Stronghold large dogs (20.1-40.0 kg) the pipette of 240 mg (2 ml) the Most convenient in application antiparasitic a preparatudobny dosage form of medicine - a spot - it - provides simple and easy putting medicine on skin of an animal along a backbone from a nape prior to the beginning of a tail (it is necessary to drip evenly from withers to a tail root on skin). The composition of solvents and form-building does not include oil in this connection after putting medicine leather and animal hair quickly dry that allows the owner to touch an animal and to play with it already in half an hour after putting medicine. The medicine "Stronghold" (for Europe) and "Revolution" (for the USA) on the basis of a selamektin kills adult fleas and stops an incubation of eggs of these insects, removes ear and scabby pincers, destroys the dirofilyariya affecting heart, expels roundworms (ascarids and toksokara) and hookworms. One drop will protect your pets from external and internal parasites (fleas, ear and scabby pincers, round helminths). Medicine quickly dries, vlagoustoychiv and has no unpleasant smell so you can embrace and play with your cat or a dog right after drying. The efficiency of medicine remains even if you will bath a dog in two hours after application. It is safe for puppies and kittens since 6 week age, even in case of the 10th multiple overdose. Tested on 167 breeds of dog and 18 cat breeds, including ivermectin of sensitive collies and from a hybrid. Stronghold in the first day saves an animal from fleas and within one month protects from repeated infection. Selamektin (this Strongkholda active agent) destroys mature fleas and eggs, preventing appearance of new generation of parasites. The first endektotsid, specially developed for dogs and cats. Active ingredient of Stronghold - selamektin. This new semi-synthetic avermektin was selected from more than 700 molecules and specially developed for application on dogs and cats. It is intended for fight with ekto- and endoparasites at dogs and cats, is safe for animal all breeds and pedigree hybrids (including a collie type, bobtails and boxers). The safest way of extermination of parasites - Selamektin interacts with receptors of chloric channels that causes the termination of normal momentum transfer in neuromuscular synapses in parasites. It leads to violation of electric activity of nervous cages at helminths and muscle cells of arthropods therefore there is paralysis and death of parasites. At mammals the similar receptors of chloric channels are only in central nervous system, and thanks to high selective permeability of a hematoencephalic barrier, they are inaccessible for large molecules of a selamektin, unlike similar receptors of nematodes and arthropods. This feature of a selamektin causes high degree of safety for mammals. Stronghold is quickly absorbed from the place of drawing and distributed with blood current. Selamektin is soaked up from the place of drawing and its concentration in plasma of blood reaches a maximum at cats in 1 day and at dogs in 3 days after processing. Dogs and cats can be bathed in 2 hours after putting medicine, at the same time its efficiency does not decrease. Selamektin with a blood-groove gets to all bodies and fabrics, at the same time therapeutic concentration of medicine in plasma of blood of dogs and cats remains within 30 days after drawing in a single dose of 6 mg/kg. Long circulation and slow allocation from an organism provides long elimination half-life - 8 days for cats and 11 days for dogs. Selamektin in large numbers collects in sebaceous glands and long time is allocated with their secret that provides long effect of medicine against fleas, ear pincers and scabby pincers. Therapeutic concentration of medicine against ektoparazit remains within 30 days. High efficiency in the relation ekto- and endoparasites. The excellent profile of safety of Dl of animals Is safe for puppies and kittens since 6 weeks age, even in case of 10-fold overdose Is tested on 167 breeds of dog and 18 cat breeds, including ivermectin - sensitive collies and their hybrids Within 6 years of clinical trials more than 12000 doses of the medicine Medicine were around the world applied it is safe even in case by mistake instead of drawing on skin drug was injected orally Dl people in 30 minutes after putting medicine on skin to an animal as soon as it dries, you can touch an animal and play with it. Dlya putting medicine is not required to put on protective gloves or protective clothes. It is easy to open medicine package, but at the same time the child will not be able to make it. Unlike the majority of medicines for fight against ektoparazita, Stronghold is exclusively pharmaceutical medicine which does not have agrochemical analogs is Completely compatible to all vaccines and the veterinary medicines Stroigkholds Compatibility was confirmed more than on 1800 dogs and 1190 cats which before vaccination by various vaccines appointed Stronghold Not only adult fleas, but also eggs and lichinkistrongkhold destroys adult fleas who are on dogs or cats, in 24-36 hours after putting medicine, and protects from a repeated invasion within 