Levofloxacin - synthetic antibacterial medicine from group of ftorkhinolon, is S (-) an enantiomer of racemic mix of medicine of an ofloksatsin.

As antibacterial agent from group of ftorkhinolon levofloxacin affects complex DNK-DNK-girazu and IV topoisomerase.

Drug to appoint

adult for treatment of the following infections:

• Acute bacterial sinusitis.
• Exacerbation of chronic bronchitis.
• Community-acquired pneumonia.
• Complicated infections of leather and soft tissues.

In above-mentioned infections medicament should be used only when it is considered inexpedient to use antibacterial medicaments which are usually recommended for initial treatment of these infections.

• Complicated urinary tract infections (including pyelonephritis).
• Chronic bacterial prostatitis.
• Neuskladneny cystitis.

Drug can be also used by

for end of a course of therapy at patients at whom improvement is shown during initial treatment levofloksatsiny intravenously.

Should consider official recommendations about ought use of antibacterial medicines.

Contraindication

Hypersensitivity to a levofloksatsin, other hinolon or to medicine excipients.

Epilepsy.

Existence in the anamnesis of damages of a sinew owing to reception of ftorkhinolon.

Children's age.

Period of pregnancy and feeding by a breast.

Route of administration and doses

to take the Drug 1 or 2 times a day. The dose depends on type, weight of an infection and sensitivity of the probable activator.

for end of a course of therapy at patients at whom improvement is shown during initial treatment levofloksatsiny intravenously; considering bioequivalence of parenteral and oral forms, it is possible to apply identical dosing.

Dosage . The following recommendations concerning a dose can be provided for medicine:

Dosing for patients with normal function of kidneys (clearance of creatinine> 50 ml/min.)

* As the tablet does not share mg (Depending on weight), in case of prescribing of medicine in a dose of 250 mg or it is necessary to use medicaments of a levofloksatsin with a possibility of such dosing less.

Overdose

Symptoms. The major signs which should be expected after sharp overdose of a levofloksatsin, symptoms from the central nervous system, including confusion of consciousness, a hallucination, a tremor, dizziness, violation of consciousness and convulsive attacks, lengthening of an interval of QT and also gastrointestinal reactions, such as nausea and erosion of a mucous membrane.

Treatment. In case of overdose to carry out symptomatic treatment. It is necessary to carry out monitoring of the ECG as there is a possibility of lengthening of an interval of QT. For protection of a mucous membrane of a stomach it is possible to use antacids. The hemodialysis, including peritoneal dialysis and HAPD, are not effective for removal of a levofloksatsin from an organism. There are no specific antidotes.

Special instructions

Use during pregnancy or feeding by a breast

Pregnancy.

.

data on a research on animals who do not point to direct or indirect harmful effects on reproductive toxicity Exist. However due to the lack of researches of impact on a human body and on the basis of the experimental data indicating risk of damage of a ftorkhinolonama of an articulate cartilage of the growing organism, it is impossible to appoint levofloxacin pregnant.

feeding Period breast.

nursing. Information on penetration of a levofloksatsin into breast milk is not enough though other ftorkhinolona are excreted in breast milk. Due to the lack of researches with participation of people and damage of a ftorkhinolonama of an articulate cartilage of the growing organism is possible, it is impossible to appoint levofloxacin nursing.

Fertility.

Knows that levofloxacin would not lead to disorders of fertility and reproductive function at rats.

Children

Drug is contraindicated to children aged up to 18 years.

Some side reactions (for example, dizziness / vertigo, drowsiness, a disorder of vision) the ability of the patient to concentration of attention and speed of its reaction can break

and, thus, to cause the increased risk in situations when these qualities are of especially great importance (for example, during the driving of the car or control of mechanisms).

Structure

active ingredient: levofloxacin (levofloxacin)

1 tablet supports a levofloksatsin gemigidrat in terms of levofloxacin of 500 mg

Excipients: K29/32 povidone, cellulose microcrystalline, krospovidon, magnesium stearate, silicon dioxide colloidal, Opadry 03B84681 covering pink: gipromelloza, titan dioxide (E 171), polyethyleneglycol, ferrous oxide red (E172), ferrous oxide yellow (E 172).

to Store

at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date - 3 years.