Lipid-lowering drug from the statin group. HMG-CoA reductase inhibitor.

If you have been diagnosed with hypercholesterolemia, you cannot ignore the advice of your doctor. You have been prescribed a drug, and you are thinking how to buy Lipitor for a patient with hypercholesterolemia. Contact us, we will help you with the order of the drug and give you detailed advice if you have any questions.

Mechanism of action

Lipitor reduces the level of cholesterol and lipoproteins in the blood plasma while inhibiting the activity of HMG-CoA reductase, cholesterol synthesis in the liver and an increase in the number of hepatic LDL receptors on the cell surface, which leads to increased delight and catabolism of LDL.

The drug leads to a reduced formation of LDL, to a pronounced and sustained increase in the activity of LDL receptors. Reduces the level of LDL in patients with homozygous familial hypercholesterolemia, resistant to treatment with other lipid-lowering drugs.

Application protocol

The drug is taken orally, regardless of food intake. The initial dose of Lipitor is 10 mg once a day. The maximum daily dose is 80 mg once a day.

Efficiency

According to the results of clinical studies, Lipitor significantly reduces the risk of ischemic complications (including death from myocardial infarction), the risk of re-hospitalization through angina pectoris, accompanied by signs of myocardial ischemia

Indications

heterozygous familial and non-familial (primary) hypercholesterolemia, by Frederickson type IIa), combined hyperlipidemia (by Frederickson type IIb and III), dysbetalipoproteinemia (by Frederickson type III) (in addition to diet), familial endogenous hypertriglyceridemia (by type IV), which not amenable to correction with diet.

homozygous hereditary hypercholesterolemia (in addition to hypolipidemic therapy, including autohemotransfusion of blood purified from LDL).

cardiovascular diseases against the background of dyslipidemia

secondary prevention to reduce the overall risk of death, myocardial infarction and re-hospitalization for angina pectoris.

Contraindications

hypersensitivity to Lipitor components

chronic alcoholic hepatitis, active chronic hepatitis, hepatic failure, increased activity of hepatic transaminases of unspecified origin

pregnancy and the period of breastfeeding.

Side effects

dizziness, insomnia, headache, asthenia, malaise, drowsiness

amnesia, paresthesia, peripheral neuropathy, amnesia, emotional lability, depression, ataxia, facial paralysis, hyperkinesis, hyperesthesia, loss of consciousness

dryness of the conjunctiva, hemorrhage in the eyes, amblyopia, ringing in the ears, impaired accommodation, deafness, glaucoma, loss of taste, taste perversion, parosmia

nausea heartburn, diarrhea, constipation, flatulence, gastralgia, abdominal pain, decreased or increased appetite, anorexia, dry mouth, dysphagia, belching, vomiting, gastroenteritis, esophagitis, glossitis, stomatitis, erosive and ulcerative lesions of the oral mucosa

hepatitis, biliary colic, cheilitis, duodenal ulcer, liver dysfunction, pancreatitis, cholestatic jaundice, rectal bleeding, melena, tenesmus

shortness of breath, bronchitis, rhinitis, pneumonia, bronchial asthma, nosebleeds

chest pain; vasodilation, palpitations, migraine, postural hypotension, increased blood pressure, arrhythmia, angina

anemia, phlebitis, lymphadenopathy, thrombocytopenia

arthritis leg muscle cramps, bursitis, tendosynovitis, myopathy, myositis, arthralgia, myalgia, rhabdomyolysis, muscle hypertonicity, joint contractures, torticollis

urogenital infections, peripheral edema; dysuria (nocturia, pollakiuria, urinary retention or incontinence, urge to urinate, hematuria, nephrourolithiasis, nephritis, epididymitis, metrorrhagia, vaginal bleeding, decreased libido, impotence, impaired ejaculation

xeroderma, seborrhea, eczema, alopecia, increased sweating, petechiae, ecchymosis

skin rash, pruritus, contact dermatitis, urticaria, angioedema, facial edema, photosensitivity, anaphylaxis, toxic epidermal necrolysis, exudative erythema multiforme (Stevens-Johnson syndrome)

hyperglycemia, hypoglycemia, increased serum CPK levels, albuminuria

weight gain, exacerbation of gout, gynecomastia, mastodynia.

Interaction

The simultaneous use of cyclosporine, erythromycin, fibrates, clarithromycin, immunosuppressive, antifungal drugs of the azole group and nicotinamide leads to an increase in the concentration of Lipitor in the blood plasma.

Concomitant administration of Lipitor with inhibitors of cytochrome CYP3A4 increases plasma concentration.

Lipitor can increase the concentration of digoxin and oral contraceptives containing norethindrone and ethinyl estradiol.

Storage conditions

Store at a temperature not exceeding 25 ° C in a dark place. Keep out of the reach of children.