Makrotsef time. baby solution for infection. 1000mg/1000mg fl. No. 5

Powder for preparation of solution for injections Makrotsef is appointed for treatment of the infections caused by microorganisms, sensitive to drug:

• respiratory infection (upper and lower parts);
• an infection of urinary tract (upper and lower parts);
• peritonitis, cholecystitis, cholangitis and other infections of an abdominal cavity;
• septicaemia,
• meningitis
• an infection of leather and soft tissues;
• an infection of bones and joints;
• inflammatory diseases of bodies of a small pelvis, endometritis, gonorrhea and other infections of genitals.

Structure

Active ingredients: cefoperazone, sulbactam;

1 bottle supports a tsefoperazon of sodium is equivalent a tsefoperazona of 500 mg of a sulbaktam of sodium is equivalent a sulbaktama of 500 mg;

1 bottle supports a tsefoperazon of sodium is equivalent a tsefoperazona of 1000 mg, a sulbaktama of sodium is equivalent a sulbaktama of 1000 mg.

Contraindication

It is contraindicated to patients with an allergy to penicillin, to sulbakta, tsefoperazon or any cephalosporin.

Route of administration and doses

Before use of medicine needs to take skin samples on shipping.

Use for adults. The standard dose for adults makes from

2 up to 4 g in day (that is from 1 to 2 g of a tsefoperazon in day), intravenously or intramusculary, in is equivalent the divided doses each 12 hours.

In heavy or refractory infections to 8 g (that is a dose of a tsefoperazon - 4 g), enter in evenly distributed doses each 12 hours. The recommended maximum daily dose of a sulbaktam makes 4 g (8 g of medicine).

Feature of application

Pregnant

only when the advantage for mother exceeds potential risk for a fruit.

Children

children can use Drug.

Influence is improbable

.

Overdose

Information on acute toxicity of a tsefoperazon of sodium and sulbaktam of sodium at people. The overdose of medicine can cause the manifestations representing the enhanced side effects. It is necessary to take into account that high concentrations beta laktamnykh antibiotics in cerebrospinal fluid can cause neurologic reactions, in particular spasms. As tsefoperazon and to sulbakta are allocated from the system of circulation by a hemodialysis, this procedure can strengthen elimination of medicine from an organism in case of overdose at patients with a renal failure.

Sulbaktam/tsefoperazon in general is well had by

. The majority of side reactions of light or moderate severity also have a favorable course at long-term treatment.

Interaction

Aminoglycosides. Mixing of medicine with aminoglycosides in one syringe leads to a mutual inactivation; if these groups of antibacterial agents need to be applied at the same time, then it is necessary to enter them into different places at an interval of 1 hour. Increases risk of development of nephrotoxicity of aminoglycosides, furosemide.

Bacteriostatic medicines (chloramphenicol, erythromycin, streptocides, tetracycline) reduce activity of medicine.

Probenetsid reduces canalicular secretion of a sulbaktam; increase in their concentration in plasma of blood and elimination half-life of medicines and increases in risk of intoxication is result of it. Enhances risk of bleeding at application with non-steroidal anti-inflammatory drugs.

Alcohol. At alcohol intake during a course of treatment and within 5 days after treatment tsefoperazony such reactions as face reddening, perspiration, a headache, tachycardia were noted. Similar reactions were observed also at use of other cephalosporins. Patients should be careful at consumption of alcoholic beverages at use of medicine. At application of artificial nutrition (oral or parentalny) the solutions containing ethanol should not be used.

to Store

in original packing at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date - 2 years.