tablets "Trenaksa 500" are applied at the indication following:

• bleeding or risk of bleeding when strengthening a fibrinolysis as generalized (bleeding during operation and in the postoperative period on a prostate, hemorrhagic complications of fibrinolytic therapy), and local (uterine, gastrointestinal, nasal bleeding, posttraumatic a hyphema, bleeding after prostatectomy or intervention on a bladder, tonsilectomy, conization of a neck of the uterus, extraction of tooth at patients with hemophilia);
• hereditary Quincke's disease.

Structure

Active ingredient - traneksamovy acid (one tablet contains traneksamovy acid 500 mg).

Excipients: microcrystalline cellulose, povidone, sodium of a kroskarmelloz, silicon dioxide colloidal anhydrous, talc, magnesium stearate, titan dioxide (E 171), gipromelloza, propylene glycol, diethyl phthalate.

Contraindication

Hypersensitivity to medicament or other components of drug, a heavy renal failure, a macroscopic hamaturia, high risk of a thrombogenesis, thrombophlebitis; an active clotting disease, venous or arterial thrombosis in the anamnesis; myocardial infarction, subarachnoidal hemorrhage, acute venous or arterial thrombosis; fibrinolytic states after a coagulopathy owing to exhaustion, except for excessive activation of a fibrinolytic system in acute heavy bleeding; spasms in the anamnesis; disturbance of perception of flowers.

by

inside irrespective of meal.

Local fibrinolysis: the recommended dose - 1-1.5 g 2-3 times a day.

Prostatectomy: for prevention and treatment of a hemorrhage at patients with the increased risk before or after operations to appoint traneksamovy acid in the form of injections then to appoint in the form of tablets on 1 (two tablets on 500 mg) 3-4 times a day before disappearance of a macroscopic hamaturia.

Menorrhagia: the recommended dose - on 1 3 times a day no more than 4 days. In long menstrual bleeding to increase a dose, but not above maximum - 4 g a day (8 tablets on 500 mg). It is not necessary to begin medicament treatment prior to the beginning of menstrual bleeding.

Nasal bleedings: on 1 3 times a day within 7 days.

Conization of a neck of the uterus: on 500 mg 3 times a day duration up to 12 days.

Posttraumatic hyphema: the recommended dose makes on 1 3 times a day inside.

Hereditary Quincke's disease: some patients are informed on the course of exacerbations of a disease, to them reception on 1-1.5 g 2-3 times a day within several days suffices usually. Other patients should use medicament in the same dose depending on a course of the disease for a long time.

Extraction of teeth at patients with hemophilia: the recommended dose makes 25 mg/kg of traneksamovy acid in every 8 hours, beginning for one day before operation and continuing within 2-8 days after it.

Feature of use

Pregnant

Traneksamovaya acid gets through a placenta and into breast milk. The research on safety of use of medicament during pregnancy was not conducted therefore during this period it is possible to appoint medicament only when the expected advantage for mother exceeds potential risk for a fruit or the child. In case of need uses of medicament in the period of a lactation it is necessary to resolve an issue of the feeding termination by a breast.

Children

does not have clinical experience of use of traneksamovy acid to children and teenagers aged up to 15 years.

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Drivers

during use of medicament should refrain from control of motor transport or difficult mechanisms.

Overdose

Symptoms: nausea, vomiting, abdominal pain, orthostatic hypotension, arterial hypotension, dizziness, headache, spasms or strengthening of manifestations of other side reactions.

Treatment: to initiate vomiting, then gastric lavage and to carry out therapy by activated carbon. It is necessary to support high consumption of liquid to promote medicament removal by kidneys. Persons with tendency to fibrinferments have a risk of developing thromboses. It is necessary to consider treatments by anticoagulants.

Side effects

from a digestive tract: nausea, vomiting, heartburn, diarrhea which disappear at reduction of a dose, a loss of appetite, an abdominal pain.

from skin and hypodermic cellulose: rash, itching, urticaria.

from nervous system: drowsiness, dizziness, spasms, especially at misuse.

from an organ of sight: disturbance of color perception, disorder of vision, spasms, stagnant retinopathy, occlusion of veins/arteries of a retina of an eye.

from the immune system: reactions of hypersensitivity, including an anaphylaxis.

from vessels: arterial or venous thrombosis, thrombembolia, arterial hypotension.

from kidneys: acute necrosis of a bast layer of kidneys.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 2 years.