Proginorm Ovo capsules are used at the following indications:

• gynecologic:
  • violation, connected with deficiency of progesterone, namely: premenstrual syndrome, violation of a menstrual cycle (dizovulyation, anovulation), fibrous and cystous mastopathy, preklimakterichesky period;
  • replaceable hormonal therapy in a menopause (in combination with estrogenic therapy);
  • infertility at lyuteinovy insufficiency;
• obstetric:
  • prevention of a usual abortion or threat of an abortion against the background of lyuteinovy insufficiency;
  • threat of premature births.

Structure

Active ingredient - progesterone (one capsule soft contains progesterone 100 mg).

Excipients: peanut butter, soy lecithin; capsule cover: gelatin 150 Bloom, glycerin of 99%, titan dioxide (E171).

Contraindication

• hypersensitivity to medicine components;
• heavy abnormal liver functions;
suspect or is confirmed to
• a neoplasia of a breast or genitals;
• not diagnosed vaginal bleedings;
• unsuccessful or incomplete abortion;
• thrombophlebitis, romboembolichesky violations;
• cerebral hemorrhage;
• porphyria.

Route of administration

Is recommended to accept capsules, washing down with a glass of water on an empty stomach, it is desirable in the evening, before going to bed.

In most cases the average daily dose makes 200-300 mg in 1 or 2 receptions (200 mg in the evening, before going to bed, and 100 mg in the morning if there is such need).

At insufficiency of a lyuteinovy phase (a premenstrual syndrome, violations of a menstrual cycle, a premenopause, fibrous and cystous mastopathy): accept within 10 days (usually from the 17th to the 26th day of a cycle inclusive).

At replaceable hormonal therapy of a menopause: as separately the estrogenoterapiya is not recommended, progesterone it is necessary to apply as addition to it the last two weeks of each course which come behind one-week support of any replacement therapy during which cancellation bleeding can be observed.

At threat of premature births: accept 400 mg of the medicine "Proginorm Ovo" every 6-8 hours before disappearance of symptoms. The effective dose and frequency rate of application are selected individually depending on clinical manifestations of threat of premature births. After disappearance of symptoms a dose of the medicine "Proginorm Ovo" gradually reduce to supporting (for example 200 mg 3 times a day). In this dose medicament can be used up to 36 weeks of pregnancy.

Use of progesterone after the 36th week of pregnancy is not recommended to

.

to

Pregnant

to

Use of the capsules "Proginorm Ovo" is not contraindicated to

Feature of application

at pregnancy, including in the first weeks. During use of medicine any case of adverse effect of medicine on a fruit was not observed. At use of medicine in the second and third trimesters of pregnancy the control of function of a liver is necessary.

by

Intake of progesterone in breast milk in detail it was not studied. Therefore, its appointment should be avoided during feeding by a breast.

hypospadias given about possible development, at use of progestogens during pregnancy for prevention of a usual abortion, or threat of an abortion against the background of lyuteinovy insufficiency what the patient has to be informed on Exists.

Children Drug is not intended to

by

for application in pediatric practice.

Drivers

to Drivers of transport and operators of cars: the drowsiness and dizziness connected with administration of medicament internally are possible.

Use of capsules before going to bed allows to avoid these unpleasant consequences.

Overdose

Symptoms of overdose can be shown by symptomatology of side reactions, including drowsiness, dizziness, euphoria, a dysmenorrhea, reduction of duration of a cycle, a metrorrhagia.

usual dose can be

At some persons excessive through the existing or secondary emergence of unstable endogenous secretion of progesterone, hypersensitivity to medicament or very low accompanying oestradiol level in blood.

is enough

In such cases:

• to reduce a dose of progesterone or to appoint intake of progesterone in the evening before going to bed within 10 days for a cycle in case of drowsiness or fleeting dizziness;
• to transfer an initiation of treatment to later term in a cycle (for example, the 19th day instead of the 17th) in case of its reduction or blood discharges;
to check
• whether oestradiol level at the patient who receives the substituted hormonal therapy in a premenopauza is sufficient.

Side effects

Disorder of a reproductive system and mammary glands: frequent - change of periods, amenorrheas, the alternating bleedings; infrequent - a mastodynia.

Disturbance of the central nervous system: frequent - headaches; infrequent - drowsiness, short-term feeling of dizziness; very rare - a depression.

Gastrointestinal frustration: infrequent - vomiting, diarrhea, a lock; rare - nausea.

Gepatobiliarny frustration: infrequent - cholestatic jaundice.

Disturbance of the immune system: very rare - a small tortoiseshell.

Disease of leather and hypodermic cellulose: infrequent - an itch, an acne; very rare - a hloazma.

by

such manifestations of side reactions as change of a libido, discomfort in breasts, premenstrual symptoms, a hyperthermia, insomnia, an alopecia, a hirsutism, a venous thrombembolia, an embolism of a pulmonary artery, a liquid delay, change of weight, gastrointestinal frustration, anaphylactic reactions can be Also observed.

Drowsiness and/or dizziness are observed by

in case of the accompanying gipoestrogeniya. Reduction of a dose of medicine or increase in a dose of estrogen eliminates these phenomena at once, without reducing therapeutic effect.

If the course of treatment begins

very much early at the beginning of a monthly cycle, especially till 15th day, reduction of a cycle or accidental bleedings can take place.

Storage conditions

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 3 years.