Moksopres of the tab. of p/o of 0.2 mg No. 30

Moksopress – antihypertensive medicine for treatment of arterial hypertension.

Structure

• active ingredient: moksonidin;
• 1 tablet supports a moksonidin of 0.2 mg;
• other components: lactoses monohydrate, povidone, krospovidon, magnesium stearate;
• tablet cover: gipromelloza, polyethyleneglycol, titan dioxide (E171), ferrous oxide red (E172).

Moksonidin is contraindicated to

Contraindication

• hypersensitivity to active ingredient or to any component of medicine;
• sick sinus syndrome;
• bradycardia (the heart rate (HR) at rest is lower than 50 beats/min);
• to atrioventricular (AV) blockade ІІ and ІІІ degrees;
• heart failure.

Side reactions

Most frequent side effects at reception of a moksonidin include dryness in a mouth, dizziness, an asthenia and drowsiness. These symptoms often decrease after the first several weeks of treatment.

from mentality: often insomnia; infrequently – nervousness.

from nervous system: often headache, dizziness, vertigo, drowsiness; infrequently — obmorok*.

from organs of hearing and a labyrinth: seldom — a ring in ears.

from a cardiovascular system: seldom — bradycardia, hypotension * (including orthostatic hypotension).

from digestive tract: very often – dryness in a mouth; often – diarrhea, nausea, vomiting, dyspepsia.

Route of administration

Standard initial dose of a moksonidin makes 0.2 mg/days. The maximum single dose – 0.4 mg. The maximum daily dose – 0.6 mg – is applied for 2 receptions. The dose should be selected individually depending on reaction of the patient.

Moksonidin can be accepted irrespective of meal, washing down with a small amount of liquid.

Feature of use

Use during pregnancy or feeding by a breast

Pregnancy. Pregnant women do not have the relevant data on use of a moksonidin. Researches on animals showed embriotoksichesky effect. The potential risk for the person is unknown. Moksonidin it is not necessary to apply during pregnancy if there is no need.

Feeding by a breast.

Moksonidin gets into breast milk therefore it should not be applied during feeding by a breast. If therapy moksonidiny is considered necessary absolutely, feeding by a breast should be stopped.

Moksonidin is not recommended by

for use to children and teenagers (up to 18 years) because of insufficiency of data on safety and efficiency of medicament for this group of patients.

Ability to influence speed of response at control of motor transport or other mechanisms

Research of influence of a moksonidin on ability to run motor transport or to work with other mechanisms were not carried out by

.

Treatment of arterial hypertension this medicine demands regular medical observation. Various reactions about which it was reported in some cases (for example dizziness, drowsiness) can change reaction, worsening ability to run motor transport or to work with other mechanisms. It more belongs to the periods of an initiation of treatment, increase in a dose, change of medicament and interaction with alcohol.

Overdose

overdose Symptoms.

In some cases the overdose of a moksonidin, even in the dose of 19.6 mg taken for 1 time did not lead to a lethal outcome. Signs and symptoms of overdose include: a headache, sedation, drowsiness, arterial hypotension, dizziness, an asthenia, bradycardia, dryness in a mouth, vomiting, fatigue, pain in the upper site of a stomach. At heavy overdose the careful monitoring of emergence of disturbances of consciousness and respiratory depression is recommended.

After accidental reception by the two-year-old child of unknown quantity of a moksonidin (perhaps, 14 mg) observed sedation, a coma, arterial hypotension, a miosis and dispnoe. Gastric lavage, glucose infusion, controlled ventilation of the lungs and an immobilization led to total disappearance of symptoms within 11 hours.

Considering a research of use of high doses of medicament for animals, emergence of orthostatic dysregulation, temporary hypertensia, tachycardia and a hyperglycemia in addition is expected.

.

. In hypotension for maintenance of haemo circulation the use of a dopamine and administration of plazmozamenyayushchy solutions is recommended. At appearance of bradycardia it is possible to use atropine.

paradoxical hypertensive effects of overdose of a moksonidin.

Simultaneous use of a moksonidin with other antihypertensive medicaments results

in additive effect.

As tricyclic antidepressants can reduce efficiency of antihypertensive medicaments of the central action, co-administration of these medicaments with moksonidiny is not recommended.

Storage conditions

In original packing. Medicine does not demand special storage conditions.

out of children's reach.