Natubiotin - vimtaminny medicament for treatment and prevention of the diseases caused by deficiency of biotin: diseases of skin, nails, hair.

Treatment of genetically caused enzymopathies associated with biotin (multiple insufficiency a carboxymanhole).

Structure

• active ingredient: biotin;
• 1 tablet contains 5 mg of biotin;
• excipients: microcrystalline cellulose; lactose, monohydrate; K30 povidone; krospovidon; magnesium stearate.

Contraindication

Hypersensitivity to biotin or to other components of drug.

Special security measures.

Squirrels of crude egg avidin which interacts with biotin therefore it is necessary to avoid their concomitant use contains a protein.

Use of a large number of crude eggs for 2-3 weeks can cause deficiency of biotin.

Drug contains lactose therefore to patients with rare hereditary forms of intolerance of a galactose, insufficiency of lactase or a syndrome of glyukozo-galaktozny malabsorption it is not necessary to use drug.

Route of administration

Recommended dose the adult at treatment of deficiency of biotin (diseases of nails, hair, skins) – 1 tablet on 5 mg a day.

For treatment of genetically caused enzymopathies associated with biotin (multiple insufficiency a carboxymanhole), are appointed by 1-2 tablets (a daily dose - to 20 mg of biotin).

to take the Pill to food, without chewing, washing down with enough liquid.

Duration of a course of treatment depends on character and a course of the disease.

Feature of use

Influence on clinical laboratory tests.

Depending on a research, results can be false high or in a false manner low owing to intake of the medicine containing biotin. The risk of influence is higher at children and patients with a renal failure and increases at higher doses.

At interpretation of results of laboratory researches needs to consider potential impact of biotin, especially if the lack of consistency with a clinical picture is observed (for example, the results of testing of a thyroid gland imitating Greyvs's disease at the asymptomatic patients accepting biotin or false-negative results of a research of a troponin at patients with a myocardial infarction which accept biotin). When there is a suspicion on influence, the alternative tests irresponsive to biotin influence have to be used.

At the order of laboratory tests to the patients accepting biotin should consult with personnel of laboratory.

Use during pregnancy or feeding by a breast

According to the standard principles, it is possible to apply Natubiotin at pregnancy or during feeding by a breast only when the expected advantage for the woman exceeds potential risk for the fruit/child.

information of rather negative impact of medicament at pregnancy and during feeding by a breast. Biotin gets through a placenta and gets to breast milk. Breast milk usually contains 7-13 mkg of biotin/l.

Children

Due to the limited experience of use do not use medicament to children up to 12 years.

to Children from 12 years medicament is used on doctor's orders; recommendations about a dosage of medicament are absent because of limitation of the relevant data.

Ability to influence speed of response at control of motor transport or other mechanisms

does not influence.

Overdose

is not present messages concerning biotin overdose For today.

Side reactions

from the immune system: very seldom (˂ 1/10000) allergic reactions, including a small tortoiseshell.

and to see a doctor.

Interaction with other medicines and other types of interactions

At use of biotin with anticonvulsant medicaments decrease in concentration of biotin in blood plasma due to its increased removal with urine. Valproic acid reduces activity of biotinidase, reducing functions of mitochondrions in a liver.

Pantothenic acid in high doses competes with biotin therefore it is necessary to avoid their concomitant use.

to Store

in original packing at a temperature not above 25 °C out of children's reach.