

Newborn and children under 3 years should carry out medicament treatment in the conditions of a hospital.

In ophthalmologic practice Tserebrokurin to enter in oil: on 2 ml daily or the first 5 injections in oil, then 1 ml peribulbarno, 1 ml in oil. To carry out injections daily, without interruption. The minimum course of treatment — 10 injections.

Children. In pediatric practice apply from the first days of life.

Contraindication

Increased individual sensitivity to medicament components, the period of pregnancy and feeding by a breast.

individual sensitivity to medicament components Is possible

. at use of medicine at treatment of patients with children's cerebral paralysis with symptomatic epilepsy such side reactions as increase of attacks, a headache, hyperexcitability are possible.

Special instructions

by

with care at tendency to an allergy. patients with the epileptic status and attacks should apply tserebrokurin under observation of the doctor.

to Children does not recommend to apply

Tserebrokurin for the night.

during medicament treatment should not take alcohol.

Use during pregnancy and feeding by a breast. Tserebrokurin is not recommended to apply during pregnancy and feeding by a breast.

Ability to influence the speed of reactions at control of vehicles or work with other mechanisms. Does not affect ability to run vehicles and to work with other mechanisms.

by

Interaction

Any interaction it was not observed.

Cases of overdose of medicament were not observed by

.

Storage conditions

In original packing at a temperature from +2 to +8 °C out of children's reach. not to freeze!