tablets "Sildenafil 100 Ananta" are applied at treatment of disturbances of an erection which are defined as inability to reach and support the penis erection necessary for successful sexual intercourse.

Structure

(one tablet, coated, supports a sildenafil of citrate it is equivalent to a sildenafil of 100 mg).

Excipients: microcrystalline cellulose, calcium hydrophosphate anhydrous, sodium of a kroskarmelloz, magnesium stearate, Opadry II blue 31K80956 (lactoses monohydrate, a gipromelloz, the titan dioxide (E 171), triacetin, indigo carmine (E 132)), Opadry transparent 02K19253 (a gipromelloza, triacetin), the water purified.

Contraindication

• hypersensitivity to active agent or any of medicament excipients;
simultaneous use with donors of nitrogen oxide (such as amyle nitrite) or nitrates in any form is contraindicated to
• as it is known that sildenafit influences ways of metabolism of oxide of nitrogen / the cyclic guanozinmonofosfat (tsGMF) and exponentiates hypotensive effect of nitrates;
• simultaneous use of FDE-5 inhibitors (including sildenafit) with guanylate cyclase stimulators, such as riotsiguat, it is contraindicated as can lead to symptomatic hypotension;
• a state at which the sexual activity is not recommended (for example, heavy cardiovascular disorders, such as unstable stenocardia and heart failure of heavy degree);
• loss of sight on one eye owing to not arterial front ischemic neuropathy of an optic nerve irrespective of, is connected this pathology with the previous use of FDE-5 inhibitors or not;
• an abnormal liver function of heavy degree, arterial hypotension (arterial blood pressure is lower than 90/50 mm of a mercury column), recently had stroke or a myocardial infarction and the known hereditary degenerative diseases of a retina, such as pigmentary retinitis (a small amount of such patients has genetic disorders of FDE of a retina) as safety of a sildenafil was not investigated in such subgroups of patients.

Route of administration

Drug is used orally.

For effective effect of medicament needs sexual excitement.

Adult

Recommended dose makes 50 mg and is applied, in case of need, approximately for an hour before sexual intercourse. Depending on efficiency and tolerance of medicament it is possible to increase a dose to 100 mg or to lower to 25 mg. The maximum recommended dose makes 100 mg.

Maximum recommended frequency of use of medicament is 1 time a day. At use of medicament during meal the effect of medicament can come later, than at its use on an empty stomach.

Patients of advanced age

Need for dose adjustment at patients of advanced age is absent.

Patients with a renal failure

to Patients with a renal failure of easy and moderate degree (clearance of creatinine from 30 to 80 ml/minute) the recommended dose is similar to the dose stated above in the section "Adults".

, the recommended dose makes 25 mg. Depending on efficiency and tolerance of medicament it is possible to increase a dose to 50 mg and 100 mg.

As at patients with a liver failure (for example cirrhosis) the clearance of a sildenafil is reduced by

, the recommended dose makes 25 mg. Depending on efficiency and tolerance of medicament it is possible to increase a dose to 50 mg and 100 mg.

Patients who apply other medicines

Recommended initial dose of medicament to patients who apply CYP3A4 inhibitors except for a ritonavir whose use together with sildenafily is not recommended, is made by 25 mg.

for the purpose of minimization of risk of developing orthostatic hypotension a condition of the patients accepting blockers of alpha adrenoceptors needs to be stabilized prior to use of a sildenafil. The recommended initial dose of a sildenafil makes 25 mg.

Drug is not intended to

Feature of use

for use by women.

Children

by

for use by persons aged up to 18 years.

by

Drivers

Researches of influence of medicament on ability to run vehicles and to work with other mechanisms it was not carried out. As at use of a sildenafil it was reported about cases of dizziness and disturbances from organs of sight before taking the wheel of the vehicle or to work with mechanisms, patients need to find out what their individual reaction to medicament use.

Overdose

At use of a single dose of a sildenafil up to 800 mg the side reactions were similar to those which were observed at use of a sildenafil in lower doses, but met more often and were heavier. Use of a sildenafil in a dose of 200 mg did not lead to increase in efficiency, but caused growth of quantity of cases of development of side reactions (a headache, rushes of blood, to dizziness, dyspepsia, congestion of a nose, disturbances from organs of sight).

in case of overdose if it is necessary, resort to the ordinary supporting actions. Acceleration of clearance of a sildenafil at a hemodialysis is improbable owing to high extent of linking of medicament with proteins of blood plasma and lack of elimination sildenafit with urine.

Side effects

Most frequent side reactions were a headache, rushes of blood, dyspepsia, disorders of vision, congestion of a nose, dizziness and disturbance of perception of color.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 2 years.