Pantozol – means for treatment of a round ulcer and a gastroesophageal reflux disease.

Indications

Adults and children of 12 years.

• Reflux esophagitis.

Adult.

• Eradikation Helicobacter pylori (H. pylori) at patients with H. pylori – the associated ulcers of stomach and duodenum in a combination with certain antibiotics.
• duodenum Ulcer.
• Stomach ulcer.
• Zollingera-Ellison's Syndrome and other hyper secretory morbid conditions.

Structure

• active ingredient: pantoprazole;
• 1 tablet contains pantoprazol sexivihydrat sodium of 45.1 mg in transfer on pantoprazol 40 mg;
• other components: krospovidon, calcium stearate, Opadri ІІ 85G68918 White (the polyvinyl alcohol which - is partially hydrolyzed the titan dioxide (E171), talc, makrogol/PEG, soy lecithin), sodium hydroxide, Opadri of the 9th titanium dioxide (E171), triethyl citrate, silicon dioxide colloidal anhydrous, hydrosodium carbonate, ferrous oxide yellow (E172), sodium lauryl sulfate), simetikon an emulsion (30%), a mannitol (E 421), sodium Carbon without.

Contraindication

Hypersensitivity to a pantoprazol, derivatives of benzimidazole or to medicament components.

Side reactions were observed by

about 5% of patients. The most frequent side reactions – diarrhea and headaches (about 1%).

Route of administration

Pantozol, the tablets covered with a kishechnorastvorimy cover it is necessary to accept in 1 hour prior to food entirely; not to chew and crush, wash down a tablet with water.

Adults and children of 12 years.

Treatment reflux esophagitis.

1 tablet of a pantozol a day. In some cases a dose it is possible to double (2 tablets Pantozola of 40 mg/days), especially in the absence of effect of use of other medicaments for treatment a reflux esophagitis.

For treatment 4 weeks. If it is not enough, treatment can be expected within the next 4 weeks.

Adult.

in combination with two antibiotics.

At adult patients with ulcer of stomach and duodenum and positive take on H. pylori needs to reach an eradikation of a microorganism by means of combination therapy. It is necessary to consider local data on bacterial resistance and national recommendations about use and prescribing of the appropriate antibacterial agents. Depending on sensitivity of microorganisms for an eradikation of H. pylori adult it is possible to appoint the following therapeutic combinations:

a) 1 tablet of a pantozol of 40 mg 2 times a day

+ 1000 mg of amoxicillin 2 times a day

+ 500 mg of a klaritromitsin 2 times a day

b) 1 tablet of a pantozol of 40 mg 2 times a day

+ 400-500 mg of metronidazole (or 500 mg of Tinidazolum) 2 times a day

+ 250-500 mg of a klaritromitsin 2 times a day;

c) 1 tablet of a pantozol of 40 mg 2 times a day

+ 1000 mg of amoxicillin 2 times a day

+ 400-500 mg of metronidazole (or 500 mg of Tinidazolum) 2 times a day.

Feature of use

Use during pregnancy or feeding by a breast

Pregnancy. Experience of use of medicament to pregnant women is limited. The potential risk for the person is unknown. Pantoprazol it is not necessary to apply during pregnancy, except need cases.

Feeding by a breast. There are data on excretion of a pantoprazol with breast milk of the person. The decision on the feeding termination by a breast or termination/abstention from medicament treatment is accepted by the doctor taking into account advantage of feeding by a breast for the child and advantage of treatment for the woman.

Pantozol is shown by

to children aged from 12 years for treatment a reflux esophagitis. Drug is not recommended to be used to children up to 12 years as data on safety and efficiency of medicament for this age category are limited.

Ability to influence speed of response at control of motor transport or other mechanisms

needs to take possible development of side reactions, such as dizziness and visual disturbances into account. In such cases it is not necessary to run motor transport or to work with other mechanisms.

overdose Symptoms at the person are unknown to

.

at in in introduction within 2 minutes were well transferred by

Dose up to 240 mg. As pantoprazol extensively contacts proteins of plasma, it does not belong to medicaments which can easily be removed by means of dialysis.

At overdose with the advent of clinical signs of intoxication perform symptomatic and maintenance therapy. There are no recommendations about specific therapy.

Interaction with other medicines and other types of interactions

Action of a pantoprazol on absorption of other medicines. Pantoprazol can reduce absorption of medicaments which bioavailability depends on pH of gastric juice (for example, some antifungal drugs, such as ketokonazol, itrakonazol, vnekonazol, or other drugs, such as erlotinib).

Drugs against HIV (atazanavir). Combined use of inhibitors of a proton pomp with atazanaviry and other medicaments against HIV which absorption depends on pH of gastric juice can lead to significant decrease in bioavailability of the last and affect their efficiency. Therefore combined use of inhibitors of a proton pomp with atazanaviry is not recommended.

to Store

at a temperature not over 30 With in original packing. To store out of children's reach.