tablets Metaminum are shown:

• In diabetes 2 types at inefficiency of a dietotherapy and mode of physical activities, especially at patients with excess body weight.
• as monotherapy or combination therapy together with other oral hypoglycemic means or together with insulin for treatment of adults.
• as monotherapy or combination therapy with insulin for treatment of children aged from 10 years and teenagers.
• For reduction of complications of diabetes at adult patients with diabetes 2 types and excess body weight as medicament of the first line at inefficiency of a dietotherapy.

Structure

Active ingredient: metformin hydrochloride (metformin hydrochloride);

1 tablet contains metformin of a hydrochloride 500 mg or 850 mg, or 1000 mg;

Excipients: lactose, povidone, magnesium stearate, silicon dioxide colloidal, hydroksipropilmetiltsellyuloza.

Contraindication

• hypersensitivity to metformin or to any other component of drug;
• any type of an acute metabolic acidosis (for example, lactoacidosis, diabetic ketoacidosis)
• diabetic coma;
• a renal failure of heavy degree (the glomerular filtration rate (GFR) <30 ml/min.)
• acute conditions proceeding with risk of developing renal failures such, as: organism dehydration, serious infectious diseases, shock;
• a disease which dekompensirovanny heart failure, respiratory insufficiency, recently postponed myocardial infarction, shock can lead to development of a hypoxia of fabrics (especially acute diseases or exacerbations of a chronic disease);
• liver failure, acute alcoholic poisoning, alcoholism.

Route of administration

Usually initial dose makes 500 mg or 850 mg 2-3 times a day in time or after meal.

In 10-15 days a dose needs to be modified according to results of measurements of level of glucose in blood serum.

Slow increase in a dose promotes decrease in side effects from a digestive tract.

.

Maximum recommended dose makes 3000 mg a day, divided into 3 receptions.

in case of transition from another of antidiabetic means needs to stop reception of this means and to appoint metformin as it is stated above.

Feature of use

Pregnant

in case of pregnancy planning and also in case of approach of pregnancy for treatment of diabetes recommends to apply metformin, and insulin to maintenance of level of glucose of blood as close as possible to normal, to reduction of risk of development of defects of a fruit.

Children

to use the Drug Metaminum for treatment of children aged from 10 years.

Drivers

With care

Overdose

At use of medicament in a dose of 85 g of development of a hypoglycemia it was not observed. However in this case development of lactoacidosis was observed. Considerable exceeding a dose of metformin or contributing factors of risk can lead to developing of a lactacidemia. Lactoacidosis is medical emergency. In case of development of a lactacidemia of medicament treatment it is necessary to stop and to urgently hospitalize the patient. The most effective action for removal from an organism of a lactate and metformin is the hemodialysis.

Side effects

from nervous system. Often: disturbance of taste.

from a digestive tract. Very often: disturbances from digestive system, such, as: nausea, vomiting, diarrhea, abdominal pain, lack of appetite. Most often these by-effects arise in an initiation of treatment and in most cases spontaneously disappear. For prevention of emergence of by-effects from digestive tract the slow increase in a dose of medicament is recommended.

Interaction

Alcohol. The acute drunkenness is associated with the increased risk of lactoacidosis, especially in cases of starvation or observance of a low-calorie diet and also in a liver failure. At medicament treatment Metaminum it is necessary to avoid the intake of ethanol and medicines containing ethanol.

Combination which should be applied with care. The medicines having hyper glycemic effect (GKS of systemic and local action, sympathomimetics). It is necessary to control to a thicket glucose level in blood, especially in an initiation of treatment. In time and after the termination of such combined therapy it is necessary to korrigirovat a dose Metaminum under control of level of a glycemia.

to Store

at a temperature not above 25ºС.

to Store

out of children's reach!

Expiration date - 3 years.