30 days. Ovitsidny effect of medicine interrupts a cycle of development of a parasite and does not give the chance to appear the following generation of fleas. Monthly use of medicine not only directly protects animals from an infestation, but also reduces residual population of fleas in the house or the apartment. Preparat can be used also as one of components in treatment of flea allergic dermatitis. Treatment and profilaktikav experiments which were made in strictly controlled conditions Strongholds efficiency against fleas was 99% and 98% for dogs and cats respectively within 30 days. Dlya of animals who continue to be in conditions of a possible repeated infestation is recommended monthly use of medicine. Destroys fleas not only on animals, but also in the environment. Stronghold provides full protection of animals, families and dwellings. At any stage of a cycle of development of fleas only 5% of population are made by adult insects who are on an animal; other 95% of population are in rooms: in floor cracks, under plinths, in carpets, etc. These not mature stages are a constant source of a reinfestation of animals and one of the causes of flea allergic dermatitis. Numerous experiments show that application only of Stronghold can significantly reduce presence of fleas in the dwelling. Since the first drawing Stronghold from 30 to 60 days (that is, 1-2 multiple drawing Stronghold) can be necessary for sharp decrease in amount of eggs and larvae of fleas in the dwelling. Pilot studies with artificial infection of the room show that by 60th day after the first use of medicine the infection of the room decreases by 97%, and by 90th day for 98.4%. Stronghold has very high efficiency against adult fleas which he destroys within 24-36 hours after drawing. As a result the amount of the laid eggs decreases by 99%. More than 96% of the eggs laid by fleas who ate on the animals processed by Stronghold will not be able to develop. Larvae which were brought out of the eggs which got to the environment prior to processing of animals perish soon after hatching as a result of contact with detrity which falls to the environment from the animals processed by Stronghold. Larvae which begin to eat excrement of fleas and detrity the animals processed by Stronghold stop development and soon perish. Only one drop protects people from dangerous zoonoz. Ear chesotkastrongkhold it is highly effective for therapy of the ear itch caused by Otodectes cynotis, even after single application. Effektivnost of medicine was confirmed in numerous researches which were conducted both in controlled conditions of research laboratories, and in the conditions of usual clinic. In 30 days after Strongholds appointment at one of the processed cats live flares were not revealed that confirms to 100% efficiency of medicine in vitro. At dogs it is recommended to appoint medicine repeatedly, in a month after the first application. Sarkoptoz at sobakstrongkhold is effective for suppression of the sarkoptoz at dogs caused by scabby pincers (Sarcoptes scabiei), at the same time it is recommended to appoint it twice from 30 a day interval between processings. In the experiments made both in the conditions of clinic and in strictly controlled laboratory conditions, at therapy of spontaneous infection the therapeutic action of Stronghold was compared to usual methods of treatment. In a month after drawing the first dose of medicine at a research of scrapes of skin the efficiency of medicine was 93.5% (at one dog 1 tick was found), in 30 days after drawing the second dose the efficiency of medicine was 100%. Regions DirofilyariozV with warm climate, including the southern regions of Russia, dirofilyarioz, the caused Dirofilaria immitis, is very serious parasitic disease of dogs and cats. At Strongholds application once a month during the season of summer of mosquitoes carriers medicine completely warns infection of dogs and cats, killing mikrofilyariya and preventing their transformation into adults of nematodes. As medicine does not kill adult dirofilyariya, its application is absolutely safe at invazirovanny animals. To secure animals which are imported into regions where it is widespread dirofilyarioz it recommends to appoint a month before estimated date of import Stronghold. One dose of Stronghold kills not only adult nematodes, but also has ovitsidny activity. Toxocara canisstrongkhold is effective against adult Toxocara canis even after its single application. Puppies can appoint medicine since 6 weeks age. Preparat the pregnant and lactating females can also appoint. The most convenient in application antiparasitic a preparatudobny dosage form of medicine - a spot - it - provides simple and easy putting medicine on skin of an animal along a backbone from a nape prior to the beginning of a tail (it is necessary to drip evenly from withers to a tail root). The composition of solvents and form-building does not include oil in this connection after putting medicine leather and animal hair quickly dry that allows the owner to touch an animal and to play with it already in half an hour after putting medicine. date editing description: 05.10.2021