Pharmacological properties

Pharmacodynamics. xylomethazolinum is the sympathomimetic agent acting on α-adrenergic receptors.

Xylomethazolinum at nasal application causes narrowing of blood vessels of a mucous membrane of a nose and adjacent sites of a nasopharynx, eliminating thus hypostasis and hyperaemia of a mucous membrane of a nose and nasopharynx and also reduces the increased mucifying connected with it and facilitates removal of the blocked discharges from a nose that leads to cleaning of nasal passes and simplification of nasal breath.

in 2 min. after application and remains up to 12 h

Drug well is transferred, including patients with a sensitive mucous membrane, and does not reduce mukotsiliarny function. Results of laboratory analyses demonstrate that xylomethazolinum reduces infectious activity of a rhinovirus of the person which is associated with common cold.

Thanks to moisturizing components (sorbitol, a gipromelloz) the medicine Pharmazolin with mint and an eucalyptus, spray nasal, helps at dryness and irritation of a mucous membrane of the nasal courses. Drug has the balanced value rn in the limits inherent to a nasal cavity.

Pharmacokinetics. At topical administration, medicine is almost not absorbed, concentration of xylomethazolinum in blood plasma so low that are almost not defined (concentration in blood plasma is close to a definition limit).

Xylomethazolinum has no mutagen properties. Also in researches on animals the teratogenic influence of xylomethazolinum is not revealed.

Indication

Symptomatic treatment of congestion of a nose at cold, hay fever, at other allergic rhinitises, sinusitis; for simplification of outflow of a secret at diseases of adnexal bosoms of a nose; auxiliary therapy in cases of average otitis (for elimination of hypostasis of a mucous membrane); for simplification of carrying out a rinoskopiya.

Use

to Adults and children is aged more senior than 12 years: on 1 injection in each nasal course up to 3 times a day.

no more than 3 times in each nasal course in day. Duration of treatment depends on a course of the disease and should not exceed 10 days in a row.

accuracy of dosing and appropriate distribution of solution on a nose cover mucosal surface. At each injection 0.14 g of solution are entered that corresponds to 0.14 mg of xylomethazolinum.

Before application needs to set ready the portioning device by implementation of several injecting movements until spray begins to be emitted in air. At further application the portioning device will be ready for immediate application.

needs to Apply spray as follows:

• a nose before use of medicine;
• should hold a bottle vertically, supporting a bottom by a thumb and having a tip between two fingers;
• slightly to incline a bottle and to insert a tip into a nostril;
• to carry out injection and at the same time to execute an easy breath through a nose;
• after application before closing a tip a cap, it is necessary to clean and dry up a tip;
for prevention of infection each bottle with medicine only one person has to use
• .

Last application is recommended to be carried out just before a dream.

Contraindication

Hypersensitivity to xylomethazolinum or to any other component of medicine, sharp coronary diseases, coronary asthma, a hyperthyroidism, closed-angle glaucoma, transfenoidalny hypophysectomy and surgical interventions with exposure of a meninx in the anamnesis, dry rhinitis (rhinitis sicca) or atrophic rhinitis. the accompanying treatment by Mao's inhibitors and during 2 weeks after the termination of their application.

Side effects

from the immune system: seldom (1/10,000) — reactions of hypersensitivity, including a Quincke's disease, rash, the naggers;

from nervous system: often (from 1/100 to 1/10) — a headache;

from an organ of sight: seldom (1/10,000) — a temporary disorder of vision;

from a cardiovascular system: seldom (1/10,000) — irregular or a cardiopalmus;

from respiratory organs, a thorax and mediastinum: often (from 1/100 to 1/10) — dryness or discomfort from a mucous membrane of a nose;

from digestive system: often (from 1/100 to 1/10) — nausea;

general violations and reactions in the injection site: often (from 1/100 to 1/10) — burning sensation in the site of application.

Special instructions

should not use Drug longer than 10 days in a row. too prolonged or excessive use can lead to resuming of congestion of a nose and/or a mucosal atrophy of a nose.

Drug, as well as other sympathomimetics, it is necessary to appoint with care to the patients having strong reactions to adrenergic means which are shown by insomnia, dizziness, a shiver, cardiac arrhythmia or increase in the ABP.

should not exceed the recommended medicine dose, especially at treatment of children and elderly people.

with care medicine to patients with cardiovascular diseases, AG, sick diabetes, with hyperfunction of a thyroid gland, a pheochromocytoma, a prostatauxe and also not to apply at the accompanying treatment by MAO inhibitors and during 2 weeks after the termination of their application.

Drug the benzalkoniya contains chloride which can cause a bronchospasm.

Use during pregnancy or feeding by a breast. Drug cannot be used during pregnancy because of potential vasoconstrictive effect.

Proof of any undesirable influence on the baby are absent. It is unknown whether xylomethazolinum in breast milk is excreted therefore the care is necessary, during feeding by a breast medicament should be used only on doctor's orders.

Fertility. Appropriate data on influence of the medicine Pharmazolin with mint and an eucalyptus on fertility are absent. As system exposure of xylomethazolinum of a hydrochloride very low, the probability of influence on fertility is extremely small.

Children. Not to use medicament to children aged 12 years are younger.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Usually medicine has no or has insignificant impact on ability to steer vehicles or to work with other mechanisms.

Interaction

Mao's Inhibitors: xylomethazolinum can exponentiate effect of inhibitors of Mao and induce hypertensive crisis. not to apply xylomethazolinum to patients who accept or accepted Mao's inhibitors during the last 2 weeks

Three - and tetracyclic antidepressants: at simultaneous application three - or tetracyclic antidepressants and sympathomimetic medicines strengthening of sympathomimetic effect of xylomethazolinum is possible therefore simultaneous application of these means is not recommended.

.

Overdose

inside can lead Excessive topical administration of xylomethazolinum of a hydrochloride or its accidental hit to developing of the expressed dizziness, perspiration, considerable decrease in body temperature, a headache, bradycardia, ag, to depression of respiratory, a coma and spasms. raised hell can change on lowered. children of younger age are more sensitive to overdose, than adults.

relevant supporting activities and also, in case of need, urgent symptomatic treatment under medical control to overdose. Medical care has to include observation of the patient within several hours. In case of the heavy overdose which is followed by cardiac arrest, resuscitation actions it is necessary to continue not less than 1 Part

Storage conditions

In original packing at a temperature not above 25 °C.