Pharmacological properties

Pharmacodynamics

Levofloxacin — synthetic antibacterial medicine of group of ftorkhinolon, is s-enantiomerom of racemic mix of medicine of an ofloksatsin.

action Mechanism. As antibacterial medicine of group of ftorkhinolon levofloxacin affects the DNK-girazy complex and topoisomerase IV.

Pharmacodynamics

Degree of bacterial activity of a levofloksatsin depends on a ratio With _max or AUC and the minimum inhibiting concentration (MIC).

resistance Mechanism. The main mechanism of resistance is a consequence of a mutation in gyr-A genes. In vitro exists cross resistance between levofloksatsiny and other ftorkhinolona.

Thanks to the action mechanism usually the cross resistance between levofloksatsiny and other classes of antibacterial means does not exist.

Extreme values. The MIK limit values recommended by the European committee on testing of antimicrobic sensitivity (EUCAST) for a levofloksatsin separating sensitive microorganisms from organisms it is intermediate sensitive (moderately resistant) and is intermediate sensitive from resistant organisms, are given below in the table of testing of MIK (mg/l).

MIK EUCAST Clinical limit values for a levofloksatsin (20.06.2006):

¹ MIK Limit value between sensitive is also intermediate ≤1 sensitive (moderately resistant) strains was increased from 1 to 2 for the purpose of control of growth of wild strains of this microorganism, show variability of this parameter. Extreme values concern therapy of high doses.

² Strains with sizes MIK above extreme value between sensitive it is also intermediate sensitive (moderately resistant) strains very rare or about them it was not reported yet. Tests for identification and antimicrobial sensitivity on any similar isolate should be repeated and if the result is confirmed, to direct isolate to exploratory laboratory.

³ , proceeding from data of a pharmacokinetics/pharmacodynamics and are independent of distribution of MIK of certain types. It