Pride solution for inf. 10mg/ml fl. 100 ml No. 1

A pride - analgetic and antipyretic for short-term treatment of a pain syndrome of average intensity, especially during the postoperative period, and short-term treatment of hyper thermal reactions when intravenous use is clinically proved or other routes of administration are unacceptable.

Structure

• active ingredient: paracetamol;
contains
• 1 ml of solution: paracetamol – 10.0 mg;
• other components: sorbitol (E 420), sodium hydrophosphate a dihydrate, sodium hydroxide, Acidum hydrochloricum diluted, water for injections.

Contraindication

Hypersensitivity to paracetamol, a hydrochloride propatsetamol (predecessor of paracetamol) or to other components of drug. Heavy hepatocellular insufficiency.

Side reactions

General disorders – an indisposition, reactions of hypersensitivity.

from heart – arterial hypotension.

from a gepatobiliarny system – growth of level of hepatic transaminases.

from the system of blood and lymphatic system – thrombocytopenia, a leukopenia, a neutropenia.

In clinical trials was reported about frequent side reactions at patients in the injection site (pain and burning).

Very seldom observed hypersensitivity reactions: from simple rash or a small tortoiseshell to an acute anaphylaxis that demanded the treatment termination.

was Also reported about cases of an erythema, reddening, an itching and tachycardia.

to Apply

intravenously.

For adults, teenagers and children with body weight more than 33 kg to use solution in bottles on 100 ml.

ATTENTION! In order to avoid errors of the dosage connected with discrepancy between milligrams (mg) and milliliters (ml) it is necessary to calculate carefully doses during the assigning and administration of the medicament PRAYD®, solution for infusions. Such discrepancy can cause accidental overdose and even a lethal consequence. At writing prescriptions it is necessary to specify the general dose in milligrams (mg) and the volume of the general dose in milliliters (ml).

Solution of paracetamol to apply

in the form of 15-minute infusion.

Feature of use

Use during pregnancy or feeding by a breast

in case of clinical need paracetamol can be applied during pregnancy, however only after careful assessment of a ratio advantage/risk. In this case it is necessary to observe strictly recommended dosage and duration of treatment.

After oral use in breast milk in small amounts. No side effects at children at use of paracetamol during feeding were noted by a breast. Therefore, medicine can be used during feeding by a breast.

by

for children with body weight more than 33 kg.

medicine not to apply

due to the lack of data on safety and efficiency to premature children.

Ability to influence speed of response at control of motor transport or other mechanisms

does not influence.

Overdose

Risk of damage of a liver (including lightning hepatitis, a liver failure, cholestatic hepatitis, cytolytic hepatitis) increases at elderly people, small children, patients with liver diseases, in alcoholism cases, in the presence of a nutritional dystrophy and at the persons accepting. In the specified cases the overdose can be lethal.

Symptoms appear within the first 24 hours and are shown by nausea, vomiting, anorexia, pallor, an abdominal pain.

in two days and reach a maximum in 4-6 days.

Urgent measures

• immediate hospitalization;
• definition of concentration of paracetamol in blood plasma as soon as possible after overdose prior to treatment;
• intravenous or oral administration of antidote, N-Acetylcysteinum (NAC) whenever possible not later than in 10 hours after overdose. NAC can be applied later, in 10 h after overdose, however treatment has to last longer;
• symptomatic treatment;
needs to carry out by
• before an initiation of treatment hepatic tests and to repeat each 24 hours;
• in most cases the level of hepatic transaminases return to normal of indicators in 1-2 weeks with complete recovery of function of a liver. In some cases transplantation of a liver can be required.

Interaction with other medicines and other types of interactions

Probenetsid twice reduces clearance of paracetamol by blocking of its linking with glucuronic acid therefore at combination therapy with probenetsidy the dose of paracetamol should be reduced.

Salicylates can increase elimination half-life of paracetamol from an organism.

Should be careful at combined use of medicine with inzimiruyushchy medicines (barbiturates, an isoniazid, carbamazepine, rifampicin, ethanol and others).

to minor changes of the international normalized relation (INR). In that case it is necessary to control MNO during treatment and within 1 week after completion of treatment of Prayd®.

At simultaneous use of paracetamol with flukloksatsilliny should be careful as the concomitant use was connected with a metabolic acidosis with the increased anion interval, especially at patients with risk factors.

to Store

at a temperature not over 25C.

to Store

out of children's reach.