Effect of medicament is caused by effect of its active components.

Neurotropic vitamins of group B make favorable impact on inflammatory and degenerative diseases of nerves and the motive device. Are applied to elimination of scarce states, and in high doses they have analgeziruyushchy effect, improve blood circulation, normalize work of nervous system and process of a hemopoiesis.

Vitamin B 1 (thiamine) is very important active agent. In an organism vitamin 1 is phosphorylated with education biologically active the tiamindifosfat (cocarboxylase) and the tiamintrifosfat (TTR).

Tiamindifosfat as coenzyme takes part in process of carbohydrate metabolism which are crucial in exchange processes of nervous tissue, influence carrying out a nervous impulse in synapses. At insufficiency of vitamin B 1 in fabrics there is an accumulation of metabolites, first of all lactic and pyruvic acid that leads to various morbid conditions and disorders of activity of nervous system.

Vitamin B 6 (pyridoxine) in a fosforilirovanny form (piridoksal-5-phosphate, PALP) is coenzyme of a number of the enzymes interacting in the general not oxidizing metabolism of amino acids. Through decarboxylation they participate in formation of physiologically active amines (adrenaline, a histamine, serotonin, a dopamine, tyramine), through transaminations - before anabolic and catabolic processes of exchange (for example, a glutamate-oksaloatsetattransaminaza, a glutamatpiruvattransaminaza, γ-aminobutyric acid, an exchange processes) and also to various processes of splitting and synthesis of amino acids. Vitamin B 6 affects 4 different metabolisms of tryptophane. In the course of hemoglobin synthesis vitamin B 6 catalyzes formation of a-amino-b-ketoadipic acid.

Vitamin B 12 (cyanocobalamine) is necessary for

for processes of cellular metabolism. He influences hemopoiesis function (external antianemic factor), participates in formation of sincaline, methionine, creatinine, nucleic acids, possesses the anesthetizing action.

Pharmacokinetics. After parenteral administration, thiamine is distributed in an organism. About 1 mg of thiamine breaks up daily. Metabolites are removed with urine. Dephosphorylation happens in kidneys. The biological half-life period of thiamine is 0.35 hours. Accumulation of thiamine in an organism does not happen thanks to limited dissolution in fats.

Vitamin B 6 is phosphorylated and oxidized to piridoksal-5-phosphate. In blood plasma piridoksal 5 phosphate and piridoksal contact albumine. To a form, is transported, is piridoksal. For passing through a cellular membrane the piridoksal-5-phosphate connected with albumine is hydrolyzed by alkaline phosphatase in piridoksal.

Vitamin B 12 after parenteral administration forms transport proteinaceous complexes which are quickly absorbed by a liver, marrow and other proliferative bodies. Vitamin B 12 comes to bile and takes part in enterohepatic circulation. Vitamin B 12 passes through a placenta.

Indication

Neurologic diseases of various origin: neuritis, neuralgia, polyneuropathy (diabetic, alcoholic), radicular syndrome, retrobulbarny neuritis, damage of a facial nerve.

Contraindication

Hypersensitivity to medicament components an acute disorder of warm conductivity acute form of dekompensirovanny heart failure.

Vitamin B 1 is contraindicated to

at allergic reactions. Vitamin B 6 it is contraindicated to p to apply

in a peptic ulcer of a stomach and duodenum in an aggravation stage (as increase in acidity of gastric juice is possible). Vitamin B 12 it is contraindicated to p to apply

in an erythremia, a hyperglobulia, a thrombembolia.

Lidokain. Hypersensitivity to lidocaine or to others of amide mestnoanesteziruyushchy means, existence in the anamnesis of epileptiform spasms on lidocaine, heavy bradycardia, heavy arterial hypotension, cardiogenic shock, severe forms of chronic heart failure (II-III degrees), a sick sinus syndrome, Wolf's syndrome - Parkinson-Whyte, Adams-Stokes's syndrome, AV (AV) blockade of II and III degree, a hypovolemia, heavy abnormal liver functions / kidneys, a porphyria, a myasthenia.

Route of administration and doses

For introduction.

conducting skin test on the increased individual sensitivity to medicament which hypostasis and reddening of the place of an injection demonstrates is obligatory for

Before use of the medicine containing lidocaine.

treatment to begin with

In hard (sharp) cases with 2 ml of solution intramusculary 1 time a day before removal of acute symptoms. For continuation of treatment to appoint 2 ml (1 injection) 2-3 times a week. The course of treatment lasts not less than 1 month.

Injection should be carried out in an upper external quadrant of a gluteus.

or continuation of a therapeutic course of injections or for prevention of a recurrence is recommended to

For maintenance the medicament Neuromax., tablets, film coated.

Overdose

Vitamin B 1 has wide therapeutic range. Very high doses (more than 10 g) show kurarepodobny effect, suppressing conductivity of nervous impulses.

Vitamin B 6 has very much hypotoxicity.

Excessive use of vitamin 6 more than 1 g a day within several months can give

in doses to neurotoxic effects.

Neuropathy with an ataxy and sensitivity disorders, cerebral spasms with changes on EEG and also in some cases hypochromia anemia and seborrheal dermatitis were described after introduction more than 2 g a day.

Vitamin B 12: after parenteral administration (in rare instances - after oral administration) doses of medicament high, than recommended, allergic reactions, eczematic skin disturbances and a benign form of an acne were observed.

At prolonged use in high doses the disturbance of activity of enzymes of a liver, pain in heart, hypercoagulation is possible

.

Treatment: symptomatic therapy.

Lidokain. Symptoms: psychomotor excitement, dizziness, the general weakness, a lowering of arterial pressure, a tremor, a disorder of vision, toniko-clonic spasms, a coma, collapse, AV blockade, oppression of central nervous system, an apnoea is possible. The first symptoms of overdose at healthy people arise at concentration of lidocaine in blood more than 0.006 mg/kg, spasms - at 0.01 mg/kg.

Treatment: the termination of administration of drug, oxygenotherapy, anticonvulsants, vasoconstrictors (noradrenaline, a phenylephine hydrochloride), in bradycardia - cholinolytics (0.5-1 mg of atropine). Carrying out an intubation, artificial ventilation of the lungs, resuscitation actions is possible. Dialysis is inefficient.

Structure

active ingredients: 1 ml of a pyridoxine of a hydrochloride of 50 mg, thiamine of a hydrochloride of 50 mg, cyanocobalamine of 0.5 mg

excipients: lidocaine a hydrochloride, potassium hexacyanoferrate, sodium polyphosphate, benzyl alcohol, sodium hydroxide, water for injections.

Storage conditions

to Store

in original packing at a temperature from 2 ° to 8 °C.

to Store

out of children's reach.

Expiration date - 2 years.