Otofloks ear drops for treatment of otitises at dogs and cats the Dosage form and an upakovkasuspenziya for external use (ear drops) of yellowish color. About 10 ml in the plastic bottles with a dropper and the screw-on cover with a control corbel packed by the piece into cardboard boxes complete with the additional extended dropper with a cover and the instruction for application are packaged. Pharmacological (biological) properties and effects: Otofloks works protivoparazitarno, fungitsidno, antimicrobial; has anti-inflammatory and protivozudny properties. Pharmacological action of Otofloks is caused by properties of ivermectin, a klotrimazol, fluorfenikol and a beta metazone. Ivermectin belongs to group of the avermektin produced by microorganisms of the Streptomyces avermitilis group. Ivermectin at nematodes, ticks, insects and larvae of gadflies strengthens communication of GAMK (piperidic acid) with special receptors on the nervous terminations of a parasite, blocking that an innervation of a parasite, causing his paralysis and death. Ivermectin leads to death of the following types of ektoparazit: Otodectes, Haematopinus, Sarcoptes, Demodex, Gastrophilus, Hypoderma, Linognathus, Damalina, Solenopotes, Haematobia, Psoroptes, Oestrus, to Melophagus, etc. Klotrimazol belongs to imidazole derivatives. The effect of a klotrimazol is connected with violation of synthesis of the ergosterin which is a part of a cellular membrane of mushrooms. As a result, the structure and properties of membranes change, lysis of cages is observed. Dermatophytes, barmy mushrooms (sorts Candida, Torulopsis glabrata, Rhodotorula), mold mushrooms and also Pityriasis versicolor activators (multi-colored depriving) and eritrazma are sensitive to a klotrimazol. Besides, klotrimazol works antimicrobial for gram-positive (staphylococcus, streptococci) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis) and also to Trichomonas vaginalis, Malassezia furfur, Corynebacterium minussimum. Fluorfenikol is derivative a tiamfenikol in whom the hydroxyl group is replaced with fluor atom that causes its antibacterial activity against atsetiltransferazosinteziruyushchy bacteria. Fluorfenikol oppresses synthesis of proteins in cages of bacteria. In protoplasm it contacts 70S-ribosomal subunits, oppresses fermental activity of a peptidiltransferaza, reducing, thus, synthesis of proteins in ribosomes of the corresponding bacteria. Fluorfenikol affects bakteriostatichesk gram-positive and gram-negative bacteria, namely: Fusobacterium necrophorum, Bacteroides melaninogenicus, Streptococcus spp., Staphylococcus spp., Pasteurella spp., Salmonella spp., Proteus spp., Pseudomonas spp., Haemophilus spp. and also Mycoplasma spp., Rickettsia spp., Chlamydia spp. Beta metazones belongs to group of synthetic corticosteroids, possesses anti-inflammatory, protivozudny, antiallergic, anti-proliferative action. Sostav: 1 ml of medicine contains active ingredients: ivermectin - 1 mg; klotrimazol - 10 mg; fluorfenikol - 2.5 mg; beta metazones (in the form of dipropionate) - 1 mg. Excipients: dimethyl sulfoxide, ethanol, polyethyleneglycol, propylene glycol. Pokazaniya to application: Preparat is intended for treatment of small unproductive animals (dogs, cats and decorative rabbits) at the otitises of a different etiology including caused by ektoparazita and/or complicated by fungal or bacterial infections. Order of application and dosage: At treatment of animals at otitises the auricles and acoustical pass clean previously from ear sulfur, exudate and strup. Then 2 times a day dig in medicine, it is obligatory in each ear, in a dosage according to table 1 within 5-10 days depending on clinical manifestations. Animal weight Necessary quantity of drops (on one ear) up to 1 kg of 1 1 - 5 kg of 2 5 - 10 kg 3 10 - 15 kg 4 more than 15 kg 5 Protivopokazaniya to application: Ne to apply medicine the sick and exhausted animal; an animal in a lactation resort, to puppies, krolchata and kittens to 10 weeks age and also animal, sensitive to medicine components. Ne to apply ivermectin to sensitive breeds of dog (to a collie and their subspecies: sheltie, bobtails, etc.). Side effects: By-effects and complications at use of the medicine Otoksolan according to the present instruction, as a rule, are not observed. At some dogs at long reception the symptoms caused by influence of corticosteroid hormone can be observed (increase in level alkaline phosphotazy, aminotransferases, a neutrophilia, an eozinopeniye, a limfopeniye). In rare instances at old dogs the tranzitorny deafness can be observed. At the increased individual sensitivity of an animal to components of medicine and manifestation of allergic reactions (skin itch, the raised salivation) use of medicine is stopped. Measures of personal prevention: When performing treatment with use of medicine it is necessary to follow the general rules of personal hygiene and safety measures provided during the work with medicines. After use of medicine it is necessary to wash up hands with soap. People with hypersensibility to components of medicine should avoid direct contact with medicine. It is necessary to avoid contact with eyes. At accidental hit of medicine on skin or his mucous membranes it is necessary to wash away immediately a water jet, at hit inside - to see a doctor. At itself to have the instruction for application or the label. The empty package from under medicine is subject to utilization with household waste. Storage conditions: An expiration date - 2 years. After the first opening of a bottle – 28 days on condition of its storage in the dark place at a temperature from 5 ° up to 25 °C. Producer: BioTestLb, Ukraine Product code: 480521 - Otofloks ear drops for treatment of otitises at dogs and cats (10 ml) date editing the description: 16.01.2020