Metformin is the medicine influencing digestive system and metabolism. Anti-diabetic drug.

Indications

Diabetes of the 2nd type at inefficiency of a dietotherapy and mode of physical activities, especially at patients with excess body weight:

• as monotherapy or as a part of combination therapy together with other oral hypoglycemic means or together with insulin for treatment of adults;
• as monotherapy or as a part of combination therapy with insulin for treatment of children for 10 years and teenagers.

For reduction of complications of diabetes at adult patients with diabetes of the 2nd type and excess body weight as medicament of the first line after an inefficient dietotherapy.

Structure

• 1 tablet contains a metformin hydrochloride in terms of 100% substance of 1000 mg;
• other components: sodium krakhmalglikolit (type A), povidone, starch corn, stearate of magnesium, silicon dioxide colloidal anhydrous; structure of a film cover: gipromeloza, polyethyleneglycol 6000, talc, titan dioxide (E171), propylene glycol.

Contraindication

• hypersensitivity to metformin or to any other component of medicine;
• any type of an acute metabolic acidosis (for example, lactoacidosis, diabetic ketoacidosis);
• diabetic prekoma;
• renal failure of heavy degree (glomerular filtration rate (GFR) <30 ml/min.).

Route of administration

Usually initial dose makes 500 or 850 mg (metformin, tablets, film coated, on 500 or 850 mg) 2–3 times a day in time or after meal.

In 10–15 days a dose should be modified according to results of measurements of level of glucose in blood serum.

Slow increase in a dose promotes decrease in side effects from a digestive tract.

Feature of use

to Patients needs to keep to a diet, uniform intake of carbohydrates within a day. Patients with excess body weight should continue to keep to a low-calorie diet. It is regularly necessary to control indicators of carbohydrate metabolism at patients.

Pregnant

In preclinical trials did not reveal negative impact on pregnancy, development of an embryo or a fruit, childbirth and postnatal development.

Children

to use the Drug Metformin to children of 10 years and to teenagers.

Drivers

metformin does not influence speed of response at control of motor transport or other mechanisms as medicament does not cause a hypoglycemia. However it is necessary to be careful at use of metformin in combination with other hypoglycemic means (sulphonylurea derivatives, insulin or meglitinida) because of risk of development of a hypoglycemia.

Overdose

At use of medicament in a dose of 85 g of development of a hypoglycemia it was not observed. However in this case development of lactoacidosis was observed. Considerable exceeding a dose of metformin or contributing factors of risk can cause lactoacidosis.

Side effects

Disbolism: lactoacidosis

from nervous system: disturbance of taste.

from a liver and biliary tract: disturbance of indicators of function of a liver or hepatitis completely disappearing after metformin cancellation.

from skin and hypodermic fabrics: the skin reactions including an erythema, an itching, a small tortoiseshell.

to Store

in original packing at a temperature not above 25 °C. To store out of children's reach.