tablets "Normodipin" are applied at the following indications:

• arterial hypertension;
• chronic stable stenocardia;
• vasospastic stenocardia (Printsmetal's stenocardia).

Structure

Active ingredient - amlodipin (one tablet contains 5 mg of an amlodipin (in the form of 6.944 mg of an amlodipin of the bezilat)).

Excipients: magnesium stearate, sodium krakhmalglikolit (type A), calcium hydrophosphate anhydrous, cellulose microcrystalline.

Contraindication

Amlodipin is contraindicated to patients with the following states:

• hypersensitivity to an amlodipin, derivatives of dihydropyridine or to any other components of drug;
• heavy arterial hypotension;
• shock (including cardiogenic shock);
• obstruction of an output path of a left ventricle (for example, profound aortal stenosis);
• hemodynamically unstable heart failure after an acute myocardial infarction.

Route of administration

Adult

in case of a hypertension and stenocardia the initial dose makes 5 mg of 1 times a day. Depending on individual reaction of the patient to treatment this dose can be increased to the maximum 10 mg a day.

to the Patients having arterial hypertension, Normodipin is applied in a combination with thiazide diuretics, alpha blockers, beta-blockers or inhibitor of angiotensin-converting enzyme. To patients who have stenocardia and do not react to treatment by nitrates and/or adequate doses of beta-blockers, Normodipin it is possible to use as monotherapy or in combination with other anti-anginal means.

in case of co-administration of medicament with thiazide diuretics, beta-blockers and APF inhibitors.

Children and teenagers aged from 6 up to 17 years having arterial hypertension

Recommended initial dose for treatment of arterial hypertension at patients aged from 6 up to 17 years makes 2.5 mg a day (in this case it is necessary to use other drug) if after 4 weeks of use of medicament the control over arterial blood pressure is not reached, it is possible to increase a dose to 5 mg a day. Use of the doses exceeding 5 mg a day for treatment of patients of children's age were not studied.

Safety of use of an amlodipin for treatment of pregnant women is not established to

Feature of use

. Use during pregnancy is recommended only in case of lack of a safe alternative or if the disease of mother constitutes big danger to mother and a fruit, than treatment.

Amlodipin gets into breast milk. The share from the maternal dose received by the baby was estimated with an interquarter range of 3-7%, at most 15%. Influence of an amlodipin on babies is unknown. The decision on the extension/termination of breastfeeding or on the treatment extension/termination amlodipiny should be accepted taking into account advantage of breastfeeding for the child and the advantage received by mother from treatment.

to

It was reported that at some patients receiving blockers of "slow" calcium channels reverse biochemical changes in heads of spermatozoa were observed. Clinical data on potential impact of an amlodipin on fertility are limited.

Drivers

Amlodipin can affect ability to drive the car or other mechanisms to some extent. If at the patient who accepts amlodipin, dizziness, a headache, increased fatigue or nausea is noted, they can affect the speed and quality of reactions. It is recommended to be careful at the initial stage of treatment.

Overdose

Symptoms

Available data demonstrate that the considerable overdose can lead to an excessive peripheral vazodilatation with development of reflex tachycardia. Cases of the profound and persistent arterial hypotension, including with development of shock and a lethal outcome are described.

Treatment

Clinically significant hypotension caused by overdose of an amlodipin demands holding the active actions directed to maintenance of function of a cardiovascular system, including reduction of the lower extremities in the raised situation, monitoring of indicators of cardiac performance and lungs, control of volume of the circulating blood and a diuresis.

. For elimination of consequences of blockade of calcium channels intravenously to enter a calcium gluconate.

In certain cases effective. Prescribing of activated carbon to healthy volunteers in a dose of 10 mg at once or within 2 hours after reception of an amlodipin led to considerable decrease in absorption of drug. As amlodipin substantially contacts proteins of blood plasma, the hemodialysis is ineffective.

Side effects

such undesirable reactions: drowsiness, dizziness, headache, tachycardia, inflows, abdominal pain, nausea, hypostasis of shins, hypostases and fatigue.

to Store

in original packing for protection against influence of light at a temperature not above 30 °C, out of children's reach.

Expiration date - 3 years.