Tablets of Medoklav are applied to treatment of the bacterial infections caused by microorganisms, sensitive to drug:

• sharp bacterial sinusitis;
• sharp average otitis;
• confirmed exacerbation of chronic bronchitis;
• community-acquired pneumonia;
• cystitis;
• pyelonephritises;
• an infection of leather and soft tissues, including cellulitis, stings of animals, heavy dentoalveolyarny abscesses with widespread cellulitis;
• an infection of bones and joints, including osteomyelitis.

Structure

Active ingredients: 1 tablet, coated, contains amoxicillin trihydrate of 1004 mg is equivalent amoxicillin of 875 mg of potassium clavulanate of 148.9 mg is equivalent clavulanic acid of 125 mg;

Excipients: microcrystalline cellulose, starch sodium (type A), silicon dioxide colloidal, magnesium stearate, a film cover supports a hydroksipropilmetiltsellyuloz, propylene glycol, polyethyleneglycol 6000, talc, the titan dioxide (E 171).

Contraindication

• hypersensitivity to medicine components, to any antibacterial agents of group of penicillin;
• existence in the anamnesis of the heavy reactions of hypersensitivity (including an anaphylaxis) connected with application of others beta laktamnykh agents (including cephalosporins, karbapenem or monobaktam);
• existence in the anamnesis of jaundice or the dysfunction of a liver connected with use of amoxicillin/clavulanate.

Route of administration

Praparat should be applied according to the official recommendations about antibiotic treatment and data of local sensitivity to an antibiotic. The sensitivity to amoxicillin / clavulanate differs in different regions and can change over time. In case of need it is necessary to address data on local sensitivity and if necessary to carry out microbiological definition and the sensitivity test.

As a tablet cannot be shared, to children with body weight less than 25 kg, given not to appoint a dosage form.

Feature of application

Pregnant

As well as concerning other medicines, it is necessary to avoid use of medicine during pregnancy, especially in the I trimester, except cases when the advantage of use of medicine exceeds potential risk.

Children

to Apply to children aged from 6 years with body weight not less than 25 kg.

Drivers

Researches on studying ability of medicine to influence speed of response at control of motor transport or other mechanisms. However, there can be side reactions (for example allergic reactions, dizziness, spasms) which can affect ability to drive the car or other mechanisms.

Overdose

Overdose can be followed by symptoms from digestive tract and violation of water and electrolytic balance. These phenomena treat symptomatic, paying attention to correction of water and electrolytic balance. It was reported about crystalluria cases which can sometimes cause a renal failure. Medoklav it is possible to remove from blood by a hemodialysis.

Side effects

Infection and invasion: candidiasis of skin and mucous membranes, excessive increase in insensitive microorganisms, aseptic meningitis.

from blood and lymphatic systems: a reversible leukopenia (including a neutropenia), thrombocytopenia, a reversible Agranulocytosis, hemolytic anemia, increase in a bleeding time and the prothrombin ratio.

from the immune system: Quincke's disease, anaphylaxis, syvorotochnopodobny syndrome, allergic vasculitis.

from nervous system: dizziness, headache, reverse hyperactivity and spasms.

from a digestive tract: diarrhea, nausea, vomiting, digestion violation, antibiotikoassotsiirovanny colitis (including pseudomembranous and hemorrhagic colitis), black hairy language.

from a gepatobiliarny system: moderate increase in level of nuclear heating plant and/or ALT was noted at patients who were treated by antibiotics of group of beta lactams, however the clinical value of it is not established; hepatitis, cholestatic jaundice. These phenomena arose at use of other penicillin and cephalosporins.

from skin and hypodermic fabric: skin rashes, itch, small tortoiseshell, polymorphic erythema, Stephens-Johnson's syndrome, toxic epidermal necrolysis, bullous exfoliative dermatitis, sharp generalized exanthematous pustulez.

from kidneys and an urinary system: interstitial nephrite, crystalluria.

by

. Probenetsid reduces renal canalicular secretion of amoxicillin. Simultaneous application of a probenetsid can lead to increase in level and duration of effect of amoxicillin (but not clavulanic acid) in blood.

Storage conditions

to Store

in original packing at a temperature not above 25 °C, out of children's reach.

Expiration date - 2 years.