tablets Lisinopril are applied at the following indications:

• Arterial hypertension.
• Chronic heart failure.
• Acute myocardial infarction at patients with stable indicators of a hemodynamics (systolic arterial blood pressure> 100 mm Hg.).
• Diabetic nephropathy in diabetes (at patients with insulin-dependent diabetes ІІ type).

Structure

Active ingredient: lisinopril;

1 tablet contains lisinopril 10 mg;

Excipients: calcium hydrophosphate, attracts (E 421), starch corn, magnesium stearate, silicon dioxide colloidal anhydrous.

Contraindication

• Hypersensitivity to lisinopril, to other components of medicament or to other APF inhibitors.
• Quincke's disease in the anamnesis (including after use of APF inhibitors, idiopathic and hereditary hypostasis).
• Aortal or mitral stenosis or a hypertrophic cardiomyopathy with the significant hemodynamic disturbances.
• Bilateral renal artery stenosis or stenosis of an artery of the only kidney; an acute myocardial infarction with an unstable hemodynamics; cardiogenic shock; simultaneous use of medicament and high-throughput membranes with poliakrilnitrilnatriya-2-metilalilsulfonata (for example, AN 96) at urgent dialysis; patients with creatinine level in blood serum ≥ 220 µmol/l.
• Simultaneous use of aliskirensoderzhashchy medicaments to patients with diabetes or disturbances of functions of kidneys (SKF <60 ml/min. / 1.73 sq.m).
• Primary hyper aldosteronism.

Route of administration

Pill is taken in 1 times a day, time, irrespective of meal is desirable in one and too. The daily dose is selected individually depending on reaction of the patient and indicators of arterial blood pressure.

Feature of use

Pregnant

It is contraindicated.

Safety and efficiency of use of lisinopril are not established to children by

therefore it is not necessary to appoint the medicament Lizinopril-Astrafarm of this age category of patients.

Drivers

needs to take possibility of dizziness and increased fatigue into account that can affect ability to run motor transport or other mechanisms.

Overdose

Symptoms: arterial hypotension, circulator shock, electrolytic disturbances, renal failure, hyperventilation, tachycardia, heart consciousness, bradycardia, dizziness, concern and cough.

Treatment: intravenous administration of saline solutions. In arterial hypotension it is necessary to put the patient on a back with raised upside down. If it is possible, appoint infusion of angiotensin II and/or intravenously enter catecholamines. If the medicament is taken recently, washing is shown to a stomach, use of absorbents and sodium of sulfate. For treatment of steady bradycardia the use of a pacemaker is shown.

recommends constant control of laboratory indicators (determination of level of electrolytes and creatinine in blood serum) and vital signs.

from an organism by means of a hemodialysis, at the same time it is necessary to avoid use of polyacrylonitrile metallosulfonatny high-flowing membranes (for example AN69).

in case of a Quincke's disease are appointed by antihistaminic drugs. If the clinical situation is followed by hypostasis of language, a glottis, throat, it is necessary to begin in an urgentny order treatment by transdermalny introduction of 0.3-0.5 ml of solution of adrenaline (1:1000), for ensuring passability of airways the intubation or laryngotomy are shown.

Side effects

• from the system of blood: decrease in level of hemoglobin and hematocrit, oppression of activity of marrow, anemia, thrombocytopenia, leukopenia, neutropenia, agranulocytosis, hemolytic anemia, lymphadenopathy, autoimmune disease.
• from a metabolism: hypoglycemia.
• from the central nervous system: dizziness, headache, change of mood, paresthesia, disturbance of flavoring feelings, sleep disorder, balance disturbance, disorientation, confusion of consciousness, disturbance of a scent, depression symptoms, faint.
• from a cardiovascular system: orthostatic effect (including arterial hypotension), a myocardial infarction or a cerebrovascular stroke, perhaps, secondary because of excessive arterial hypotension at patients of group of high risk, palpitation, tachycardia, Reynaud's phenomenon.
• from a musculoskeletal system: muscular spasms were registered.
• from a respiratory system: cough, bronchitis, rhinitis, short wind, dispnoe, Quincke's disease, bronchospasm, glossitis, sinusitis, allergic alveolitis / eosinophilic pneumonia. Upper respiratory tract infections were registered.
• from a digestive tract: diarrhea, vomiting, nausea, an abdominal pain, dyspepsia, dryness in a mouth, reduction of appetite, change of taste, pancreatitis, an intestinal Quincke's disease, a constipation, hepatitis (hepatocellular or cholestatic), jaundice and a liver failure.
• from skin: rash, sverbezh, hypersensitivity / a Quincke's disease of the face, extremities, lips, language, a glottis and/or throat, feeling of heat, a dermahemia, urticaria, an alopecia, psoriasis, the raised potovydeleniye, a pempigus, a toxic epidermal necrolysis, Stephens-Johnson's syndrome, a polymorphic erythema, a skin lymphocytoma.
to
• It was reported about a syndrome, including one or several symptoms: fever, vasculitis, myalgia, arthralgia/arthritis, emergence of positive antinuclear antibodies, acceleration of blood sedimentation rate, eosinophilia and leukocytosis, rashes, photosensitization or other skin manifestations.
• from an urinary system: renal dysfunction, uraemia, acute renal failure, oliguria/anury.
• from an endocrine system: inadequate secretion of antidiuretic hormone.
• from a reproductive system: impotence, gynecomastia.
• General disturbances: increased fatigue, weakness.

Interaction

Contraindicated simultaneous use of medicament and high-throughput membranes with poliakrilnitrilnatriyu-2-metilosulfonatu (for example AN 69) at urgent dialysis.

APF Inhibitors exponentiate effect of ethanol. Ethanol increases arterial blood pressure, reducing effect of APF inhibitors.

to Store

at a temperature not above 25 °C.

to Store

out of children's reach.

Expiration date - 3 years.