Pharmacological properties

Pharmakodinamichesky parameters. gel of pantestin-darniyets supports two pharmaceutical active ingredient: dekspantenol and miramistin.

Dekspantenol — the irreplaceable component of normally functioning epithelium — is biologically active stable form of pantothenic acid.

Dekspantenol easily turns into pantothenic acid which increases the contents in cells of the restored glutathione (antioxidant effect), promotes ATP synthesis and also is a part of A (KoA) coenzyme. Molecules KoA and ATP are involved in synthesis of the fatty acids, phospholipids and cholesterol necessary for restoration of cellular membranes. Besides, KoA participates in reactions of metabolism of proteins of epithelial cells.

In the researches in vitro established influence of a dekspantenol on fibroblasts of the person — strengthening of their proliferation, processes of migration and adhesion, collagen synthesis.

Thanks to good penetration through skin and to high local concentrations dekspantenol it is widely applied to stimulation of processes of epithelization, granulation of the injured skin and reduction of a skin itch.

Besides, dekspantenol improves barrier properties, hydration of a corneal layer, reduces transepidermal loss of water, maintaining softness and elasticity of skin and also has anti-inflammatory properties.

for the purpose of prevention of infection it is long not healing wounds and treatments of a wound fever effect of medicine is complemented with an antiseptic agent miramistiny.

destructive effect on causative agents of a wound fever. Gram-positive cocci are highly sensitive to substance (first of all staphylococcus and also streptococci, including pneumococci). It is effective miramistin and concerning gram-negative activators. The activity of a miramistin is directed to microorganisms of both aerobic, and anaerobic type, the asporous and forming spores; including on microbic associations and hospital microflora with multiple resistance to antibiotics (increases sensitivity of microbes to the specified drugs). Education and growth of biofilms of Staphylococcus aureus and Streptococcus pyogenes (group A) brakes. Miramistin also effectively influences large viruses (including herpes), dermatophytes, ascomycetes, barmy and yeast-like mushrooms.

Thanks to the significant giperosmolyarny action in the field of a wound and adjacent fabrics application of a miramistin promotes slowing down of process of inflammation.

Local effects of a miramistin are complemented with stimulation of restoration of the damaged fabrics at its application, including in a case is long not healing wounds.

Pharmacokinetic parameters. At topical administration dekspantenol it is quickly absorbed, being metabolized in fabrics in pantothenic acid.

, substance has effect on microorganisms in the field of a wound and adjacent fabrics.

Indication

• Treatment and prevention of infection of insignificant grazes, burns, cuts and scratches; skin infections (including again infected neurodermatitis and eczema); wounds of various etiology and arrangement (including post-operating rooms, decubituses and trophic ulcers in a proliferative phase); sunblisters; treatment of the granulating burn wounds and preparation them to an autodermoplastika, improvement of engraftment of transplants of skin; parodont diseases (an ulitis — catarrhal or ulcer and necrotic forms; a periodontal disease — focal or widespread), diseases or traumatic damage of a mucous membrane of an oral cavity (stomatitis, including aphthous, chronic, recurrent); erosion of a neck of the uterus, erosive colpitis and injuries of a mucous membrane of a vagina; treatment and prevention of infection of an intertrigo and diaper dermatitis; prevention of radiation injuries of skin, mucous membranes, treatment of beam ulcers (in a proliferative phase).

Use

Locally. distribute a thin layer on a wound surface after its standard processing. later apply a sterile gauze bandage. as option — apply gel on a dressing material, and then on a wound surface.

in case of availability of wound exudate before use of gel a wound is processed an antiseptic agent and dried up a sterile napkin.

At damage of integuments and sunblisters medicine is applied on affected areas.

Gynecologic pathology: the tampons impregnated with medicine enter in a prone position deeply into a vagina.

In therapy of diseases of an oral cavity medicine is used only at adults. After clarification of an oral cavity, gel is distributed a thin layer on an affected area. During 1 h do not use liquid and food. At treatment of manifestations of prosthetic stomatitis it is possible to apply dentures after putting gel.

are Applied by 2–3 times a day within 7–10 days (before full healing of an affected area or decrease in intensity of inflammation).

Contraindication

Hypersensitivity to active pharmaceutical ingredients of medicine or other its components.

Side effects

• Reaction of hypersensitivity (as a rule, at individual intolerance rashes, hyperaemia of different degree of manifestation are noted a skin itch); seldom — short-term (the burning sensation disappears spontaneously during 15–20 c); dermatitis (contact or allergic), erythema, eczema, small tortoiseshell, irritation, hypostasis, dryness or moknuty skin.

Special instructions

to Protect eyes from gel hit.

in case of the expressed purulent exudation from a wound.

Duration of treatment is defined by the doctor individually.

(to avoid drawing on extensive sites of skin).

is Applied at children from the first days of life.

does not have impact on speed of response at control of vehicles or other mechanisms.

Interaction

Antimicrobial effect of a miramistin is inactivated:

• surfactants of anion type (soap solutions);
• other antiseptic agents.

Combined application of a miramistin:

• with antibiotics (system or local action) — is raised by sensitivity of microorganisms to them;
• with muscle relaxants of the depolarizing action — is raised by their efficiency;
• with muscle relaxants of not depolarizing action — is reduced by their efficiency.

Overdose

At topical administration. at accidental ingestion of gel carry out symptomatic treatment.

Storage conditions

At a temperature of ≤25 °C in original packing. not to subject to freezing.