Structure and form of release

Active ingredients: Phenylephrinum, dimetinden maleate.

Structure

• 1 ml of medicine contains Phenylephrinum of 2.5 mg, dimetinden a maleate of 0.25 mg;
• additional substances: benzalkoniya chloride; lavender extract; sorbite (E 420); citric acid, monohydrate; sodium hydrophosphate, dodecahydrate; water for injections.

release Form

Spray nasal, solution.

Pharmacological properties

Rino's Eden - the combined medicine containing Phenylephrinum and dimetinden.

Rino's Eden reduces discharges from a nose and promotes clarification of the nasal courses, without breaking at the same time physiological functions of a ciliary epithelium and mucous membrane of a nose.

to sympathomimetic amines. Apply as nasal decongestant with moderate vasoconstrictive action, selectively stimulates α ₁ - adrenergic receptors of cavernous venous tissue of mucous membrane of a nose. Thus quickly and for a long time eliminates a rhinedema and its adnexal bosoms.

Dimetinden — the antagonist of histamine H ₁ - receptors, shows antiallergic action. It is effective at application in low doses, it is well transferred.

Rino's Eden is applied locally therefore his activity does not correlate with concentration of active agents in blood plasma.

At accidental oral administration the bioavailability of Phenylephrinum decreased and was about 38%, T _½ — about 2.5 h

System bioavailability of a dimetinden after oral administration in the form of solution is about 70%, T _½ — about 6 h

Indication

Symptomatic treatment at cold, congestions of a nose, sharp and chronic rhinitis; seasonal (hay fever) and nonseasonal allergic rhinitis, sharp and chronic sinusitis, vasomotorial rhinitis. auxiliary therapy at sharp average otitis.

Preparation for surgical intervention in a nose and elimination of a rhinedema and adnexal bosoms after surgical intervention.

Use

Before introduction of medicine should clean a nose carefully.

: on 1 injection in each nasal course 3–4 times a day.

should hold the Bottle vertically the spray up. Holding the head directly, to insert a tip into the nasal course, the short sharp movement to press the spray and, having extended it from a nose, to unclench. During injection it is recommended to inhale slightly through a nose.

7 days and depends on a course of the disease.

Contraindication

Hypersensitivity to any of medicine components.

Because of Phenylephrinum content this medicine, as well as other vasoconstrictors, is contraindicated at atrophic rhinitis and also to the patients accepting MAO inhibitors or accepting their last 14 days.

Usually medicine is well transferred by

.

mild temporary local reactions from a mucous membrane of a nose (sensation of burning or dryness) are In some cases possible

. Very seldom — development of allergic reactions (in particular local reactions from skin, an itch, the century, persons, the general weakness swelled).

Special instructions

should not apply Rino's Eden longer 1 week

As well as at use of other vasoconstrictors, it is not necessary to exceed the recommended medicine dose. Excessive use of medicine, especially at children and elderly people, can cause manifestations of systemic action of medicine.

with care medicine to patients with cardiovascular diseases, AG, closed-angle glaucoma, diseases of a thyroid gland.

Pregnancy and feeding by a breast

do not appoint Drug during pregnancy and feeding a breast.

Drivers

does not affect ability to influence speed of response at control of vehicles or work with other mechanisms.

Children

At children under 6 years do not apply medicine in this dosage form. It is necessary to apply other dosage form of medicine — Milt nasal drops.

Interaction

Drug is contraindicated to the patients applying Mao's inhibitors or accepting their last 14 days.

with care to the persons taking tricyclic antidepressants and the antihypertensive drugs, such as blockers of β-adrenoceptors.

Overdose

At accidental administration of medicament by small children inside it was not reported about any serious side effects.

Majority of cases were symptomless, was very seldom reported about feeling of fatigue, a stomach ache, mild tachycardia, increase in the ABP, excitability, insomnia, pallor of integuments.

Treatment: use of activated carbon, use of depletive for children of younger age is possible (gastric lavage is not required); to adults and children of advanced age appoint the use of a large amount of liquid.

Storage conditions

In original packing at a temperature not above 25 °C.