Pharmacological properties

Pharmacodynamics. xylomethazolinum is a sympathomimetic agent (imidazole derivatives) operating on α-adrenergic receptors of a mucous membrane of a nose. after nasal introduction xylomethazolinum causes narrowing of blood vessels, thereby reducing hypostasis of a mucous membrane of a nasopharynx.

within 2 min. after application and remains up to 12 h

Drug well is transferred, including patients with a sensitive mucous membrane. Drug reduces mukotsiliarny function. Results of laboratory researches showed that xylomethazolinum reduces infectious activity of a rhinovirus of the person which is associated with a common SARS.

Pharmacokinetics. After nasal introduction the amount of the absorbed substance can sometimes be sufficient for receiving system influence, for example, on central nervous system and a cardiovascular system.

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Indication

Symptomatic treatments of congestion of a nose at cold, hay fever, sinusitis, allergic rhinitises;

• for simplification of outflow of a secret from adnexal bosoms of a nose;
• as auxiliary therapy at average otitis for elimination of hypostasis of a mucous membrane of a nasopharynx;
• for simplification of carrying out a rinoskopiya.

Use

Multigrip nazal, drops nasal, solution of 0.05%. children at the age of 2–12 years. the recommended dose makes 1–2 drops 1–2 times a day in each nasal course.

Multigrip Nazal, drops nasal, solution of 0.1%. Adults and children are aged more senior than 12 years. The recommended dose makes 2–3 drops 2–3 times a day in each nasal course.

in the doses exceeding recommended.

application Duration. It is not necessary to use medicament more than 5 days in a row if another is not recommended the doctor.

Before further use of xylomethazolinum should take a break for several days between receptions.

Multigrip Nazal, spray nasal, solution of 0.05%. Children aged from 2 up to 12 years. On 1 injection in each nasal course in case of need, but no more than 3 times a day.

Multigrip Nazal, spray nasal, solution of 0.1%. Adults and children are aged more senior than 12 years. The recommended dose makes on 1 injection in each nasal course 3 times a day.

in the doses exceeding recommended.

application Duration. Multigrip Nazal it is not necessary to apply more than 5 days in a row if other is not recommended the doctor.

Route of administration. Before application to remove a protective cover. Before the first application it is necessary to press 2–3 times the portioning device to reach a correct dose of injection. Thus, spray is ready to application.

Before use of nasal spray should clean a nasal cavity carefully. It is recommended to apply the last dose in day before going to bed.

After removal of a protective cover an opening of the doser needs to be entered into the nasal course and to press once for easy breath through a nose.

At application the bottle has to be in vertical position. It is not necessary to use a bottle in horizontal position.

After application to close a protective cover.

Contraindication

Hypersensitivity to active ingredient or any excipient;

• dry rhinitis (when inflammation of a mucous membrane of a nose is not followed by secretion);
• glaucoma;
• transfenoidalny hypophysectomy or surgical interventions with exposure of a firm meninx.

Multigrip Nazal, drops and spray nasal, solution of 0.05%:

• children under 2 years;

Multigrip Nazal, drops and spray nasal, solution of 0.1%:

• children age up to 12 years.

Side effects

from the immune system: very seldom (1/10,000) — reactions of hypersensitivity, including a Quincke's disease, rash, the naggers.

from nervous system: often (≥1/100–1/10) — a headache.

from an organ of sight: very seldom (1/10,000) — tranzitorny deterioration in sight.

from heart: very seldom (1/10,000) — violation of a rhythm or tachycardia.

from respiratory organs, a thorax and mediastinum: often (≥1/100–1/10) — dryness or discomfort from a mucous membrane of a nose, burning sensation.

from a GIT: often (≥1/100–1/10) — nausea.

General violations and reactions in the injection site of medicine: often (≥1/100–1/10) — burning in the site of application.

Special instructions

As well as other sympathomimetics, xylomethazolinum should be applied with care at patients who at use of adrenergic medicines have side reactions which are shown insomnia, dizziness, a tremor, arrhythmias or increase hell.

