Structure and form of release

Structure

Active ingredient: nifuroxazid; 5 ml of suspension support a nifuroksazid of 200 mg;

excipients: sucrose, carbomer, citric acid, sodium hydroxide, methylparaben (E 218), food flavor (banana), ethanol of 96%, the water purified.

Ethanol content in 1 ml of suspension makes 2%.

release Form

Suspension oral.

Pharmacological properties

Nifuroksazid — an intestinal antiseptic agent, derivative 5 nitrofurans; it is active concerning the majority of causative agents of intestinal infections (including the strains mutants resistant to other antimicrobial means): gram-positive (family of staphylococcus) and gram-negative (family of enterobacteriaceae: escherichia, citrobacter, enterobacter, klebsiella, salmonella, shigella, proteus, yersinia) and also vibrio cholerae. it is not active concerning bacteria of the sort pseudomonas and the sort proteus (type of proteus inconstans) and also strains of subgroup of an of a look providentia alcalifaciens.

It is supposed p that medicament brakes activity of dehydrogenases and breaks protein synthesis in pathogenic bacteriums. In so-so therapeutic doses renders bacteriostatic activity, and in higher — bactericidal action. The effect is shown from the first hours of treatment. In therapeutic doses practically does not break balance of intestinal microflora; does not give development of resistant strains of pathogenic microorganisms and cross resistance of bacteria to other antimicrobial means that allows to appoint, if necessary, in generalizirovanny infections it in complex therapy with system drugs. In intestinal infections of virus genesis interferes with development of bacterial superinfection.

Pharmacokinetics. After reception it is practically not soaked up from digestive tract, creating high concentration of active ingredient in intestines. Thanks to such pharmacokinetic features, medicament has exclusively enteral antiseptic action, has no system antibacterial activity, does not cause the cumulative toxic effects; it is brought out of an organism with a stake. Drug does not influence clinical and biochemical indicators of blood.

Indication

Acute diarrhea of an infectious etiology.

Contraindication

Hypersensitivity to a nifuroksazid, other derivatives 5 nitrofurans or to other components of drug.

Route of administration and doses

Nifuroksazid should be applied inside, irrespective of meal, at regular intervals. Before use suspension needs to be shaken up. The maximum daily dose - 800 mg (20 ml).

Children aged from 2 years: on 5 ml of suspension 3 times a day.

Adult: on 5 ml of suspension 4 times a day.

treatment Duration - no more than 7 days

Children. Not to apply to children up to 2 years.

Feature of use

At treatment of acute diarrhea rehydration therapy (orally or parenterally, depending on a condition of the patient). It is not necessary to be limited to use only nifuroksazidy at treatment of the diarrhea complicated by sepsis as medicament is not soaked up in intestines and does not come to a blood stream. During treatment nifuroksazidy it is contraindicated to take alcohol (possibly development of disulfiramopodobny reaction (dermahemia, feeling of heat, sonitus, the complicated breath, tachycardia, sensation of fear)). nifuroksazid contains sucrose that should be considered when prescribing medicament sick diabetes. Before prescribing of suspension the babies need to exclude deficiency of enzymes which split sucrose.

Use during pregnancy or feeding by a breast

Is not present data on adverse influence on a fruit at use of a nifuroksazid during pregnancy, but whenever possible it is necessary to avoid its use. If necessary, under observation of the doctor, the women nursing can appoint drug.

to Drivers

does not influence.

Nifuroksazid is not recommended to apply

along with sorbents and also with medicaments which part ethanol is.

Side reactions

it is rare — an abdominal pain, nausea, strengthening of diarrhea. These symptoms do not demand the treatment termination. The individual hypersensitivity to medicament (short wind, skin rashes, an itching) which demands medicament withdrawal and performing symptomatic therapy is in rare instances possible.

Cases of overdose are not described by

. In case of overdose the gastric lavage and symptomatic treatment is recommended.

Storage conditions

to Store

in protected from light and the place, inaccessible for children, at a temperature not above 25 °C. An expiration date - 2 years.