MAGNE-V6 – magnesium medicine for treatment of deficiency of magnesium in an organism.

Magnesium – the intracellular cation reducing excitability of neurons and suppressing neuromuscular transmission. Participates in many enzymatic reactions. Is an important component of a skeleton: bones of the person contain a half of all amount of the magnesium which is present at a body. The magnesium which is contained in medicament Magne-B6 is intended for correction of insufficiency of magnesium in an organism.

Indications

Treatment of the confirmed deficiency of magnesium in an organism both isolated, and associated with other scarce states.

Structure

• active ingredients: magnesium, pyridoxine;
1 tablet contains
• magnesium of a lactate of a dihydrate of 470 mg (that corresponds to 48 mg of Mg2 + or 1.97 mmol) and a pyridoxine of a hydrochloride (B6 vitamin) of 5 mg;
• other components: sucrose, kaolin, acacia, carbomer, talc, magnesium stearate;
• cover: acacia, sucrose, titan dioxide (E 171), talc, karnaubsky wax.

Contraindication

Hypersensitivity to medicine components. A heavy renal failure with an indicator of clearance of creatinine less than 30 ml/min. Phenylketonuria. Gipermagniyemiya, B6 vitamin hypervitaminosis, myasthenia gravis. Atrioventricular block, heavy arterial hypotension. Simultaneous application with a levodopa. Diarrhea. Intolerance of fructose, a sprue of glucose or a galactose, deficiency of invertase-isomaltase (because of the content in sucrose drug).

Side reactions

from the immune system - frequency is unknown: allergic reactions, hypersensitivity, Quincke's disease.

from digestive tract - frequency is unknown: diarrhea, nausea, vomiting, abdominal pain.

from skin and hypodermic fabrics - frequency is unknown: skin reactions, including urticaria, itch, eczema, erythema.

Route of administration

Tablet should be swallowed entirely, washing down with 1 glass of water.

Adult: 6–8 tablets a day with distribution of the general dose to 2 or 3 inclusion in meal time.

to Children of 6 years (with body weight more than 20 kg): 10–30 mg/kg of body weight a day (i.e. 0.4-1.2 mmol/kg of body weight a day) that corresponds to reception of 4-6 tablets for day day with distribution of the general dose to 2 or 3 inclusion in meal time.

Use of medicine should be stopped as soon as magnesium level in blood reaches normal.

Feature of application

to Patients with heavy deficiency of magnesium should begin use of medicine with its introduction with an intravenous way. It is also shown to patients with malabsorption.

Use during pregnancy or feeding by a breast

Pregnancy. Limited data of clinical trials on animals did not reveal fetotoksichesky or embriotoksichesky effect of medicine. Thus, use of magnesium during pregnancy is possible only in need of and after consultation with the doctor.

feeding Period breast. Each of active ingredients of medicine separately (both magnesium, and B6 vitamin) is not contraindicated during this period. Considering limited evidential data on application of the maximum recommended daily dose of B6 vitamin during feeding by a breast, it is recommended to appoint no more than 20 mg/days of B6 vitamin.

Children

use Drug to children of 6 years. The corresponding dosage forms are available to children to application up to 6 years.

Ability to influence speed of response at control of motor transport or other mechanisms

Magne-B6 Medicine, tablets, coated, does not influence or slightly influences speed of response at control of motor transport or other mechanisms.

Connected with magnesium

Overdose of magnesium at its oral administration usually does not lead

to development of toxic reactions in patients with normal kidney function. However at patients with a renal failure intoxication magnesium can develop.

Toxic effects depend on magnesium levels in blood and are shown by the following signs:

• sharp decrease in the ABP;
• nausea, vomiting;
• oppression of the central nervous system, violation of reflex functions;
• pathological changes of the ECG;
• development of respiratory depression, comma, cardiac arrest and paralysis of breath;
• anury.

overdose Treatment: rehydration, the diuresis forced. The hemodialysis or peritoneal dialysis is necessary for patients with a renal failure.

to

Interaction with other medicines and other types of interactions

Are contraindicated to a combination.

Should avoid simultaneous application with a levodopa as at the same time action of a levodopa is inhibited when its application is not followed by intake of inhibitors of a peripheral dopadekarboksilaza. Use of a pyridoxine in any quantities is not shown if reception of a levodopa is not followed by intake of inhibitors of a dopadekarboksilaza.

Unrecommended compositions.

with the medicines containing phosphatic or calcic salts as they oppress absorption of magnesium from intestines.

to Store

at a temperature above 30 °C. To store out of children's reach.