Pharmacological properties

Pharmacodynamics

Streptocide, as well as other streptocides, breaks education in microorganisms of growth factors — folic, degidrofoliyevy acids, other connections containing in the molecule pabk. owing to proximity of its structure to that of streptocide, the last as the competitive antagonist of the mentioned acid joins in a metabolic chain and breaks processes of exchange in microorganisms, showing bacteriostatic effect. medicament belongs to streptocides of short action. streptocide has bacteriostatic action concerning streptococci, meningokokk, pneumococci, gonokokk, colibacillus, causative agents of toxoplasmosis and malaria. by efficiency considerably concedes to modern antibiotics. now very many strains of microorganisms, especially hospital, are resistant to streptocide.

Activity of streptocide increases in the alkaline environment.

enterococci, a pyocyanic stick, anaerobe bacterias Are insensitive

to streptocide.

Pharmacokinetics

inside is quickly soaked up by

At use: The C _max in blood plasma is reached in 1–2 h, medicine is defined by 4 h in SMZh. Decrease in the C _max in blood for 50% happens less than for 8 h. Kidneys allocate about 95% of drug.

Indication

Infectious and inflammatory diseases caused by microorganisms, sensitive to medicine: infectious diseases of skin and mucous membranes (wounds, ulcers, decubituses), coloenteritis, pyelitis, cystitis.

Use

to Accept

inside in time or after a meal, washing down 150–200 ml of water. the single dose for adults and children is aged more senior than 12 years makes 600 mg — 1.2 g, a daily dose — 3–6 g a daily dose should be distributed on 5 receptions.

to Children at the age of 3–6 years — 300 mg on 1 reception, 6–12 years — 300–600 mg on 1 reception. The frequency rate of reception for children is 4–6 times a day.

Duration of treatment is defined by

individually and depends on weight and a course of the disease, localization of process, efficiency of therapy.

Highest doses for adults: single — 2 g, daily — 7 g

Maximum daily dose for children — 900 mg — 2.4 g

Contraindication

Individual sensitivity to streptocides, sulphones and other components of medicine; existence in the anamnesis of the significant toksiko-allergic reactions to streptocides;

• a nefroza, nephrites;
• a bazedov disease;
• acute hepatitises;
• oppression of a marrowy hemopoiesis;
• renal and/or liver failure;
• dekompensirovanny chronic heart failure;
• congenital deficit glyukozo-6-fosfatdegidrogenazy, porphyria;
• a disease of the haematogenic system: anemia, leukopenia;
• hyperthyroidism;
• azotemia.

Side effects

from the system of blood and lymphatic system: a leukopenia, an agranulocytosis, aplastic anemia, thrombocytopenia, a prothrombinopenia, an eosinophilia, hemolytic anemia at deficit glyukozo-6-fosfatdegidrogenazy.

from a cardiovascular system: tachycardia, myocarditis.

from nervous system: a headache, neurologic reactions, including aseptic meningitis, an ataxy, insignificant intracranial hypotension, spasms, dizziness, drowsiness/insomnia, feeling of fatigue, a depression, peripheral or optical neuropathy, a disorder of vision, psychosis, depression, paresthesias.

from a respiratory system: pulmonary infiltrates, fibroziruyushchy alveolitis.

from a digestive tract: thirst, dryness in a mouth, the dispeptic phenomena, nausea, vomiting, diarrhea, anorexia, pancreatitis, pseudomembranous colitis.

from a gepatobiliarny system: increase in activity of liver enzymes (AlAT, AsAT, SF), cholestatic hepatitis, gepatonekroz, hepatomegalia, jaundice, cholestasia.

from an urinary system: urine discoloration (saturated yellowy-brown color), a crystalluria at acid reaction of urine; nephrotoxic reactions are possible: interstitial nephrite, tubular necrosis, a renal failure, a hamaturia, a shock kidney with an anury.

from skin and hypodermic cellulose: dermahemia, skin rash (including erythematic and squamous, papular), itching, urticaria, allergic dermatitis, photosensitization, exfoliative dermatitis, knotty erythema, cyanosis.

from the immune system: reactions of hypersensitivity, including a toxic epidermal necrolysis (Lyell's disease), Stephens's syndrome — Johnson, a system lupus erythematosus, a serumal syndrome, anaphylactic reactions, a Quincke's edema, cold.

General disturbances: medicamentous fever, pain in right hypochondrium and a waist.

Others: the complicated breath, a nodular periarteritis, a hypothyroidism, a hypoglycemia.

Special instructions

streptocide needs to carry out by

At treatment systematic control of function of kidneys and indicators of peripheral blood, glucose level to blood.

medicament needs to carry out by

At long-term treatment periodically blood test (biochemical and general blood tests). Prescription of medicine in insufficient doses or early phase-out of medicine can lead to increase in stability of microorganisms to streptocides.

should not apply Streptocides to treatment of the infections caused by a beta and hemolytic streptococcus of group A as they do not cause its eradikation and, therefore, cannot prevent such complications as rheumatism and a glomerulonephritis.

needs to appoint Medicine by

with care the patient with chronic heart failure, diseases of a liver and a renal failure. In a renal failure the cumulation of streptocide and its metabolites in an organism is possible that it can lead to development of toxic effect.

should appoint

Streptotsid-Darnitsa with care to patients with a severe form of allergic diseases or bronchial asthma, with diseases of a system of blood. At emergence of signs of hypersensitivity reaction, medicine should be cancelled.

