Proginorm Gesta capsules are used at the following indications:

• decline in the ability to fertilization at primary or secondary infertility at partial or full lyuteinovy insufficiency (a dizovulyation, support of a lyuteinovy phase in preparation time to in vitro fertilization, the program of donation of ova);
• prevention of a usual abortion or threat of a spontaneous abortion at lyuteinovy insufficiency;
• prevention of premature births at women with a short neck of the uterus or at women with existence of premature spontaneous births in the anamnesis.

Structure

Active ingredient - progesterone (one capsule soft contains progesterone 200 mg).

Excipients: peanut butter, soy lecithin; capsule cover: gelatin 150 Bloom, glycerin of 99%, titan dioxide (E171).

Contraindication

• hypersensitivity to medicine components;
• heavy violations of functions of a liver;
suspect or is confirmed to
• a neoplasia of a breast or genitals;
• not diagnosed vaginal bleedings;
• unsuccessful or incomplete abortion;
• thrombophlebitis, thromboembolic violations;
• cerebral hemorrhage;
• porphyria.

Route of administration

Duration of treatment depends on the nature of a disease.

to enter

Capsule deeply into a vagina in a dorsal decubitus.

Before each use of medicine needs to wash up carefully hands that there is no detergent left on hands.

dose averages 200 mg of progesterone a day (one capsule on 200 mg, in 2 receptions, in the morning and in the evening which enter deeply into a vagina, if necessary by means of the applicator). The dose can be increased depending on reaction of the patient.

At partial insufficiency of a lyuteinovy phase (dizovulyation, violation of a menstrual cycle) the daily dose makes 200 mg within 10 days (usually from the 17th to the 26th day of a cycle).

At full insufficiency of a lyuteinovy phase (total absence of progesterone at women with the nefonktsioniruyushchy (absent) ovaries (donation of ova)): the dose of progesterone makes 100 mg for the thirteenth and fourteenth day of a cycle of transfer; from the 15th to the 25th day of a cycle the dose of progesterone makes 200 mg divided into two receptions (in the morning and in the evening); since 26th day, in case of early diagnostics of pregnancy, the dose increases, gradually (every week) by 100 mg of progesterone a day, reaching a maximum of 600 mg of progesterone a day divided into three receptions; it is necessary to adhere to this dosage till 60th day.

Support of a lyuteinovy phase during a cycle of in vitro fertilization: treatment is carried out, since evening of day of transfer of an embryo, from calculation for 600 mg a day to 3 receptions (200 mg once every 8 hours).

in case of threat of an abortion or for prevention usual vikidyshy because of lyuteinovy insufficiency: 200-400 mg a day (100-200 mg on one reception every 12 hours) up to 12 weeks of pregnancy.

Prevention of premature births at women with a short neck of the uterus or at women with existence of premature spontaneous births in the anamnesis the dose makes 200 mg a day and is applied in the evening before going to bed from the 22nd to the 36th week of pregnancy.

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Pregnant

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Use of the medicine "Proginorm Gesta" is not contraindicated to

Feature of application

at pregnancy.

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during use of medicine did not observe any case of adverse effect of medicine on a fruit. At use of medicine in the second and third trimesters of pregnancy the control of function of a liver is necessary.

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Intake of progesterone in breast milk in detail it was not studied. Therefore, its appointment should be avoided during feeding by a breast.

hypospadias given about possible development, at use of progestogens during pregnancy for prevention of a usual abortion, or threat of an abortion against the background of lyuteinovy insufficiency what the patient has to be informed on Exists.

Children Drug is not intended to

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for application in pediatric practice.

Drivers

"Proginorm Gesta" is not recommended to

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After reception control of vehicles and mechanisms.

Overdose

For today data on overdose of medicine are absent.

in case of overdose the application, symptomatic treatment and measures for support and control of vital signs is recommended to stop

.

usual dosage can be

For some patients superfluous as a result of continuous or new manifestation of unstable endogenous secretion of progesterone, or individual sensitivity to drug. In these cases it is appropriate to estimate need of reduction of a dose and/or change of rate of administration of medicament "Proginorm Gesta".

Side effects

Disorder of a reproductive system and mammary glands: frequent - change of periods, amenorrheas, the alternating bleedings; infrequent - a mastodynia.

Disturbance of the central nervous system: frequent - headaches; infrequent - drowsiness, short-term feeling of dizziness; very rare - a depression.

Gastrointestinal frustration: infrequent - vomiting, diarrhea, a lock; rare - nausea

Gepatobiliarny frustration: infrequent - cholestatic jaundice.

Disturbance of the immune system: very rare - a small tortoiseshell.

Disease of leather and hypodermic cellulose: infrequent - an itch, an acne; very rare - a hloazma.

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such manifestations of side reactions as change of a libido, discomfort in breasts, premenstrual symptoms, a hyperthermia, insomnia, an alopecia, a hirsutism, a venous thrombembolia, an embolism of a pulmonary artery, a liquid delay, change of weight, gastrointestinal frustration, anaphylactic reactions can be Also observed.

Drowsiness and/or dizziness are observed by

in case of the accompanying gipoestrogeniya. Reduction of a dose of medicine or increase in a dose of estrogen eliminates these phenomena at once, without reducing therapeutic effect.

If the course of treatment begins

very much early at the beginning of a monthly cycle, especially till 15th day, reductions of a cycle or accidental bleedings can take place.

reactions of hypersensitivity, including burning, the naggers, hyperaemia and also emergence of oily discharges Are possible

.

Storage conditions

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 3 years.