Solution is applied to infusions of Sargin at the following indications:

• atherosclerosis of vessels of heart and brain;
• atherosclerosis of peripheral vessels, including with manifestations of the alternating lameness;
• diabetic angiopatiya;
• coronary heart disease;
• arterial hypertension;
• a state after the postponed acute disorder of cerebral circulation;
• myocardiopathy;
• chronic heart failure;
• hypercholesterolemia;
• stenocardia;
• chronic obstructive diseases of lungs;
• interstitial pneumonia;
• idiopathic pulmonary hypertensia;
• chronic post-embolic pulmonary hypertensia;
• acute and chronic hepatitises of various etiology;
• giperammoniyemiya;
• hypoxemic states;
• asthenic states in the course of a convalescence, including after infectious diseases and surgeries;
• metabolic alkalosis;
• depression of function of a thymus;
• arrest of development of a fruit and preeclampsia.

Structure

Active ingredient - L-arginini hydrochloridum (1 ml of solution contains L-arginine of a hydrochloride 42 mg).

Excipient - water for injections.

Contraindication

• hypersensitivity to drug;
• heavy renal failures, giperkhloremichesky acidosis;
• allergic reactions in the anamnesis;
• use of kaliysberegayushchy diuretics and also Spironolactonum;
• a myocardial infarction (including in the anamnesis).

Route of administration

Drug is administered intravenously by drop infusion with a speed of 10 thaws a minute within the first 10-15 minutes, then it is possible to increase rate of administering to 30 drops a minute.

Daily dose of medicament - 100 ml of solution.

At heavy disturbances of blood circulation in the central and peripheral vessels, at the expressed phenomena of intoxication, a hypoxia, asthenic states a dose of medicament it is possible to increase to 200 ml a day.

Maximum rate of administering of infusion solution should not exceed 20 mmol/hour

to Children to 12 years a dose of medicament is 5-10 ml on 1 kg of body weight a day.

For treatment of a metabolic alkalosis a dose needs to be calculated.

with a half of the calculated dose. Possible additional correction needs to be carried out after obtaining results of the updated acid-base balance.

Feature of use

Pregnant

Drug gets through a placenta therefore during pregnancy it can be applied only when the expected advantage for mother exceeds potential risk for a fruit.

Data on use of medicament during feeding by a breast are absent.

Children

use Drug to children of 3 years.

Drivers

during control of motor transport or works with other mechanisms should be careful as medicament can cause dizziness.

Overdose

Symptoms: renal failure, hypoglycemia, metabolic acidosis.

Treatment

in case of overdose infusion of medicament needs to be stopped. It is necessary to carry out monitoring of physiological reactions and maintenance of vital signs of an organism. If necessary enter alkalizing means and means for adjustment of a diuresis (saluretics), solutions of electrolytes (0.9% solution of sodium of chloride, 5% glucose solution). Symptomatic therapy.

Side effects

General disorders: the hyperthermia, feeling of heat, an ache are obese.

from a musculoskeletal system: joint pain.

from a digestive tract: dryness in a mouth, nausea, vomiting.

from skin and hypodermic cellulose: changes in the injection site, including hyperaemia, feeling of an itching, pallor of skin, up to a Crocq's disease.

from the immune system: reactions of hypersensitivity, including rash, urticaria, a Quincke's disease.

from a cardiovascular system: fluctuations of arterial blood pressure, change of a warm rhythm, pain in heart.

from nervous system: the headache, dizziness, sensation of fear, weakness, spasms, a tremor, is more often when speeding introduction.

Drug is incompatible

with thiopental.

Storage conditions

to Store

in original packing at a temperature not above 25 °C, out of children's reach. Not to freeze.

Expiration date - 2 years.