With care should apply streptocides, including streptocide, at patients with diabetes as streptocides can affect glucose level in blood. High doses of streptocides have hypoglycemic effect.

As streptocides are bacteriostatic, but not bactericidal drugs, the full-fledged course of therapy is necessary for prevention of a recurrence of an infection and development of steady forms of microorganisms.

Considering similarity of chemical structure, streptocides cannot be applied at persons with hypersensitivity to furosemide, thiazide diuretics, inhibitors of a karboangidraza and derivatives of sulphonylurea.

to Patients needs to use enough liquid for prevention of a crystalluria and development of an urolithiasis. it are noted by

At elderly people p the increased risk of development of heavy undesirable reactions from skin, oppression of a hemopoiesis, Werlhof's disease (the last — especially at a combination to thiazide diuretics).

Should avoid prescription of medicine to patients aged 65 years in connection with the increased risk of emergence of heavy side reactions are more senior.

Is recommended to avoid influence of direct sunshine and artificial ultra-violet radiation in view of a possibility of development of a photosensitization at use of streptocides.

during treatment needs to observe the dosing mode, to apply the recommended dose at an interval of 24 h, not to miss reception. In case of the admission of a dose not to double the following dose.

If symptoms of a disease do not begin to disappear or, on the contrary, the state of health will worsen or there will be undesirable phenomena, it is necessary to suspend use of medicine and to see behind consultation a doctor of rather further use of medicine.

Use during pregnancy and feeding by a breast. Medicine is contraindicated during pregnancy or feeding by a breast.

In need of medicine use feeding by a breast should be stopped.

Children. To apply medicine at children aged 3 years are more senior.

Ability to influence speed of response at control of vehicles and other mechanisms. There is no information on influence of medicine on ability to run vehicles and to work with difficult mechanisms.

Before clarification of individual reaction to medicine should abstain from control of vehicles or other mechanisms as at treatment by streptocides such side reactions from nervous system are possible as dizziness, spasms, an ataxy, drowsiness, a depression, psychoses.

Interaction

At simultaneous use with:

NPVP, sulphonylurea derivatives, antitrombotichesky means, antagonists of vitamin K — effect of these medicaments amplifies;

folic acid, bactericidal antibiotics (including penicillin, cephalosporins) — the efficiency of streptocides decreases;

bactericidal antibiotics, oral contraceptives — effect of these medicaments decreases;

p-aminosalicylic acid and barbiturates — the activity of streptocides amplifies;

derivative pyrazyl ketone, indometacin and salicylates — the activity and toxicity of streptocides amplifies;

a methotrexate and dipheninum — the toxicity of streptocides amplifies;

erythromycin, lincomycin, tetracycline — the antibacterial activity mutually amplifies, the spectrum of action extends;

rifampicin, streptomycin, Monomycinum, Kanamycinum, gentamycin, oxyquinoline derivatives (nitroxoline) — antibacterial effect of medicaments does not change;

by

Acidum nalidixicum (Nevigramonum) — sometimes observe antagonism;

chloramphenicol, nitrofurans — the cooperative effect decreases;

by

medicaments containing ethers of paraaminobenzoic acid (novocaine, anaesthesin, Dicainum) — inactivates antibacterial activity of streptocides.

should not appoint Sulfaniamida's

along with hexamethylenetetramine (urotropin), anti-diabetic medicaments (sulphonylurea derivatives), dipheninum, neodicoumarin and other indirect anticoagulants.

Streptocide can enhance effect and/or toxicity of a methotrexate owing to replacement it from communication with proteins and/or weakening of his metabolism.

At simultaneous use with other medicaments which cause oppression of marrow, hemolysis, hepatotoxic action the risk of development of toxic effects is possible

.

to

does not recommend simultaneous use with methenamin (urotropin) owing to increase in risk of development of a crystalluria at acid reaction of urine.

Phenylbutazone (Butadionum), salicylates and indometacin can force out streptocides from communication with proteins of blood plasma, thereby increasing their concentration in blood. At use together with p-aminosalicylic acid and barbiturates the activity of streptocides amplifies; with levomycetinum — risk of developing an agranulocytosis increases.

Overdose

strengthening of manifestations of side effects Is possible

.

At overdose the developing of anorexia (lack of appetite), nausea, vomitings, kolikoobrazny pain, a headache, drowsiness, dizziness, faints is possible

. At prolonged use the fever, a hamaturia, a crystalluria, cyanosis, tachycardia, paresthesias, diarrhea, a cholestasia, a renal failure with an anury, toxic hepatitis, a leukopenia, an agranulocytosis are possible.

Treatment. In case of overdose it is recommended to see a doctor. Before delivery of health care a stomach to wash 2% with solution of Natrii hydrocarbonas and to accept suspension of the coal activated or other enterosorbents. The use of a large amount of liquid, an artificial diuresis, a hemodialysis are shown. Symptomatic treatment.

Storage conditions

In original packing at a temperature not above 25 °C.