Translation of the instruction Mose

HLORID-DARNITSA SODIUM solution for injections of 9 mg/ml

Instruction

On medical use of medicine

Ingredients:

Active ingredient: sodium chloride;

9 mg contain

1 ml of solution sodium of chloride;

excipient: water for injections.

Dosage form.

Solution for injections.

Main physical and chemical properties: the transparent colourless liquid salty on taste.

Pharmacotherapeutic group.

Blood substitutes and perfused solutions. solutions of electrolytes. atx code of the ó05th a03.

Pharmacological properties.

Pharmacodynamics.

0.9% solution of sodium of chloride normalizes water-salt balance and liquidates deficiency of liquid in a human body which develops at dehydration or owing to accumulation of extracellular liquid in the centers of extensive burns and injuries, at abdominal organs surgeries, peritonitis. Medicine improves perfusion of fabrics, increases efficiency of hemotransfusionic actions at massive blood losses and severe forms of shock. Renders also disintoxication effect as a result of short-term increase in volume of liquid, decrease in concentration of toxic products in blood, activation of a diuresis.

Pharmacokinetics.

by

it is Quickly brought out of the vascular system. Medicine is in a vascular bed short time then passes into interstitial and intracellular sectors. In 1 hour in vessels there is only about a half of the entered solution. Very quickly salts and liquid begin to be removed by kidneys, raising a diuresis.

Clinical characteristics.

Indication.

Preparation of solutions of medicines for external and parenteral use; locally for washing of wounds, a mucous membrane of a nose and also catheters and systems for transfusion.

Contraindication.

Incompatibility of the main medicine and solvent. not to apply medicine to washing of eyes at ophthalmologic operations.

Interaction with other medicines and other types of interactions.

chloride-darnitsa is compatible

Sodium to the majority of medicines therefore it can be applied to dissolution of various medicines — except for those medicines which are not compatible from sodium chloride as solvent.

Feature of application.

Before dissolution of medicine should be checked whether use of solution of sodium of chloride for dissolution of this medicine is possible.

Use during pregnancy or feeding by a breast.

Medicine can be applied during pregnancy or feeding by a breast.

Ability to influence but the speed of reactions at control of motor transport or other mechanisms.

does not influence.

Route of administration and doses.

Medicine to apply

as solvent to parenteral administration of the main medicine.

solution to apply

To washing of wounds, mucous membranes in enough.

Children.

Medicine children can apply

.

Overdose.

At the correct application it is improbable.

Side reactions.

are not observed by

at the correct use of medicine.

Expiration date.

5 years.

Storage conditions.

to Store

in original packing at a temperature not above 25 °C. not to freeze. to store out of children's reach.

Incompatibility.

Is defined

by medicine which should be dissolved with chloride sodium solution.

Packing.

On 5 ml in an ampoule; on 5 ampoules in blister strip packaging; on the 2nd blister strip packagings in a pack;

on 10 ml in an ampoule; on 5 ampoules in blister strip packaging; on the 2nd blister strip packagings in a pack.

Category of a holiday.

According to the prescription.

Producer.

Chao's

"pharmaceutical "darnitsa".

Location of the producer and its address of the place of implementation of activity.

Ukraine, 02093, of cues, st. Boryspil, 13.

HLORID-DARNITSA SODIUM solution for infusions of 9 mg/ml

Instruction

On medical use of medicine

Ingredients:

Active ingredient: sodium chloride;

9.0 mg contain

1 ml of solution sodium of chloride; ionic structure on 1 l of medicine: Na ⁺ – 154 mmol, Cl ^yu – 154 mmol;

excipient: water for injections.

Dosage form.

Solution for infusions.

Main physical and chemical properties: transparent colourless liquid.

Pharmacotherapeutic group.

Blood substitutes and perfused solutions. solutions of electrolytes. code atkh the ó05th a03.

Pharmacological properties.

Pharmacodynamics.

0.9% solution of sodium of chloride normalizes water-salt balance and liquidates deficiency of liquid in a human body which develops at dehydration or owing to accumulation of extracellular liquid in the centers of big burns and injuries, at abdominal organs surgeries, peritonitis.

0.9% solution of sodium of chloride improves perfusion of fabrics, increases efficiency of hemotransfusionic actions at massive blood losses and severe forms of shock.

also disintoxication effect as a result of short-term increase in volume of liquid, decrease in concentration of toxic products in blood Shows, activations of a diuresis.

Pharmacokinetics.

by

it is Quickly brought out of the vascular system. Medicine keeps in a vascular bed short time then passes into interstitial and intracellular sectors. In 1 hour in vessels there is only about a half of the entered solution. Very quickly salts and liquid begin to be removed by kidneys, raising a diuresis.

Clinical characteristics.

Indication.

For completion of deficiency of liquid in an organism and in a complex of actions of intensive care; as solvent for other compatible medicines. it can locally be applied to washing of wounds, a mucous membrane of a nose and also catheters and systems for transfusion.

Contraindication.

Overhydratation, a hyperchloremia, a hypernatremia, giperkhloremichesky acidosis, states connected with danger of edematization of lungs.

Medicine is not applied to washing of eyes at ophthalmologic operations.

Interaction with other medicines and other types of interactions.

0.9% solution of sodium of chloride it is compatible to the majority of medicines therefore it is applied to dissolution of various medicines, except for those medicines which are not compatible from sodium chloride as solvent.

Introduction of 0.9% of sodium of chloride can lead

to decrease in level of lithium.

Feature of application.

At long introduction, especially in large volumes, control the level of electrolytes in plasma and urine and also a diuresis.

is Carefully entered the patient with violation of secretory function of kidneys, with dekompensirovanny heart diseases, at a hydropic and ascitic syndrome at patients with cirrhosis.

Co-administration with corticosteroids or corticotropin demands constant control of level of electrolytes in blood.

Patients taking the lithium medicaments have to avoid too high or very low use of sodium. Monitoring of level of lithium in blood is recommended.

At shock states and blood losses along with use of solution of 0.9% of sodium of chloride can carry out a hemotransfusion, transfusion of plasma and plasma substitutes.

Use during pregnancy or feeding by a breast.

Medicine can be applied by

according to indications.

Ability to influence speed of response at control of motor transport or other mechanisms.

does not influence.

Route of administration and doses.

is Appointed intravenously, rektalno and outwardly.

is Entered intravenously by drop infusion to 3 l and more solution in day with a speed of 4-10 ml/kg/h, depending on a clinical situation and level of loss of liquid; apply orally; appoint 75–100 ml in enemas; apply to washing of wounds, mucous membranes.

Children.

to Children at shock dehydration (without definition of laboratory indicators) are entered by 20–30 ml/kg. further the mode of dosing is adjusted depending on laboratory indicators. the general daily dose depends on water and electrolytic balance, etc.

Overdose.

Can lead

to giperkhloremichesky acidosis, increase in removal of potassium from an organism, an overhydratation and a hypervolemia owing to what heart failure can develop. at emergence of symptoms of the specified states the introduction of medicine should be stopped, to estimate a condition of the patient and to render the adequate help.

Side reactions.

are not observed by

at the correct use of medicine.

When performing massive infusions the development of giperkhloremichesky acidosis is possible

.

Expiration date.

3 years.

Storage conditions.

to Store

in original packing at a temperature not above 25 °C. not to freeze.

to Store

out of children's reach.

Packing.

On 200 ml or on 400 ml in bottles.

Category of a holiday.

According to the prescription.

Producer.

Chao's

"pharmaceutical "darnitsa".

Location of the producer and address of the place of implementation of its activity.

Ukraine, 02093, of cues, st. Boryspil, 13.