PROPROTEN-100 INSTRUCTIONS FOR USE COMPOSITION active substance: 1 tablet contains antibodies to the brain-specific protein S-100 affinity purified C1000 - 3 mg excipients: lactose, microcrystalline cellulose, magnesium stearate. DOSAGE FORM Tablets. MAIN PHYSICAL AND CHEMICAL PROPERTIES: tablets of a flat-cylindrical shape, with a score and a chamfer, from white to almost white. On one flat side with a line there is the inscription MATERIA MEDICA, on the other flat side there is the inscription PROPROTEN 100. PHARMACOLOGICAL GROUP Homeopathic preparation. PHARMACOLOGICAL PROPERTIES Drugs used for alcohol dependence. Shows anti-alcohol effect, reduces alcohol cravings and reduces the likelihood of relapses. The drug reduces the manifestations of alcoholic "hangover" syndrome: psychopathological (agitation, mental stress, insomnia, irritability, anxiety, deterioration of mood, intense craving for alcohol) somatovegetative (weakness, sweating, headache, tremor, tachycardia, digestive disorders). The drug modifies the functional activity of the S-100 protein, which combines synaptic (informational) and metabolic processes in the brain. Sensitizing the neuronal membrane, modulates the synaptic plasticity of neurons. It has a modifying effect on the functional state of the brain structures involved in the formation of alcohol dependence: hypothalamus, hippocampus, etc. In alcohol dependence, it has a normalizing effect on the system of positive emotional support, which leads to a decrease in the frequency of self-stimulation of the lateral hypothalamus. Reduces burst activity of hippocampal neurons; reduces the number of circulating immune complexes in the peripheral blood, correlates with a decrease in ethanol consumption. It enhances the inhibitory effects of GABA (γ-aminobutyric acid) in the central nervous system. It has been experimentally established that the drug restores neurotransmitter balance and conditioned reflex activity. Increases the brains resistance to hypoxia and toxic effects. INDICATIONS Prevention and treatment of mild to moderate alcohol withdrawal symptoms. CONTRAINDICATIONS Hypersensitivity to drug components. INTERACTIONS WITH OTHER DRUGS AND OTHER KINDS OF INTERACTIONS No cases of interaction with other drugs have been identified. FEATURES OF APPLICATION The composition of the drug contains lactose, and therefore it is not recommended to prescribe it to patients with congenital galactosemia, glucose or galactose malabsorption syndrome, or with congenital lactase deficiency. APPLICATION DURING PREGNANCY OR BREASTFEEDING There are no data on the efficacy and safety of the drug during pregnancy and lactation, so it should not be prescribed during these periods. ABILITY TO INFLUENCE THE RATE OF REACTION WHEN DRIVING MOTOR VEHICLES OR OTHER MECHANISMS When using the drug, you should refrain from driving and working with potentially dangerous mechanisms. DOSAGE AND METHOD OF APPLICATION The drug is taken orally. Do not use with food. Take 1 tablet at a time. The tablet is kept in the mouth (preferably without chewing or swallowing) until it is completely dissolved. In the first 2:00 (in case of a hangover), take 1 tablet every 30 minutes in the next 8-10 hours - 1 tablet every hour. In case of sleep onset, the drug should be resumed after waking up. In the future, when the condition improves, the drug is prescribed 1 tablet every 2-3 hours (4-6 tablets per day) until the manifestations of alcohol withdrawal completely disappear. For severe alcohol withdrawal symptoms, therapy should be combined with drugs traditionally used for detoxification. To prevent relapses in order to reduce the pathological craving for alcohol, take 1-2 tablets per day for 2-3 months after accidental drinking, take an additional 2 tablets of the drug 2 times - in the afternoon and in the evening. CHILDREN There are no data on the efficacy and safety of the drug in children, so Proproten-100 should not be prescribed to patients of this age category OVERDOSE In case of an accidental overdose, dyspeptic symptoms are possible due to the components of the drug. ADVERSE REACTIONS Possible reactions of increased individual sensitivity to the components of the drug. Single short-term cases (5-10 minutes) of violation of accommodation ("double vision"). SHELF LIFE 3 years. Do not use after the expiration date indicated on the package. STORAGE CONDITIONS Store at a temperature not exceeding 25 ° C. Keep out of reach children place PACKAGING 20 tablets in a blister made of polyvinyl chloride film and aluminum foil 1 or 2 blisters with instructions for use in a cardboard box RELEASE CATEGORY Without prescription.

Manufacturer: Materia Medica (Russia)

Item Shape: Tablets

Registration certificate: UA / 3646/01/01

Materia Medica (Russia)