Trakhisan of the tab. No. 20

Pharmacological properties

Drug trakhisan contains a combination of the substances having antimicrobial properties and mestnoanesteziruyushchy action.

Tyrothricin is a mix of the different cyclic and linear (aliphatic) polypeptides operating antibacterially. Mix contains up to 70–80% of tyrocidin — alkaline cyclic decapeptide and 20–30% of gramicidin — neutral linear pentadecapeptide.

to release from bacterial cells of the substances containing nitrogen and phosphorus which like cationic detergents destroy an osmotic barrier of a membrane of a bacterial cell. Tyrocidin influences bakteritsidno the growing and sharing microorganisms.

Gramitsidin creates the kationoprovodyashchy channels in a cellular membrane of a bacterium leading to change of intracellular concentration of cations and a cytolysis. The Gramitsidinovy component promotes further separation of processes of tissue respiration and oxidizing phosphorylation.

Spectrum of action of tyrothricin extends to gram-positive cocci, bacteria and some species of mushrooms, for example Candida albicans.

Unlike antibiotics, at use of tyrothricin do not note cross resistance of microorganisms. This property is caused by the special mechanism of effect of tyrothricin.

Chlorhexidin and his salts have a wide range of antimicrobic action of rather gram-positive and gram-negative bacteria.

Mechanism of action of a chlorhexidin is based on its affinity to a cellular cover of microorganisms which properties change owing to contact with active agent.

Lipophilic groups of a chlorhexidin cause disaggregation of a lipoprotein membrane of a cellular cover, break osmotic balance in cages that destroys an activator cell cytoplasmic membrane.

Influence on some gram-negative bacteria (Pseudomonas, Proteus), yeast, dermatophytes and mycobacteria is insignificant. Chlorhexidin is inefficient against disputes of mushrooms, putrefactive mushrooms, viruses.

hydrochloride is local anesthetic of amide type. Drug causes blockade of natrium channels of nerve fibril owing to what process of depolarization of a membrane of a neuron through active potential is broken. At the same time transfer of excitement in fibers of sensory nerves is blocked.

At prolonged use (longer than several months) the efficiency of medicine decreases that, probably, is caused by changes of a bacterial range of microflora of an oral cavity and a tooth surface.

Indication

Inflammatory and infectious diseases of a mouth and throat, such as stomatitis, ulitis, periodontal disease, glossitis, tonsillitis, pharyngitis, and other states which are followed by swallowing violation. for prevention of infections before and after surgical intervention on sites of a mouth and throat (extraction of tooth, surgical treatment of gums, tonsilectomy).

to Accept

on 1 tablet trakhisan, rassasyvy in an oral cavity each 2 h the daily dose for adults and children is aged more senior than 12 years — 8 tablets; for children aged from 4 up to 12 years — 6 tablets. as a rule, symptoms of a disease disappear in several days, but for achievement of stable therapeutic effect it is recommended to continue therapy of 2-3 more days if in 5 days of use of medicine the condition of the patient does not improve, consultation of the doctor of rather further treatment is necessary.

Continuous application of tablets for resorption Trakhisan without medical prescription can proceed no more than 2 weeks

Children. Do not recommend to apply at children under 4 years as medicine needs to be rassasyvat.

Contraindication

Hypersensitivity to components of medicine or to other amide mestnoanesteziruyushchy medicines. erosive and desquamative changes of a mucous membrane of an oral cavity, fresh wounds of the big sizes in an oral cavity and throat, intolerance of fructose.

Side effects

reactions of hypersensitivity, including: local irritation, throat hypostasis, face edema, itch, small tortoiseshell, skin rashes or asthma.

Perhaps short-term change of taste, temporary numbness of language which disappear independently after the termination of administration of drug. At prolonged use in isolated cases perhaps insignificant coloring in yellow or light brown color of teeth, fillings and prostheses or language, it is possible to get rid by means of hygiene of an oral cavity.

Special instructions

Trakhisan does not contain some sugar in the structure and therefore does not promote developing of caries of teeth. patients can use medicament with diabetes, using sorbite sweetener recalculation on he (0.69 g of sorbite correspond 0.057 he).

Period of pregnancy and feeding by a breast. Data on negative impact of medicine during pregnancy and feeding by a breast did not arrive. However special researches in this category of patients were not conducted. Therefore before use of medicine the doctor has to weigh a ratio risk/advantage for this group of patients.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Does not influence.

are not revealed by

Interaction

Cases of overdose are not described by

. at accidental use of excessive quantity of tablets it is recommended to wash out a stomach. symptomatic treatment.

Storage conditions

At a temperature not above 25 °C in the dry place.