Pharmacological properties

Sterokort at topical administration reduces expressiveness of inflammatory and allergic reactions of skin and also the reactions connected with hyper proliferation of cells promotes elimination as objective symptoms (erythema, hypostasis, infiltration, lichenification), and subjective complaints (itching, burning, pain).

When putting Methylprednisolonum of the atseponat in a dose which is effective for topical administration, system effect minimum both at people, and at animals. When drawing on big sites of skin at patients with skin diseases the cortisol level in blood plasma within a day remains within norm, also its circadian rhythm does not change. Also decrease in concentration of cortisol in the daily volume of urine is not revealed.

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As well as in case of other GKS, the mechanism of effect of Methylprednisolonum of the atseponat is finally not found out. It is known that it directly contacts intracellular GKS-receptors. It especially concerns the main metabolite — 6α-метилпреднизолона-17-пропионата, the splitting which is formed later in skin.

Binding of a complex a receptor — steroid with a certain site of molecule DNA initiates a number of biological effects.

Mechanism of anti-inflammatory action is installed to

more precisely. Binding of a complex a receptor — steroid leads to macrocortinum synthesis induction. Macrocortinum inhibits release of arachidonic acid and, thus, formation of mediators of inflammation, such as prostaglandins and leukotrienes reduces.

can explain Immunosuppressive action of GKS to

with inhibition of synthesis of cytokines and antimitotic effect which is still insufficiently studied.

Inhibition of synthesis of vazodilatiruyushchy prostaglandins or potentiation of vasopressor effect of adrenaline causes vasoconstrictive activity of GKS.

Indication

Atopic dermatitis (endogenous eczema, neurodermatitis), contact eczema, degenerative, disgidrotichesky, numulyarny eczema, nonspecific eczema, eczema at children.

Use

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Drug is applied 1 time a day with a thin layer on affected areas of skin, use of an occlusive bandage is possible. use duration usually should not exceed 12 weeks for adults and 4 weeks for children. within a year carrying out several courses of therapy is possible.

Can use medicament for treatment of acute inflammatory processes and the becoming wet eczema stages, at very oily skin and also at localization of processes both on smooth skin, and on skin with indumentum.

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Use of cream is contraindicated to

Contraindication

in a tuberculosis cutis, manifestations of syphilis on sites of putting drug; in viral infections (herpes simplex, chicken pox, shingles); manifestations of reaction to an inoculation; a rozatsea, circumoral dermatitis, hypersensitivity to Methylprednisolonum to an atseponat or any other component of drug.

Side effects

Hypersensitivity to Methylprednisolonum to an atseponat or any other component of drug; tubercular and syphilitic processes in the field of putting drug; viral diseases (for example chicken pox, shingles), a rozatsea, perioral dermatitis, ulcers, an acne, atrophic skin diseases, reactions after an inoculation in the field of putting drug.

Special instructions to

At infectious processes of skin which are caused by bacteria and/or mushrooms the additional corresponding antimicrobial therapy is necessary for

.

At Sterokort's use should avoid hit of medicament in eyes, on deep open wounds, on mucous membranes. If at the patient the glaucoma at the moment or in the anamnesis is revealed, he has to report about it it to the doctor.

It is known that at system therapy of GKS the glaucoma can also develop (for example after use in high doses or on a big surface during the long period, use of occlusive bandages or drawing on skin around eyes).

When drawing GKS for topical administration in high doses on the big areas of a body or during the long period, especially under an occlusive bandage, the risk of emergence of side effects considerably increases.

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When putting the medicament Sterokort on the big surface of skin (40–60% of a surface of skin) or even when using occlusive bandages neither at adults, nor at children did not reveal dysfunction of bark of adrenal glands. Despite this, when drawing on the big surface of skin duration of treatment has to be as less as possible long.

in case of the admission of the next use of Sterokort cream should not use the raised dose medicament at its following drawing.

If initial symptoms of a disease of skin appear after end of a course of treatment again, it is necessary to address to the doctor.

Period of pregnancy and feeding by a breast. There are no reliable data about use of the medicament Sterokort for pregnant women now.

Usually in Ι a trimester of pregnancy should avoid external use of the medicaments containing GKS (in particular the medicament Sterokort).

needs to consider a ratio risk/advantage when prescribing the medicament Sterokort to pregnant women.

during feeding by a breast should not apply Sterokort ointment on mammary glands. Especially it is necessary to avoid prolonged use of medicament or its drawing on big sites of skin.

Use in pediatrics. Separate cautions are not described.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Does not influence.

Interaction with other medicines is not described by

Interaction

.

Overdose

is not expected risk at excessive single use (putting medicament on the big area of skin) or inadvertent oral administration.

Storage conditions

At a temperature not above 25 °C.