Pharmacological properties

Pharmacodynamics. rinazolin treats to group of local vasoconstrictors. oxymetazoline has sympathomimetic and vasoconstrictive effect, eliminating a rhinedema. narrows vessels in the site of application, reduces a rhinedema and the upper airways, reduces discharges from a nose. restores nasal breath. elimination of a rhinedema promotes restoration of aeration of adnexal bosoms, a tympanic cavity that prevents development of bacterial complications.

antiviral, anti-inflammatory, immunomodulatory and antioxidant action. Thanks to this combined action mechanism during conduct of clinical trials faster and effective elimination of symptoms of sharp rhinitis is proved (congestions of a nose, a rhinorrhea, sneezing, the worsened health).

Pharmacokinetics. At topical nasal administration in therapeutic concentration does not irritate a mucous membrane of a nose, does not cause hyperaemia. T _½ makes about 35 h after use of medicine. 2.1% of medicine are allocated with kidneys, about 1.1% are removed with a stake.

Duration of effect of medicine — up to 12 h

Indication

Acute rhinitis, allergic rhinitis, attacks of non-infectious vasomotorial rhinitis; for restoration of a drainage and nasal breath at diseases of adnexal bosoms of a nasal cavity, at an eustachitis at children aged till 1 year connected with rhinitis. for elimination of hypostasis before diagnostic manipulations in the nasal courses at children aged till 1 year.

Use

Just before use of medicine a bottle should be taken in a palm to warm up it to body temperature. before introduction of medicine it is necessary to clean a nose carefully. prior to application densely not to twist a cap! before the first use of medicine it is necessary to twirl a bottle cap for formation of an opening. after burying the cap should be twirled densely. a cap to unscrew, remove and, slightly pressing on the bottle body, to dig 1–2 drops of solution in a nose. during burying the head of the child has to be inclined back. it is necessary to hold the dosed bottle turned before the nasal course and to use medicament in each nasal course.

Rinazolin, drops nasal 0.01%, is intended for instillation in a nose.

on 1 drop of the medicine Rinazolin in each nasal course on 2–3 times a day.

to Children aged from 5 weeks till 1 year — 1–2 drops of the medicine Rinazolin in each nasal course 2–3 times a day.

should not apply the Single dose of the medicine Rinazolin more than 3 times a day and longer 5–7 days. It is not necessary to use medicament in doses, above recommended.

for application to babies and children aged till 1 year. For babies with insufficient body weight and premature babies the doctor has to define a necessary dose.

Children. To apply Rinazolin 0.01% to children from the birth till 1 year.

Contraindication

Hypersensitivity to medicine components. atrophic rhinitis. not to apply after transsphenoidal hypophysectomy or other surgical interventions with exposure of a meninx. at use of monoamine oxidase inhibitors (Mao) and during 2 weeks after the treatment termination by Mao's inhibitors and also other medicines promoting increase hell. with the increased intraocular pressure, especially at closed-angle glaucoma. at severe forms of cardiovascular diseases (for example ibs, ag). pheochromocytoma. metabolic violations (for example hyperthyroidism, diabetes). prostate hyperplasia. porphyria.

Side effects on the frequency of emergence classify

by such categories: very often (≥10%), it is frequent (≥1 and 10%), infrequently (≥0.1 and 1%), is rare (≥0.01 and 0.1%), is very rare (0.01%) and isolated cases.

from nervous system: very seldom — concern, insomnia, the increased fatigue (drowsiness, a sedation), a headache, hallucinations (especially at children).

from a cardiovascular system: seldom — palpitation, tachycardia, AG; very seldom – arrhythmia.

from a respiratory system: often — discomfort in a nose (for example burning) or xeromycteria, sneezing; infrequently — after the effect of use of the medicine Rinazolin will end — feeling of strong congestion of a nose, nasal bleeding; very seldom — an apnoea at babies and newborns.

from a musculoskeletal system: very seldom — spasms (especially at children).

from the immune system: infrequently — reactions of hypersensitivity (Quincke's disease, rash, an itch).

Special instructions

extra care at treatment of newborns and babies Is necessary for

. it was in rare instances reported about development of serious side reactions (in particular — an apnoea) in this age group after use of medicine in therapeutic doses. it is necessary to avoid exceeding the recommended dosages surely.

Should avoid prolonged use and overdose of medicine. Prolonged use of antiedematous for a nose can lead to weakening of effect of medicine. Abuse of this means can cause a mucosal atrophy and a reactive hyperemia with medicamentous rhinitis. Doses, above recommended, need to be applied only under observation of the doctor.

Existence as a part of medicine a chloride benzalkoniya in number of 18 mkg in one dose (4 drops: on 2 drops in each nasal course) can cause a bronchospasm.

Use during pregnancy or feeding by a breast

Pregnancy. During pregnancy and feeding by a breast to use medicament with extra care. Exceeding the recommended dosage is not allowed.

Feeding by a breast. Data on penetration of oxymetazoline into breast milk are unknown. Drug should be used during feeding by a breast in case of careful assessment of a ratio advantage/risk. During feeding by a breast it is not necessary to exceed the recommended dose as the overdose can reduce amount of breast milk at the woman.

Ability to influence speed of response at control of vehicles or work with other mechanisms. After prolonged use of medicine in the doses exceeding recommended it is impossible to exclude the general influence on a cardiovascular system. In such cases the ability to steer vehicles or to work with mechanisms can decrease.

Interaction

not to apply Mao's inhibitors and other medicines promoting increase hell because of risk of increase hell. the combined use of other vasoconstrictive medicines increases risk of development of side effects.

Overdose

After considerable overdose or accidental oral administration such symptoms can arise: a mydriasis, nausea, vomiting, cyanosis, fervescence, spasms, tachycardia, palpitation, arrhythmia, cardiovascular insufficiency, cardiac arrest, the increased sweating, agitation, spasms, ag, a fluid lungs, respiratory frustration, pallor, a miosis, a hyposmia, mental disorders.

besides, oppression of functions from central nervous system which is shown by drowsiness, decrease in body temperature, bradycardia, arterial hypotonia, an apnoea and possible development of a coma can arise.

Therapeutic measures at overdose: gastric lavage, intake of activated carbon, ventilation of the lungs. At decrease in the ABP to apply phentolamine. It is not necessary to accept angiotonic means. If necessary anticonvulsant therapy is shown.

Storage conditions

B the place protected from light at a temperature not above 25 °C.