tablets "Merkazolil-Zdorovye" are applied to treatment of a thyrotoxicosis:

• conservative treatment of a thyrotoxicosis, especially with absent or the small sizes a craw;
• preparation for surgical treatment at all forms of a thyrotoxicosis;
• preparation for treatment of a thyrotoxicosis radioiodine;
• therapy at stage of latency of effect of radioiodine;
• prevention of a thyrotoxicosis when prescribing medicaments of iodine at existence of a latent thyrotoxicosis, autonomous adenomas or a thyrotoxicosis in the anamnesis.

Structure

One tablet contains (active ingredient) of Thiamazolum of 5 mg.

Excipients: potato starch, calcium stearate, refined sugar, talc.

Contraindication

Hypersensitivity to medicament components / to other derivatives of tionamid, moderate and heavy disturbances of quantitative composition of blood (granulocytopenia), cholestasia before treatment, injuries of marrow at the therapy which is carried out earlier by Thiamazolum or carbimazole, compatible therapy by medicament and thyroid hormones during pregnancy is contraindicated, acute pancreatitis after use of Thiamazolum or carbimazole in the anamnesis.

Daily dose to apply

once or to divide into several receptions during the day. In an initiation of treatment the single doses should be accepted during the day, at regular intervals. To apply a maintenance dose for 1 reception, in time or after a breakfast.

to take the Pill without chewing, washing down with enough liquid. General recommendations about a dosage.

General recommendations about a dosage

Adult. Depending on severity of a disease and intake of iodine in an organism the recommended dose for adults makes 10-40 mg a day. In many cases the oppression of production of hormone of a thyroid gland is provided at reception of 20-30 mg a day. In a case of light severity to appoint medicament in lower dosage, at heavy degree of a disease it is necessary to use medicament in an initial dose of 40 mg a day.

individually, considering activity of the processes of metabolism caused by the level of production of hormone of a thyroid gland.

For performing maintenance therapy recommends such dosage:

• a maintenance dose - on 5-20 mg a day in a combination with left thyroxine, for prevention of a hypothyroidism;
• in the form of monotherapy - on 2.5-10 mg a day.

.

Children. To appoint medicament to children in an initial dose of 0.5 mg/kg of body weight a day.

After normalization of function of a thyroid gland to supporting which is defined with specific features of metabolism. In case of need in addition to appoint left thyroxine.

Pregnant

Woman of reproductive age effective methods of contraception have to apply

Feature of use during treatment.

Thiamazolum has to be appointed by

during pregnancy only after careful assessment of a ratio advantage/risk and in the most effective dose without additional prescribing of thyroid hormones. If Thiamazolum is applied during pregnancy, careful medical observation of mother, a fruit and the newborn is necessary. Thiamazolum gets through a placental barrier. In case of administration of medicament in incorrectly picked up doses there is a threat of growth of a thyroid gland and development of a hypothyroidism in a fruit and also decrease in body weight of a fruit.

Thiamazolum gets into breast milk where its concentration reaches concentration in blood serum of mother, than risk of development of a hypothyroidism at the child is caused. During feeding to appoint medicament a breast in the lowest effective doses which are not exceeding 10 mg a day without additional prescribing of hormones. It is regularly necessary to control function of a thyroid gland at newborns.

Children

by

to children aged from 3 years.

Drivers

Drug does not affect ability to run motor transport or other mechanisms.

Overdose can lead

to development of a hypothyroidism and owing to effect of a lack of hormones - activations of an adenohypophysis with the subsequent growth of a craw. In that case it is necessary to cancel medicament and if it is necessary, in addition to appoint use of thyroid hormones.

Side effects

from blood and lymphatic system: an agranulocytosis (it can be shown in weeks or months after an initiation of treatment, in most cases disappears independently after the termination of administration of drug), thrombocytopenia, a pancytopenia, a generalized lymphadenopathy.

from an endocrine system: an insulin autoimmune syndrome with sharp decrease in concentration of glucose in blood.

from nervous system: disturbance of flavoring feelings (dysgeusia, an ageusia), independently there pass after the termination of administration of medicament (sometimes flavoring feelings are restored in several weeks after the termination of a course of treatment) neuritis, polyneuropathy, fever.

from digestive system: acute inflammation of sialadens, acute pancreatitis.

from digestive system: cholestatic jaundice or toxic hepatitis. Symptoms, as a rule, disappear after the termination of administration of drug. Clinical hardly noticeable symptoms of stagnation of bile during treatment should be distinguished from the dysfunctions caused by a hyperthyroidism such as increase in level of a γ-glutamiltransferaza and alkaline phosphatase.

from skin: allergic skin reactions (itching, rash, urticaria), usually moderate severity which disappear at further therapy; severe forms of allergic reactions, including generalized dermatitis, alopecias, the lupus erythematosus induced by medicine.

from a musculoskeletal system: an arthralgia that develops gradually and can arise even in several months of therapy.

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 5 years.