Patients who need continuous treatment by xylomethazolinum can use this medicament longer period only under fixed clinical observation as there is a risk of a mucosal atrophy of a nose.

in case of repeated use of xylomethazolinum the risk of emergence of a tachyphylaxis and iatrogenic rhinitis exists.

Repeated and/or long instillations can cause system absorption of xylomethazolinum in the quantities causing system side reactions.

Xylomethazolinum should be applied with care and only if the therapeutic effect exceeds potential risk at the patients accepting MAO inhibitors, antidepressants or other medicines which can raise the ABP, patients with a serious cardiovascular illness (such as coronary artery diseases, AG), a pheochromocytoma, disbolism (for example a hyperthyroidism, diabetes, a porphyria).

to a reactive hyperemia of a mucous membrane of a nose, especially after long-term treatment or at application of high doses. Repeated or constant use of this medicine can lead to a kongestivny withdrawal and narrowing of the upper airways. It can be shown by chronic hyperaemia of a mucous membrane of a nose (that can lead further to atrophic rhinitis). In cases of moderate severity the use of medicine in one of the nasal courses can be suspended or as an alternative, not to be entered into both nasal courses before decrease in intensity of symptoms partially to keep passability of nasal passes.

Multigrip Nazal contains a benzalkoniya chloride. This irritating substance which can cause undesirable reactions.

Multigrip Nazal spray contains sorbite. Patients with rare hereditary conditions of intolerance of fructose should not use this drug.

For reasons of hygiene and in order to avoid infections each bottle has to be used only by one person.

Use during pregnancy and feeding by a breast. Drug cannot be used during pregnancy because of potential vasoconstrictive effect. Proofs of any undesirable influence on babies are absent. However it is unknown whether xylomethazolinum gets into breast milk therefore it is necessary to be careful, and Multigrip Nazal during feeding by a breast it is necessary to apply only on doctor's orders.

Fertility. Appropriate data on influence of the medicine Multigrip Nazal on fertility are absent. As system exposure of xylomethazolinum of a hydrochloride very low, the probability of influence on fertility is extremely small.

Children. Multigrip Nazal, drops and spray nasal, solution of 0.05%. For treatment of children at the age of 2–12 years. It is contraindicated to children under 2 years.

Multigrip Nazal, drops and spray nasal, solution of 0.1%. For treatment of children aged from 12 years. It is contraindicated to children up to 12 years.

Ability to influence speed of response at control of vehicles or other mechanisms. Long-term treatment or use of xylomethazolinum in high doses increases risk of development of side reactions from central nervous system and a cardiovascular system. If there are such effects, then it can negatively affect ability to steer vehicles and to work with other mechanisms.

Interaction

Mao's Inhibitors. xylomethazolinum can strengthen effect of inhibitors of Mao and induce hypertensive crisis. xylomethazolinum is not recommended to patients who accept or accepted Mao's inhibitors during the last 2 weeks

Three - and tetracyclic antidepressants. At simultaneous application three - or tetracyclic antidepressants and sympathomimetics strengthening of sympathomimetic effect of xylomethazolinum is possible therefore simultaneous application of such means is not recommended.

Xylomethazolinum can influence effect of some antihypertensive drugs, such as blockers of β-adrenoceptors.

Overdose

inside can lead Excessive topical administration of xylomethazolinum of a hydrochloride or its accidental hit to developing of the expressed dizziness, the raised potoodeleniye, considerable decrease in body temperature, a headache, bradycardia, ag, respiratory depressions, a coma and spasms. after increase hell its decrease is possible. children of younger age are more sensitive to toxicity, than adults.

Treatment. All patients with suspicion on overdose should hold the relevant supporting activities and also, in case of need, urgent symptomatic treatment under control. Medical care has to include observation of the patient within several hours. In case of the heavy overdose which is followed by cardiac arrest, resuscitation actions have to continue not less than 1 h

Storage conditions

In original packing for protection against light at a temperature not above 25 °C.