Pikolaks cap. shouted. 0.75% fl. 30 ml

Pharmacological properties

Pharmacodynamics. sodium pikosulfat, active ingredient of medicament pikolaks, is depletive of local action of triarilmetanovy group. sodium pikosulfat after bacterial splitting stimulates her mucous membrane in a large intestine, accelerating a vermicular movement, promotes cumulation of water and electrolytes in a gleam of a large intestine. defecation stimulation, reduction of time of transit and softening a calla is result of it.

Pharmacokinetics. After oral administration of sodium pikosulfat reaches a large intestine without significant absorption. The active metabolite an encore - (p-hydroxyphenyl)-pyridyl-2-methane is formed after bacterial splitting in a large intestine, the beginning of action of Pikolaks usually occurs in 6–12 h after administration of drug, depending on release of an active metabolite. After oral administration the insignificant amount of medicine can be revealed in bodies and the systems of an organism.

Laxative effect of medicament does not correlate with the level of an active metabolite in blood plasma.

Indication

Constipations or states demanding defecation simplification.

Use

Tablet

is Appointed inside, it is desirable for the night.

appoint 5–10 mg of 1 times a day. At heavy and obstipation the adult about 15 mg once are recommended to accept.

to Children at the age of 4–10 years — 2.5-5 mg of 1 times a day.

For children effective single dose of medicament happens. If necessary the course of treatment at the child can be prolonged, but it is preferable to limit it for 3 days.

individually and usually should not exceed 10 days

Drop

Drug is dosed by means of the doser of the producer. Adult: 13–27 drops (5–10 mg of sodium of the pikosulfat); to children since 4 years (only on doctor's orders) — 7–13 drops (2.5-5 mg of sodium of the pikosulfat). Pikolaks it is necessary to accept for the night. After Pikolaks's use the bowel emptying happens in 10–12 h. Drug can be used both with liquid, and without it. Pikolaks it is not necessary to apply daily or throughout the long period without establishment of the cause of a constipation.

Contraindication

Hypersensitivity to medicament components; intestinal impassability; acute inflammatory bowel diseases and acute diseases of abdominal organs (including acute appendicitis, nonspecific ulcer colitis, peritonitis); abdominal pain, nausea and vomiting of unspecified origin; heavy dehydration.

in case of rare hereditary states as a result of which the hypersensitivity to medicament excipients (is possible see. Special INSTRUCTIONS), administration of medicament is contraindicated.

Pikolaks of a tablet — a state after GIT surgery.

Side effects

At short-term administration of medicament the side effects arise seldom. at long use of medicament in much the raised doses disturbances are possible:

from skin: skin rashes, urticaria, itching;

from water and electrolytic balance: loss of potassium, sodium and other electrolytes, development of dehydration is possible;

from digestive system: seldom — the dispeptic phenomena, nausea, vomiting, spasms and an abdominal pain, diarrhea, a meteorism, pain in a stomach and an anus, strengthening of motility of intestines which is taking place at a medicament dose decline;

from the immune system: allergic reactions, Quincke's disease;

from central nervous system: very seldom — a headache, increased fatigue, drowsiness, spasms, dizziness, a faint.

Pikolaks of a tablet

to Apply

with care at a hypopotassemia, the increased magnesium content in blood, to patients with the weakened organism.

Drug contains lactose that should be meant to patients with a hereditary lactose intolerance.

Use during pregnancy and feeding by a breast. Long experience did not reveal side undesirable or harmful effect of Pikolaks at inclusion in pregnancy time.

Proof concerning Pikolaks's penetration into breast milk are absent.

Despite this, Pikolaks it is possible to apply during pregnancy or feeding by a breast, only if, according to the doctor, the advantage of use of medicament exceeds potential risk for the fruit/child.

to apply

With extra care in the presence of threat of termination of pregnancy.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Patients have to mean that in connection with possibility of vazovagalny reaction (a spasm in a stomach), dizziness and/or a faint it is necessary to avoid potentially dangerous types of activity, such as control of motor transport or work with other mechanisms.

Children. Not to use medicament at children without consultation of the doctor. Not to apply a tablet on 7.5 mg at children aged up to 10 years. Not to apply a tablet on 5 mg at children under 4 years.

Pikolaks of a drop

to Patients with a chronic constipation should carry out by

full diagnostics and to establish the cause of a constipation.

Prolonged use of medicament can lead

to disturbance of water and electrolytic balance and a hypopotassemia.

was Reported about cases of dizziness and/or faint which coincided using pikosulfat sodium. The available information gives the chance to assume that the specified phenomena answer a faint (Valsalva connected with test) during the act of defecation, or are connected with the vazovagalny answer to an abdominal pain.

to Patients with rare hereditary intolerance of fructose should not take this medicament as it contains sorbite.

This medicine contains less than 1 mmol of sodium in 1 dose, that is is almost free from sodium.

Use during pregnancy and feeding grudyo. There are no sufficient researches of use of sodium of the pikosulfat with participation of pregnant women. Considering safety if it is possible, Pikolaks should not be applied during pregnancy.

Clinical data show that neither an active metabolite an encore - (p-hydroxyphenyl)-pyridyl-2-methane, nor its glucuronides do not get into breast milk. Thus, Pikolaks can be applied during feeding by a breast.

Researches on assessment of the impact on fertility were not conducted by

.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Researches of influence on ability to run vehicles and to work with other mechanisms were not conducted. However patients should be warned about a possibility of development owing to vazovagalny reaction (in particular an abdominal spasm) such side reactions as dizziness and/or a syncope. In case of an abdominal spasm the patient should avoid such potentially dangerous types of activity as control of motor transport or work with other mechanisms.

Children. To use medicament at children aged from 4 years only on doctor's orders.

Electrolytic imbalance can lead

Interaction

Overdose

Symptoms: reception of a pikolaks in high doses can cause diarrhea, intestinal colic and clinically significant disturbances of water and electrolytic balance (hypopotassemia, loss of other electrolytes and liquid). there are messages about ischemia of a mucous membrane of a large intestine at use of a pikolaks in higher doses, is much higher recommended in constipations. the long overdose leads to development of chronic diarrhea and an abdominal pain, hypopotassemia, secondary hyper aldosteronism, damage of kidneys and development of a nephrolithiasis, a metabolic alkalosis and muscle weakness as a result of a hypopotassemia are possible.

Treatment. Drug withdrawal, a vomiting call, gastric lavage, reception of enterosorbents (activated carbon), symptomatic treatment (correction of water and electrolytic balance, especially at patients of advanced age and children, use of spasmolysants).

Storage conditions

Tablet. in the place protected from light at a temperature not above 25 °C.

Drop. In original packing at a temperature not above 25 °C.