tablets Maksigra are shown for treatment of disturbances of an erection which are defined as inability to reach and support the penis erection necessary for successful sexual intercourse.

For effective effect of the medicament Maksigra needs sexual excitement.

Structure

Active ingredient: sildenafit;

1 tablet supports a sildenafil citrate that is equivalent a sildenafila of 50 mg or 100 mg;

Excipients: mannitol (E 421), krospovidon (type A), K-30 povidone, starch corn, sodium lauryl sulfate, magnesium stearate, silicon dioxide colloidal;

Cover: gipromelloza, magrogol 6000, titan dioxide (E 171), talc, indigotin (E 132).

Contraindication

• Hypersensitivity to active agent or any of medicament excipients.
Simultaneous use with donors of nitrogen oxide (such as amyle nitrite) or nitrates in any form is contraindicated to
• as it is known that sildenafit influences ways of metabolism of oxide of nitrogen / the cyclic guanozinmonofosfat (tsGMF) and exponentiates hypotensive effect of nitrates.
• Simultaneous use of FDE-5 inhibitors (including sildenafit) with guanylate cyclase stimulators, such as riotsiguat, it is contraindicated as can lead to symptomatic hypotension.
• State at which the sexual activity is not recommended (for example heavy cardiovascular disorders, such as unstable stenocardia or heart failure of heavy degree).
• Loss of sight on one eye owing to a nearterialnoa of a front ischemic neuropathy of an optic nerve irrespective of, this pathology is connected with the previous use of FDE-5 inhibitors or not.
• Presence of such diseases: an abnormal liver function of heavy degree, arterial hypotension (arterial blood pressure is lower than 90/50 mm Hg.).
• Recently had stroke or a myocardial infarction and the known hereditary degenerative diseases of a retina, such as pigmentary retinitis (a small amount of such patients has genetic disorders of FDE of a retina) as safety of a sildenafil were not investigated in case of such diseases.

Route of administration

Drug is used orally. Before swallowing a tablet to chew.

For effective effect of medicament needs sexual excitement.

Adult. The recommended dose makes 50 mg and is applied, in case of need, approximately for an hour before sexual intercourse. Depending on efficiency and tolerance of medicament it is possible to increase a dose to 100 mg or to lower to 25 mg. The maximum recommended dose makes 100 mg.

Maximum recommended frequency of use of medicament is 1 time a day. At use of medicament during meal the effect of medicament can come later, than at its use on an empty stomach.

Feature of use

Pregnant

it is not intended for use to women.

by

to use by persons aged up to 18 years.

Drivers

With care.

Overdose

In researches with participation of volunteers at use of a single dose of a sildenafil up to 800 mg the side reactions were similar to those which were observed at use of a sildenafil in lower doses, but met more often and were heavier. Use of a sildenafil in a dose of 200 mg did not lead to increase in efficiency, but caused growth of quantity of cases of development of side reactions (a headache, rushes of blood, dizziness, dyspepsias, congestions of a nose, disturbances from organs of sight).

in case of overdose if necessary resort to usual the supporting actions. Acceleration of clearance of a sildenafil at a hemodialysis is improbable owing to high extent of linking of medicament with proteins of blood plasma and lack of elimination sildenafit with urine.

Side effects

it was Most often reported about such side reactions as a headache, rushes of blood, dyspepsia, congestion of a nose, a dorsodynia, dizziness, nausea, inflows of heat, a disorder of vision, blue vision and turbidity of sight.

Interaction

Metabolism of a sildenafil happens mainly to participation of ZA4 isoform (main way) and isoforms 2C9 (minor way) of P450 cytochrome (CYP). Therefore inhibitors of these isoenzymes can reduce clearance of a sildenafil, and inductors of these isoenzymes can increase clearance of a sildenafil.

Storage conditions

Drug does not demand special storage conditions.

out of children's reach.

Expiration date - 4 years.