Suppositories Ovestin appoint vaginal (candles) at the following indications:

• Hormonal Replacement Therapy (HRT) for treatment of the mucosal atrophy of lower parts of an urinogenital path connected with deficiency of estrogen at women in a postmenopause.
• Before - and postoperative treatment of women in a postmenopause at vaginal surgical interventions.
• As supportive application for diagnostics at doubtful cases of an atrophic picture of a cervical smear (Sha's class according to the Papanikolau test) at women in a postmenopause in case of identification of pathological cells which indicate an epithelium atrophy.

Structure

Active ingredient: estriol;

1 suppository contains estriol 0.5 mg;

Excipients: solid fat.

Contraindication

• It is established, cancer of mammary glands which is available in the anamnesis or suspected.
• malignant tumors Established or suspected an estrogenzavisimost (for example, endometrial cancer).
• Vaginal bleeding of not clear etiology.
• Not treated hyperplasia of endometrium.
• Previous or existing now venous thrombembolia (VTE) (deep vein thrombosis, an embolism of lungs).
• Established thromboembolic disturbances (for example, deficit of a protein With, a protein of S or antithrombin).
• Active or recently postponed thromboembolic diseases of arteries (for example, stenocardia, a myocardial infarction).
• Disease of a liver in an active form or liver diseases in the anamnesis after which indicators of function of a liver did not return to normal amounts.
• Hypersensitivity to active agent or to any of excipients.
• Porphyria.

Route of administration

Vaginal suppositories Ovestin should be entered into a vagina in the evening before going to bed. The patient has to enter a suppository in a prone position as it is possible more deeply in a vagina.

Feature of use

Pregnant women

during pregnancy.

Children

use Drug to children.

Drivers

does not influence.

Overdose

in case of introduction of a large amount of medicament at women and girls can appear nausea, vomiting and bleeding as a treatment withdrawal. Specific antidote is unknown. In case of need it is necessary to carry out symptomatic treatment.

Side effects

General disturbances and reactions in the injection site: irritation and an itching in the injection site, grippopodobny symptoms.

from genitals and mammary glands: discomfort and mammary gland pain, vaginal discharges.

Ritonavir and nelfinavir are known to

for powerful inhibitors, but they, on the contrary, show the inducing properties at use with steroid hormones.

Clinically significant increase in metabolism of estrogen and progestogens can lead

to decrease in efficiency of Ovestin and to change of a picture of bleeding.

Storage conditions

to Store

at a temperature of 2 ° - 25 °C in the dry, protected from light place.

to Store

out of children's reach.

Expiration date - 3 years.