Powder for solution for injections Meronem is shown for treatment of infections at adults and children aged from 3 months:

• pneumonia, including community-acquired and hospital pneumonia,
• bronchopulmonary infections in a mucoviscidosis;
• complicated infections of urinary tract
• complicated intraabdominal infections;
• infections during childbirth and postnatal infections;
• complicated infections of skin and soft tissues;
• acute bacterial meningitis.

Structure

Active ingredient: meropenem;

: a meropenema trihydrate of 570 mg (500 mg of a meropenem anhydrous are equivalent) or a meropenema trihydrate of 1140 mg (1000 mg of a meropenem anhydrous are equivalent);

Excipients: sodium carbonate anhydrous.

Contraindication

• Hypersensitivity to active ingredient or excipient of drug.
• Hypersensitivity to any other antibacterial agent of group of karbapenem.
• Heavy hypersensitivity (for example, anaphylactic reactions, heavy skin reactions) to any other type a β-lactamnoma to antibacterial agent (for example penicillin or cephalosporins).

by

by dissolution of medicament in 0.9% chloride sodium solution for injections or in 5% solution of glucose (dextrose) for injections before obtaining concentration of 1-20 mg/ml.

Chemical and physical stability of the prepared solution for infusions with use of 0.9% of solution of sodium of chloride remained within 6 hours at the room temperature (15-25 °C) or within 24 hours at a temperature of 2-8 °C. The prepared solution if it was cooled, should be used within 2 hours after storage in the fridge. From the microbiological point of view medicament needs to be used immediately. If medicine was not used at once, term and a condition of its storage after preparation the doctor answers.

solution Prepared from 5% by solution of glucose (dextrose) should be used immediately, that is within 1 hour after preparation.

Pregnant

it is not recommended by

Feature of use

Children

use Drug to children aged from 3 months.

Drivers

.

Overdose

Relative overdoses perhaps at patients with a renal failure if the dose is not adjusted. The certain experience of post-marketing use of medicament demonstrates that if after overdose there are undesirable reactions, they will be coordinated with a profile below the specified side reactions, and as a rule, lungs on extent of manifestation and pass after medicament withdrawal or a dose decline. It is necessary to consider need of symptomatic treatment.

persons to normal function of kidneys have a fast removal of medicament kidneys.

meropeny and its metabolites out of an organism.

Side effects

• from the immune system: Quincke's disease, anaphylactic reactions.
• from blood: thrombocytopenia, eosinophilia, leukopenia, neutropenia, agranulocytosis, hemolytic anemia.
• from nervous system: headache, paresthesias, spasms.
• from a digestive tract: nausea, vomiting, diarrhea, abdominal pain; the colitis associated with use of antibiotics.
• from digestive system: increase in level of transaminases, increase in level of alkaline phosphatase, a lactate dehydrogenase and bilirubin in blood.
• from skin: rash, itching, urticaria, toxic epidermal necrolysis, Stephens-Johnson's syndrome, multiformny erythema.
• from an urinary system: increase in level of creatinine and urea in blood.
• General disturbances and reactions in the injection site: inflammation, pain, thrombophlebitis, pain in the place of an injection.

Interaction

At simultaneous use from karbapenema decrease in level of valproic acid in blood - for 60-100% approximately in 2 days. Through quick start of action and extent of decrease the simultaneous use of valproic acid and karbapenem is considered does not give in to adjustment therefore it is necessary to avoid such combination.

to Store

at a temperature not above 30 °C. Not to freeze.

to Store

out of children's reach.

Expiration date - 4 years.